କାର୍ଫିଲଜୋମିବ

କାର୍ଫିଲଜୋମିବ
Clinical data
Trade names	Kyprolis
Synonyms	PX-171-007
AHFS/Drugs.com	monograph
MedlinePlus	a612031
data	EU EMA: yes; US DailyMed: Carfilzomib;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	97%
Metabolism	Extensive; CYP plays a minor role
Identifiers
	IUPAC name (2S)-4-Methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide;
ECHA InfoCard	100.219.957
Chemical and physical data
Formula	C40H57N5O7
Molar mass	୭୧୯.୯୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)[C@@]1(OC1)C)CC(C)C)Cc2ccccc2)CC(C)C)CCc3ccccc3)CN4CCOCC4;
	InChI InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1; Key:BLMPQMFVWMYDKT-NZTKNTHTSA-N;

କାର୍ଫିଲଜୋମିବ, ଏକ ବେପାର ନାମ କିପ୍ରୋଲିସ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମଲ୍ଟିପ୍ଲ ମାଇଲୋମା ( MM) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୨] ଅନ୍ୟାନ୍ୟ ଚିକିତ୍ସାରେ ଉନ୍ନତି କରିନଥିବା ଅବସ୍ଥାରେ ଏହା ବ୍ୟବହୃତ ହୁଏ । ^[୩] ଏହା ଶିରାରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ଲୋହିତ ରକ୍ତ କଣିକା, ଥକ୍କା, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, କମ୍ ପ୍ଲାଟେଲେଟ୍, ଜ୍ୱର, ଅଣନିଶ୍ୱାସ, କାଶ ଏବଂ ନିମ୍ନ ଶ୍ୱେତ ରକ୍ତ କଣିକା ହୋଇପାରେ । ^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦଘାତ, ଯକୃତ ସମସ୍ୟା, ଫୁସଫୁସ ସମସ୍ୟା, ବୃକ୍‌କ ସମସ୍ୟା, ରକ୍ତସ୍ରାବ, ସଂକ୍ରମଣ ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୫] ଏହା ଏକ ପ୍ରୋଟିଜୋମ ଅବରୋଧକାରୀ ଔଷଧ | ^[୨]

୨୦୧୨ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୧୫ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ନିମନ୍ତେ କାର୍ଫିଲଜୋମିବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪]^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ମସିହାରେ ଏହାର ମୂଲ୍ୟ ୧୦୫୦ ପାଉଣ୍ଡ ଥିଲା । ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୨,୭୦୦ ଡଲାର । ^[୬]

ଆଧାର ସମ୍ପାଦନା

↑ ^୧.୦ ^୧.୧ "Kyprolis- carfilzomib injection, powder, lyophilized, for solution". DailyMed. 26 August 2020. Archived from the original on 12 August 2020. Retrieved 13 November 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Carfilzomib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 June 2021. Retrieved 30 December 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1008. ISBN 978-0857114105.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Kyprolis". Archived from the original on 14 November 2021. Retrieved 30 December 2021.
↑ "DailyMed - KYPROLIS- carfilzomib injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 12 August 2020. Retrieved 30 December 2021.
↑ "Kyprolis Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 February 2018. Retrieved 30 December 2021.

[Kyprolis_FDA_label-1] ୧.୦ ^୧.୧ "Kyprolis- carfilzomib injection, powder, lyophilized, for solution". DailyMed. 26 August 2020. Archived from the original on 12 August 2020. Retrieved 13 November 2020.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ "Carfilzomib Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 June 2021. Retrieved 30 December 2021.

[BNF81-3] ୩.୦ ^୩.୧ ^୩.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1008. ISBN 978-0857114105.

[EPAR2021-4] ୪.୦ ^୪.୧ ^୪.୨ "Kyprolis". Archived from the original on 14 November 2021. Retrieved 30 December 2021.

[PI2021-5] "DailyMed - KYPROLIS- carfilzomib injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 12 August 2020. Retrieved 30 December 2021.

[6] "Kyprolis Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 February 2018. Retrieved 30 December 2021.

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