କାଲସିଟ୍ରିଓଲ

କାଲସିଟ୍ରିଓଲ
Clinical data
Pronunciation	US: /ˌkælsɪˈtraɪɒl/; ; UK: /kælˈsɪtriɒl/
Trade names	Rocaltrol, Calcijex, Decostriol, others
Synonyms	1,25-dihydroxycholecalciferol, 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D3, 1α,25-(OH)2D3, 1,25(OH)2D
AHFS/Drugs.com	monograph
MedlinePlus	a682335
data	US DailyMed: Calcitriol;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, IV
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	99.9%
Metabolism	Kidney
Elimination half-life	5–8 hours (adults), 27 hours (children)
Excretion	Faeces (50%), urine (16%)
Identifiers
	IUPAC name (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol;
ECHA InfoCard	100.046.315
Chemical and physical data
Formula	C27H44O3
Molar mass	୪୧୬.୬୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C;
	InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 ; Key:GMRQFYUYWCNGIN-NKMMMXOESA-N ;
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କାଲସିଟ୍ରିଓଲ ହେଉଛି ଭିଟାମିନ ଡି ବା 'ଜୀବସାର ଘ'ର ଏକ ସକ୍ରିୟ ରୂପ ଯାହା ସାଧାରଣତଃ ବୃକ୍‌କରେ ତିଆରି ହୁଏ | ^[୮] କମ୍ ରକ୍ତ କ୍ୟାଲସିୟମ୍ ହେଉଥିବା ବୃକ୍‌କ ରୋଗ, ହାଇପରପାରାଥାରଏଡିଜ୍ମ; ହାଇପୋପାରାଥାଇରଏଡିଜମ, ଓଷ୍ଟିଓପୋରୋସିସ୍, ଓଷ୍ଟିଓମାଲାସିଆ ଓ ଫାମିଲିଆଲ ହାଇପୋଫସଫାଟେମିଆ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ଏହି ଉତ୍ପାଦିତ ଆକାରର ଔଷଧ ବ୍ୟବହୃତ ହୁଏ | ^[୯] ^[୧୦] ଏହା ପାଟିରେ କିମ୍ବା ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ | ^[୧]

ଅତ୍ୟଧିକ ପରିମାଣରେ ଦେଲେ ସାଧାରଣତଃ ଦୁର୍ବଳତା, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, କୋଷ୍ଠକାଠିନ୍ୟ, ମୂତ୍ରାଙ୍ଗ ସଂକ୍ରମଣ ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୁଏ | ^[୯] ^[୧୦] ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତ କ୍ୟାଲସିୟମ୍ ଏବଂ ଆନାଫାଇଲକ୍ସିସ୍ ହୋଇପାରେ | ^[୧] ଔଷଧ ଦେବା ଆରମ୍ଭ ହେବା ପରେ ଏବଂ ଏହାର ମାତ୍ରା ପରିବର୍ତ୍ତନ ହେବା ପରେ ନିୟମିତ ରକ୍ତ ପରୀକ୍ଷା କରିବାକୁ ପରାମର୍ଶ ଦିଆଯାଏ | ^[୧୧] କ୍ୟାଲସିଟ୍ରିଓଲ ମୁଖ୍ୟତଃ ଅନ୍ତନଳୀରୁ କ୍ୟାଲସିୟମ ଗ୍ରହଣ ମାତ୍ରା ବୃଦ୍ଧି କରି ରକ୍ତ କ୍ୟାଲସିୟନ (Ca ²⁺ ) ମାତ୍ରା ବୃଦ୍ଧି କରିଥାଏ | ^[୧]

