ଏପିରୁବିସିନ

ଏପିରୁବିସିନ
Clinical data
Pronunciation	ep” i roo’ bi sin
Trade names	Ellence, Pharmorubicin, Epirubicin Ebewe, others
Synonyms	Epirubicin hydrochloride
AHFS/Drugs.com	monograph
MedlinePlus	a603003
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	NA
Protein binding	77%
Metabolism	Liver glucuronidation and oxidation
Excretion	Biliary and kidney
Identifiers
	IUPAC name (8S,10S)-10-{[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione;
Chemical and physical data
Formula	C27H29NO11
Molar mass	୫୪୩.୫୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2c1c(O)c5c(c(O)c1C(=O)c3cccc(OC)c23)C[C@@](O)(C(=O)CO)C[C@@H]5O[C@@H]4O[C@H]([C@H](O)[C@@H](N)C4)C;
	InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1 ; Key:AOJJSUZBOXZQNB-VTZDEGQISA-N ;
(verify)

ଏପିରୁବିସିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏଲେନ୍ସ ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ସ୍ତନ କର୍କଟ, ପାକସ୍ଥଳୀ କର୍କଟ, ଛୋଟ କୋଷ ଫୁସଫୁସ କର୍କଟ, ଓଭାରି କର୍କଟ, ବୃହଦନ୍ତ୍ର-ମଳାଶୟ କର୍କଟ, ଲିମ୍ଫୋମା, ମୂତ୍ରାଶୟ କର୍କଟ ଏବଂ ଲିଉକେମିଆ ଇତ୍ୟାଦି ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୨] ^[୩] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ କିମ୍ବା ମୂତ୍ରାଶୟରେ ଭର୍ତ୍ତି କରାଯାଏ ।^[୨] ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କେଶହାନୀ, ଅଇ, ଅସ୍ଥି ମଜ୍ଜା ଦମନ, ପାଟିର ପ୍ରଦାହ, ଗରମ ଫ୍ଲସ୍, ତରଳ ଝାଡ଼ା, ସଂକ୍ରମଣ, ରାସ, ଓ ଜ୍ୱର ହୋଇପାରେ । ^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃତ୍‌ପିଣ୍ଡ ନଷ୍ଟ, ଅନୁର୍ବରତା, ଅଧିକ କର୍କଟ ରୋଗ ଏବଂ ଟ୍ୟୁମର ଲାଇସିସ୍ ସିଣ୍ଡ୍ରୋମ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୨] ଏହା ଏକ ଆନ୍ଥ୍ରାସାଇକ୍ଲିନ୍ ଯାହା ଡିଏନଏ ସୁତ୍ରମାନଙ୍କୁ (DNA ଷ୍ଟ୍ରାଣ୍ଡକୁ) ଇଣ୍ଟରକାଲେଟିଙ୍ଗ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ଯାହାଫଳରେ ଡିଏନଏ ପ୍ରସ୍ତୁତିର ଅବରୋଧ ହୁଏ । ^[୧]

୧୯୯୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏପିରୁବିସିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୩] ଯୁକ୍ତରାଜ୍ୟରେ ୫୦ ମିଗ୍ରାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ୮୭ ପାଉଣ୍ଡ ଥିଲା ।^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୬୦ ଡଲାର ଅଟେ । ^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Doxorubicin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 16 May 2021. Retrieved 15 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "EpiRUBicin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 June 2021. Retrieved 15 December 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 947. ISBN 978-0857114105.
↑ "Epirubicin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 April 2021. Retrieved 15 December 2021.

[Liv2021-1] ୧.୦ ^୧.୧ "Doxorubicin". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 16 May 2021. Retrieved 15 December 2021.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "EpiRUBicin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 June 2021. Retrieved 15 December 2021.

[BNF81-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 947. ISBN 978-0857114105.

[4] "Epirubicin Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 April 2021. Retrieved 15 December 2021.

[୨]

[୩]

[୧]

[୪]

Clinical data


Pronunciation	ep” i roo’ bi sin^[୧]
Trade names	Ellence, Pharmorubicin, Epirubicin Ebewe, others
Synonyms	Epirubicin hydrochloride
AHFS/Drugs.com	monograph
MedlinePlus	a603003
Pregnancy category	AU: D US: D (Evidence of risk)
Routes of administration	Intravenous
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	NA
Protein binding	77%
Metabolism	Liver glucuronidation and oxidation
Excretion	Biliary and kidney
Identifiers
IUPAC name (8S,10S)-10-{[(2R,4S,5R,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
Chemical and physical data
Formula	C₂₇H₂₉NO₁₁
Molar mass	୫୪୩.୫୩ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C2c1c(O)c5c(c(O)c1C(=O)c3cccc(OC)c23)C[C@@](O)(C(=O)CO)C[C@@H]5O[C@@H]4O[C@H]([C@H](O)[C@@H](N)C4)C
InChI InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1^Y Key:AOJJSUZBOXZQNB-VTZDEGQISA-N^Y
(verify)