ଆସାଇକ୍ଲୋଭିର

ଆସାଇକ୍ଲୋଭିର (INN)
Clinical data
Pronunciation	/eɪˈsaɪkl[invalid input: 'ɵ']vɪər/
Trade names	Zovirax, others
Synonyms	acycloguanosine
AHFS/Drugs.com	monograph
MedlinePlus	a681045
data	US FDA: Acyclovir;
Pregnancy; category	AU: B3 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Intravenous, oral, topical (including eye ointment)
ATC code	J05AB01 (WHO) D06BB03 S01AD03;
Legal status
Legal status	AU: S4 (Prescription only) for tablet and injection. Unscheduled for cream form under 10 g.; CA: ℞-only ; UK: POM (Prescription only) for tablet and injection. GSL (OTC) for cream form under 2 g.; US: ℞-only ;
Pharmacokinetic data
Bioavailability	15–20% (oral)
Protein binding	9–33%
Metabolism	Hepatic
Elimination half-life	2-4 hours
Excretion	Renal (62-90% as unchanged drug)
Identifiers
	IUPAC name 2-Amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-6H-purin-6-one;
CAS Number	59277-89-3 ;
PubChem CID	2022;
IUPHAR/BPS	4829;
DrugBank	DB00787 ;
ChemSpider	1945 ;
UNII	X4HES1O11F;
KEGG	D00222 ;
ChEBI	CHEBI:2453 ;
ChEMBL	CHEMBL184 ;
PDB ligand	AC2 (PDBe, RCSB PDB);
ECHA InfoCard	100.056.059
Chemical and physical data
Formula	C8H11N5O3
Molar mass	୨୨୫.୨୧ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	256.5 °C (493.7 °F)
	SMILES O=C2/N=C(\Nc1n(cnc12)COCCO)N;
	InChI InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) ; Key:MKUXAQIIEYXACX-UHFFFAOYSA-N ;
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ଆସାଇକ୍ଲୋଭିର, ଅନ୍ୟ ନାମ ଏସିକ୍ଲୋଭିର ବା ଆସାଇକ୍ଲୋଗୁଆନୋସିନ ଏକ ପ୍ରକାର ଭୁତାଣୁନିରୋଧି ଔଷଧ^[୩] ପ୍ରଥମିକ ଭାବରେ ଏହା ସାମାନ୍ୟ ହର୍ପିସ ଭୁତାଣୁ (herpes simplex virus), ହାଡ଼ଫୁଟି, ଓ ହର୍ପିସ ଜୋସ୍ଟର ସଂକ୍ରମଣ ନିମନ୍ତେ ବ୍ୟବ‌ହୃତ ହେଉଥିଲା । ଅନ୍ୟାନ୍ୟ ବ୍ୟବ‌ହାର ମଧ୍ୟରେ ପ୍ରତିରୋପ ପରବର୍ତ୍ତୀ ସାଇଟୋମେଗାଲୋଭୁତାଣୁ ଓ ଏପସ୍ଟେନ-ବାର ଭୁତାଣୁ ସଂକ୍ରମଣ ମୂଖ୍ୟ । ଏହା ପାଟି ନିମନ୍ତେ ଓ ଶୀରାରେ ଦେବା ନିମନ୍ତେ ଥାଏ । ^[୪]

ଏହାର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ଅଇ ଓ ତରଳ ଝାଡ଼ା ମୂଖ୍ୟ । ସାଂଘାତିକ ସଂଭାବ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ବୃକ୍‌କ ସମସ୍ୟା ଓ ଥ୍ରୋମ୍ବୋସାଇଟୋପେନିଆ ଉଲ୍ଲେଖ‌ଯୋଗ୍ୟ । ବୃକ୍‌କ ଓ ଯକୃତ ସମସ୍ୟା ଥିଲେ ସାବଧାନତା ସ‌ହ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ କୌଣସି ସମସ୍ୟା ଦେଖାନଥିବାଲୁ ଏହା ନିରାପଦ ମନେ କରାଯାଏ । ^[୪]^[୫] ସ୍ତନ୍ୟପାନ ସମ‌ୟରେ ଏହ ନିରାପଦ । ^[୬] ଆସାଇକ୍ଲୋଭିର ଏକ ନ୍ୟୁକ୍ଲିକଏସିଡ ଆନାଲଗ ଯାହା ଗୁଅନୋସିନରୁ ପ୍ରସ୍ତୁତ ହୋଇଥାଏ । ଭୁତାଣୁର ଡିଏନଏ ପ୍ରସ୍ତୁତି କମେଇ ଏହା କାର୍ଯ୍ୟକାରୀ ହୁଏ ।^[୪]

ସନ ୧୯୭୭ରେ ଏହି ଔଷଧର ଆବିଷ୍କାର କଥା ପ୍ରଚାରିତ ହୋଇଥିଲା । ^[୭] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୮] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ଓ ବଜାରରେ ଅନେକ ବ୍ରାଣ୍ଡ ନାମରେ ମିଳେ । ^[୧] ଏହାର ଡୋଜ ପିଛା ମୂଲ୍ୟ ୦.୦୩ରୁ ୦.୧୨ ଆମେରିକୀୟ ଡଲାର ।^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏକ ଡୋଜର ମୂଲ୍ୟ ୦.୫୦ ଡଲାର । ^[୪]^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Aciclovir". Drugs.com. Retrieved 6 September 2015.
↑ ^୨.୦ ^୨.୧ "Zovirax (acyclovir) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 5 February 2014.
↑ de Clercq, Erik; Field, Hugh J (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". British Journal of Pharmacology. Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11. doi:10.1038/sj.bjp.0706446. PMC 1615839. PMID 16284630.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Acyclovir". The American Society of Health-System Pharmacists. Retrieved Jan 1, 2015.
↑ "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.
↑ ^୬.୦ ^୬.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 59. ISBN 9781284057560.
↑ Clercq, edited by Erik De (2013). Anti-viral agents (1 ed.). San Diego, CA: Academic Press. p. 5. ISBN 9780124055377. {{cite book}}: |first1= has generic name (help)
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Aciclovir". International Drug Price Indicator Guide. Archived from the original on 5 March 2017. Retrieved 6 September 2015.

[Names-1] ୧.୦ ^୧.୧ "Aciclovir". Drugs.com. Retrieved 6 September 2015.

[MSR-2] ୨.୦ ^୨.୧ "Zovirax (acyclovir) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 5 February 2014.

[deClercq2005-3] Clercq, Erik; Field, Hugh J (5 October 2005). "Antiviral prodrugs – the development of successful prodrug strategies for antiviral chemotherapy". British Journal of Pharmacology. Vol. 147, no. 1. Wiley-Blackwell (published January 2006). pp. 1–11. doi:10.1038/sj.bjp.0706446. PMC 1615839. PMID 16284630.

[AHFS2015-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Acyclovir". The American Society of Health-System Pharmacists. Retrieved Jan 1, 2015.

[5] "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.

[Ric2015-6] ୬.୦ ^୬.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 59. ISBN 9781284057560.

[7] Clercq, edited by Erik De (2013). Anti-viral agents (1 ed.). San Diego, CA: Academic Press. p. 5. ISBN 9780124055377. {{cite book}}: |first1= has generic name (help)

[8] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[ERC2014-9] "Aciclovir". International Drug Price Indicator Guide. Archived from the original on 5 March 2017. Retrieved 6 September 2015.

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