୧୯୭୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ଚିକିତ୍ସା ନିମନ୍ତେ କାଲସିଟ୍ରିଓଲ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୯] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ ସୁଦ୍ଧା ଏନଏଚଏସ ମୂଲ୍ୟ ୯.୭୦ପାଉଣ୍ଡ ଥିଲା । ^[୧୦] ^[୧୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୨୭ ଡଲାର ଥିଲା । ^[୧୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୭ରେ ମସିହାରେ ଏହା ୨୫୬ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଏକ ମିଲିୟନରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୩] ^[୧୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Calcitriol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 9 April 2019.
↑ "IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D. Recommendations 1981". European Journal of Biochemistry. 124 (2): 223–7. May 1982. doi:10.1111/j.1432-1033.1982.tb06581.x. PMID 7094913.
↑ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier, archived from the original on 2014-01-11, retrieved 2022-02-10.
↑ Wolters Kluwer, Stedman's Medical Dictionary, Wolters Kluwer.
↑ Merriam-Webster, Merriam-Webster's Medical Dictionary, Merriam-Webster.
↑ Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt, archived from the original on 2015-09-25, retrieved 2015-09-25.
↑ Merriam-Webster, Merriam-Webster's Unabridged Dictionary, Merriam-Webster, archived from the original on 2020-05-25, retrieved 2022-02-10.
↑ Encyclopedia of Endocrine Diseases (in ଇଂରାଜୀ). Academic Press. 2018. p. 344. ISBN 9780128122006.
↑ ^୯.୦ ^୯.୧ ^୯.୨ "Calcitriol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 9 April 2019.
↑ ^୧୦.୦ ^୧୦.୧ ^୧୦.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.
↑ ^୧୧.୦ ^୧୧.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.
↑ "CY 2016 Outlier Services" (PDF). Retrieved 13 April 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Calcitriol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[AHFS2019-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Calcitriol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 9 April 2019.

[Nomen1981-2] "IUPAC-IUB Joint Commission on Biochemical Nomenclature (JCBN): Nomenclature of vitamin D. Recommendations 1981". European Journal of Biochemistry. 124 (2): 223–7. May 1982. doi:10.1111/j.1432-1033.1982.tb06581.x. PMID 7094913.

[Dorlands-3] Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier, archived from the original on 2014-01-11, retrieved 2022-02-10.

[Stedmans-4] Wolters Kluwer, Stedman's Medical Dictionary, Wolters Kluwer.

[MW_Medical-5] Merriam-Webster, Merriam-Webster's Medical Dictionary, Merriam-Webster.

[AHD-6] Houghton Mifflin Harcourt, The American Heritage Dictionary of the English Language, Houghton Mifflin Harcourt, archived from the original on 2015-09-25, retrieved 2015-09-25.

[MWU-7] Merriam-Webster, Merriam-Webster's Unabridged Dictionary, Merriam-Webster, archived from the original on 2020-05-25, retrieved 2022-02-10.

[8] Encyclopedia of Endocrine Diseases (in ଇଂରାଜୀ). Academic Press. 2018. p. 344. ISBN 9780128122006.

[autogen2-9] ୯.୦ ^୯.୧ ^୯.୨ "Calcitriol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 9 April 2019.

[BNF76-10] ୧୦.୦ ^୧୦.୧ ^୧୦.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.

[autogen3-11] ୧୧.୦ ^୧୧.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 1050–1051. ISBN 9780857113382.

[ref-12] "CY 2016 Outlier Services" (PDF). Retrieved 13 April 2019.

[ref1-13] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref2-14] "Calcitriol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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Clinical data


Pronunciation	US: /ˌkælsɪˈtraɪɒl/;^[୩]^[୪]^[୫]^[୬]^[୭] UK: /kælˈsɪtriɒl/
Trade names	Rocaltrol, Calcijex, Decostriol, others
Synonyms	1,25-dihydroxycholecalciferol, 1alpha,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D₃, 1α,25-(OH)₂D₃, 1,25(OH)₂D^[୨]
AHFS/Drugs.com	monograph
MedlinePlus	a682335
data	US DailyMed: Calcitriol
Pregnancy category	AU: B3 US: C (Risk not ruled out)
Routes of administration	By mouth, IV^[୧]
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	99.9%
Metabolism	Kidney
Elimination half-life	5–8 hours (adults), 27 hours (children)
Excretion	Faeces (50%), urine (16%)
Identifiers
IUPAC name (1R,3S)-5-[2-[(1R,3aR,7aS)-1-[(2R)-6-hydroxy-6-methyl-heptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H- inden-4-ylidene]ethylidene]-4-methylidene-cyclohexane-1,3-diol
ECHA InfoCard	100.046.315
Chemical and physical data
Formula	C₂₇H₄₄O₃
Molar mass	୪୧୬.୬୫ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1^Y Key:GMRQFYUYWCNGIN-NKMMMXOESA-N^Y
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