ଆମିଫାମ୍ପ୍ରିଡାଇନ

ଆମିଫାମ୍ପ୍ରିଡାଇନ
Clinical data
Trade names	Firdapse, Ruzurgi, Zenas
Synonyms	Amifampridine phosphate, pyridine-3,4-diamine, 3,4-diaminopyridine, 3,4-DAP
AHFS/Drugs.com	monograph; monograph
data	EU EMA: yes; US DailyMed: Amifampridine;
Pregnancy; category	AU: C ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	93–100%
Metabolism	Acetylation to 3-N-acetylamifampridine
Elimination half-life	2.5 hrs (amifampridine); 4 hrs (3-N-acetylamifampridine)
Excretion	Kidney (19% unmetabolized, 74–81% 3-N-acetylamifampridine
Identifiers
	IUPAC name Pyridine-3,4-diamine;
ECHA InfoCard	100.000.201
Chemical and physical data
Formula	C5H7N3
Molar mass	୧୦୯.୧୩ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	218 to 220 °C (424 to 428 °F) decomposes
Solubility in water	24 mg/mL (20 °C)
	SMILES c1cncc(c1N)N;
	InChI InChI=1S/C5H7N3/c6-4-1-2-8-3-5(4)7/h1-3H,7H2,(H2,6,8) ; Key:OYTKINVCDFNREN-UHFFFAOYSA-N ;
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ଆମିଫାମ୍ପ୍ରିଡାଇନ, ବିକ୍ରୟ ନାମ ଫିରଡାପ୍ସ ଏବଂ ରୁଜୁର୍ଗି, ହେଉଛି ଲାମବ-ଇଟନ୍ ମ୍ୟାସଥେନିକ ସିଣ୍ଡ୍ରୋମର (LEMS) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ । ^[୩] ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୫] ଏହା ଦୁଇ ପ୍ରକାର ମିଳେ, ଗୋଟିଏ ଶିଶୁମାନଙ୍କରେ ବ୍ୟବହାର ପାଇଁ ଏବଂ ଅନ୍ୟଟି ବୟସ୍କମାନଙ୍କ ପାଇଁ ନାମିତ । ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କାଲୁଆ, ପେଟ ଯନ୍ତ୍ରଣା, ତରଳ ଝାଡ଼ା ଏବଂ ଅଇ ଲାଗେ । ^[୪] ଦୀର୍ଘ ସମୟ ଧରି କ୍ୟୁଟି (QT) ଥିଲେ, ଅପସ୍ମାର କିମ୍ବା ଆଜମା ରୋଗୀଙ୍କଠାରେ ଏହା ବ୍ୟବହାର କରାଯିବା ଉଚିତ ନୁହେଁ। ^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କରିବାଦ୍ୱାରା ଶିଶୁର କ୍ଷତି ହୋଇଥାଏ । ^[୭] ଏହା ଏକ ପୋଟାସିୟମ୍ ଚ୍ୟାନେଲ୍ ବ୍ଲକର୍ ଯାହା ସ୍ନାୟୁ ଡିପୋଲାରାଇଜେସନ୍ ସମୟକୁ ଦୀର୍ଘ କରିଥାଏ । ^[୪]

୨୦୦୯ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ନିମନ୍ତେ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୪] ^[୩] ଯୁକ୍ତରାଜ୍ୟରେ ୧୦ ମିଗ୍ରାର ୧୦୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ରେ ୧୮୦୦ ପାଉଣ୍ଡ ଥିଲା । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ଓଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦,୬୦୦ ଡଲାର । ^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Ruzurgi". Therapeutic Goods Administration (TGA). 24 September 2021. Archived from the original on 30 September 2021. Retrieved 30 September 2021.
↑ "Firdapse Summary of Product Characteristics" (PDF). EMA. February 11, 2010. Archived (PDF) from the original on June 20, 2018. Retrieved September 30, 2021. See EMA Index page, product tab Archived 2018-09-20 at the Wayback Machine.
↑ ^୩.୦ ^୩.୧ "DailyMed - RUZURGI- amifampridine tablet". dailymed.nlm.nih.gov. Archived from the original on 30 September 2021. Retrieved 14 January 2022.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Firdapse (previously Zenas)". Archived from the original on 14 November 2021. Retrieved 14 January 2022.
↑ ^୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1171. ISBN 978-0857114105.
↑ "Amifampridine Phosphate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 December 2020. Retrieved 14 January 2022.
↑ "Amifampridine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 November 2020. Retrieved 14 January 2022.
↑ "Firdapse Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 14 January 2022.

[Ruzurgi_APM_summary-1] ୧.୦ ^୧.୧ "Ruzurgi". Therapeutic Goods Administration (TGA). 24 September 2021. Archived from the original on 30 September 2021. Retrieved 30 September 2021.

[EMAlabel2010-2] "Firdapse Summary of Product Characteristics" (PDF). EMA. February 11, 2010. Archived (PDF) from the original on June 20, 2018. Retrieved September 30, 2021. See EMA Index page, product tab Archived 2018-09-20 at the Wayback Machine.

[PI2022-3] ୩.୦ ^୩.୧ "DailyMed - RUZURGI- amifampridine tablet". dailymed.nlm.nih.gov. Archived from the original on 30 September 2021. Retrieved 14 January 2022.

[EPAR2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ "Firdapse (previously Zenas)". Archived from the original on 14 November 2021. Retrieved 14 January 2022.

[BNF81-5] ୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1171. ISBN 978-0857114105.

[AHFS2022A-6] "Amifampridine Phosphate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 December 2020. Retrieved 14 January 2022.

[7] "Amifampridine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 November 2020. Retrieved 14 January 2022.

[8] "Firdapse Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 14 January 2022.

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