ଅକ୍ସିଟେଟ୍ରାସାଇକ୍ଲିନ

ଅକ୍ସିଟେଟ୍ରାସାଇକ୍ଲିନ
Clinical data
Trade names	Terramycin
Pregnancy; category	AU: D ; ;
Routes of; administration	By mouth, topical (eye drop)
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Elimination half-life	6–8 hours
Excretion	Kidney
Identifiers
	IUPAC name (4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-3,5,6,10,11,12a-hexahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboxamide;
E number	E703 (antibiotics)
ECHA InfoCard	100.001.103
Chemical and physical data
Formula	C22H24N2O9
Molar mass	୪୬୦.୪୪ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	181 to 182 °C (358 to 360 °F)
	SMILES CN(C)[C@@H]3C(\O)=C(\C(N)=O)C(=O)[C@@]4(O)C(/O)=C2/C(=O)c1c(cccc1O)[C@@](C)(O)[C@H]2[C@H](O)[C@@H]34;
	InChI InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1 ; Key:IWVCMVBTMGNXQD-PXOLEDIWSA-N ;
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ଅକ୍ସିଟେଟ୍ରାସାଇକ୍ଲିନ ହେଉଛି ଏକ ପ୍ରକାର ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ଟ୍ରାକୋମା ସମେତ କ୍ଲାମିଡିଆ, ମାଇକୋପ୍ଲାଜ୍ମା ଏବଂ ରିକେଟ୍ସିଆ ଭଳି ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧]^[୨] ଏହା ବ୍ରଣ ଏବଂ ରୋଜେସିଆ ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ପାଟିରେ ନିଆଯାଏ ।^[୧]ଏକ ଆଖି ମଲମ ଭାବରେ ଏକ ମିଶ୍ରଣ ସୂତ୍ର ମଧ୍ୟ ଉପଲବ୍ଧ ହୁଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ମୁଣ୍ଡ ବିନ୍ଧା, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ସୂର୍ଯ୍ୟକିରଣ ସମ୍ବେଦନଶୀଳତା ଏବଂ ବାନ୍ତି ହୋଇପାରେ ।^[୧] ୧୨ ବର୍ଷରୁ କମ୍ ବୟସରେ ବ୍ୟବହାର ସାଧାରଣତଃ ଦାନ୍ତରେ ଦାଗ ହେବା ସମ୍ଭାବନା ହେବା ସମ୍ଭାବନ ହେତୁ ଏହା ସୁପାରିଶ କରାଯାଏ ନାହିଁ । ।|^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୧]ଏହା ଏକ ବ୍ରଡ-ସ୍ପେକ୍ଟ୍ରମ ଟେଟ୍ରାସାଇକ୍ଲିନ ଆଣ୍ଟିବାୟୋଟିକ ।^[୪] ଜୀବାଣୁଙ୍କର ପ୍ରୋଟିନ୍ ଉତ୍ପାଦନ କରିବା କ୍ଷମତାକୁ ଅବରୋଧ କରି ଏହା କାମ କରେ ।^[୪]

ଅକ୍ସିଟେଟ୍ରାସାଇକ୍ଲିନ ୧୯୪୯ରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୫୦ରେ ବ୍ୟବସାୟିକ ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୫] ଟେଟ୍ରାସାଇକ୍ଲିନର ବିକଳ୍ପ ଭାବରେ ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଲିପିବଦ୍ଧ ଅଛି ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୧୩ ମସିହା ସୁଦ୍ଧା ଏହା ବାବଦରେ ୧.୪୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Oxytetracycline". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 8 September 2023.
↑ "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 4 June 2023. Retrieved 8 September 2023.
↑ "DailyMed - TERRAMYCIN- oxytetracycline hydrochloride and polymyxin b sulfate ointment". dailymed.nlm.nih.gov. Archived from the original on 24 January 2022. Retrieved 8 September 2023.
↑ ^୪.୦ ^୪.୧ "DailyMed - terramycin- Oxytetracycline Hydrochloride capsule". dailymed.nlm.nih.gov. Archived from the original on 28 September 2022. Retrieved 8 September 2023.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 489. ISBN 9783527607495.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ "Oxytetracycline Medicinal forms". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 8 September 2023.

[BNF2023-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Oxytetracycline". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 8 September 2023.

[2] "eEML - Electronic Essential Medicines List". list.essentialmeds.org. Archived from the original on 4 June 2023. Retrieved 8 September 2023.

[3] "DailyMed - TERRAMYCIN- oxytetracycline hydrochloride and polymyxin b sulfate ointment". dailymed.nlm.nih.gov. Archived from the original on 24 January 2022. Retrieved 8 September 2023.

[DM2023-4] ୪.୦ ^୪.୧ "DailyMed - terramycin- Oxytetracycline Hydrochloride capsule". dailymed.nlm.nih.gov. Archived from the original on 28 September 2022. Retrieved 8 September 2023.

[5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 489. ISBN 9783527607495.

[WHO22nd-6] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[7] "Oxytetracycline Medicinal forms". NICE. BNF. Archived from the original on 10 September 2023. Retrieved 8 September 2023.

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Clinical data


Trade names	Terramycin
Pregnancy category	AU: D
Routes of administration	By mouth, topical (eye drop)
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Elimination half-life	6–8 hours
Excretion	Kidney
Identifiers
IUPAC name (4S,4aR,5S,5aR,6S,12aS)-4-(Dimethylamino)-3,5,6,10,11,12a-hexahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,5a,6,12,12a-octahydrotetracene-2-carboxamide
E number	E703 (antibiotics)
ECHA InfoCard	100.001.103
Chemical and physical data
Formula	C₂₂H₂₄N₂O₉
Molar mass	୪୬୦.୪୪ g·mol⁻¹
3D model (JSmol)	Interactive image
Melting point	181 to 182 °C (358 to 360 °F)
SMILES CN(C)[C@@H]3C(\O)=C(\C(N)=O)C(=O)[C@@]4(O)C(/O)=C2/C(=O)c1c(cccc1O)[C@@](C)(O)[C@H]2[C@H](O)[C@@H]34
InChI InChI=1S/C22H24N2O9/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31)/t12-,13-,14+,17+,21-,22+/m1/s1^Y Key:IWVCMVBTMGNXQD-PXOLEDIWSA-N^Y
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