ଆର୍ମୋଡାଫିନିଲ

ଆର୍ମୋଡାଫିନିଲ
Clinical data
Pronunciation	ar" moe daf' i nil
Trade names	Nuvigil, others
AHFS/Drugs.com	monograph
MedlinePlus	a602016
Pregnancy; category	C;
Dependence; liability	Low
Routes of; administration	Oral (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; US: Schedule IV ;
Pharmacokinetic data
Metabolism	Liver, including CYP3A4 and other pathways
Elimination half-life	12–15 hours
Excretion	Urine (as metabolites)
Identifiers
	IUPAC name (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide;
ECHA InfoCard	100.207.833
Chemical and physical data
Formula	C15H15NO2S
Molar mass	୨୭୩.୩୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)[S@](=O)CC(=O)N;
	InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1 ; Key:YFGHCGITMMYXAQ-LJQANCHMSA-N ;
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ଆର୍ମୋଡାଫିନିଲ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ Nuvigil, ଏକ ଔଷଧ ଯାହା ନିଦ୍ରାବେଶ, ଅବରୋଧକାରୀ ଶୟନ ଶ୍ୱାସରୋଧ ଏବଂ ପାଳି-କାମ ଶୋଇବା ରୋଗ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] କ୍ରନିକ୍ ରୋଗ ସହିତ ଜଡିତ ଥକ୍କାପଣ ପାଇଁ ଏହା ମଧ୍ୟ ଅଧ୍ୟୟନ କରାଯାଇଛି। ^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨] ଏହାର ସୁଖାଭାସ (ଇଉଫୋରିଆ) ପ୍ରଭାବ ପାଇଁ ଚିତ୍ତାକର୍ଷକ ଭାବରେ ବ୍ୟବହୃତ ହୋଇପାରେ | ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଚିନ୍ତା, ଅଇ, ଭୋକ କମିବା, ଦୃତ ହୃଦଗତି ଏବଂ ଶୋଇବା ବ୍ୟାଘାତ ହୋଇପାରେ । ^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅପବ୍ୟବହାର, ସାଇକୋସିସ୍, ଆତ୍ମହତ୍ୟା ଏବଂ ଷ୍ଟିଭେନ୍ସ-ଜନସନ ସିଣ୍ଡ୍ରୋମ ହୋଇପାରେ। ^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୩] ଏହା ହେଉଛି ( ଆର) - (-) - ମୋଡାଫିନିଲ‌ର ମୋଡାଫିନିଲର ଏନାନସିଓମର । ^[୧]

୨୦୦୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଏହାକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା। ^[୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ମାସକୁ ୨୫୦ ମିଗ୍ରା ବଟିକା ୨୦୨୨ ସୁଦ୍ଧା ମୂଲ୍ୟ ପ୍ରାୟ ୩୨ ଡଲାର ଅଟେ । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ କାର୍ଯ୍ୟସୂଚୀ ଚତୁର୍ଥ (scheudule IV) ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ । ^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Modafinil". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 12 February 2021. Retrieved 16 January 2022.
↑ ^୨.୦ ^୨.୧ "Armodafinil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 August 2021. Retrieved 16 January 2022.
↑ "Armodafinil (Nuvigil) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 2021-02-05. Retrieved 2022-01-16.
↑ "DailyMed - ARMODAFINIL tablet". dailymed.nlm.nih.gov. Archived from the original on 16 January 2022. Retrieved 16 January 2022.
↑ "Armodafinil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 October 2020. Retrieved 16 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ "Modafinil". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 12 February 2021. Retrieved 16 January 2022.

[AHFS2022-2] ୨.୦ ^୨.୧ "Armodafinil Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 August 2021. Retrieved 16 January 2022.

[3] "Armodafinil (Nuvigil) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 2021-02-05. Retrieved 2022-01-16.

[PI2022-4] "DailyMed - ARMODAFINIL tablet". dailymed.nlm.nih.gov. Archived from the original on 16 January 2022. Retrieved 16 January 2022.

[5] "Armodafinil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 10 October 2020. Retrieved 16 January 2022.

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Clinical data


Pronunciation	ar" moe daf' i nil^[୧]
Trade names	Nuvigil, others
AHFS/Drugs.com	monograph
MedlinePlus	a602016
Pregnancy category	C
Dependence liability	Low
Routes of administration	Oral (tablets)
Legal status
Legal status	AU: S4 (Prescription only) US: Schedule IV
Pharmacokinetic data
Metabolism	Liver, including CYP3A4 and other pathways
Elimination half-life	12–15 hours
Excretion	Urine (as metabolites)
Identifiers
IUPAC name (–)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide
ECHA InfoCard	100.207.833
Chemical and physical data
Formula	C₁₅H₁₅NO₂S
Molar mass	୨୭୩.୩୫ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)[S@](=O)CC(=O)N
InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1^Y Key:YFGHCGITMMYXAQ-LJQANCHMSA-N^Y
(verify)