ଥିଆମାଜୋଲ

ଥିଆମାଜୋଲ
Clinical data
Trade names	Tapazole, others
Synonyms	thiamazole (INN, BAN); methimazole (USAN); MMI
AHFS/Drugs.com	monograph
MedlinePlus	a682464
data	US DailyMed: Thiamazole;
Pregnancy; category	D (US);
Routes of; administration	By mouth
ATC code	H03BB02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	93%
Protein binding	None
Metabolism	Liver
Elimination half-life	5-6 hours
Excretion	Kidney
Identifiers
	IUPAC name 1-Methyl-3H-imidazole-2-thione;
CAS Number	60-56-0 ;
PubChem CID	1349907;
IUPHAR/BPS	6649;
DrugBank	DB00763 ;
ChemSpider	1131173 ;
UNII	554Z48XN5E;
KEGG	D00401 ;
ChEBI	CHEBI:50673 ;
ChEMBL	CHEMBL1515 ;
ECHA InfoCard	100.000.439
Chemical and physical data
Formula	C4H6N2S
Molar mass	୧୧୪.୧୭ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	146 °C (295 °F)
Solubility in water	275 mg/mL (20 °C)
	SMILES Cn1cc[nH]c1=S;
	InChI InChI=1S/C4H6N2S/c1-6-3-2-5-4(6)7/h2-3H,1H3,(H,5,7) ; Key:PMRYVIKBURPHAH-UHFFFAOYSA-N ;
(verify)

ଥିଆମାଜୋଲ, ଅନ୍ୟ ନାମ ମିଥିମାଜୋଲ, ଏକ ଔଷଧ ଯାହା ହାଇପରଥାଇରଏଡିଜିମ୍ ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ଏଥିରେ ଗ୍ରେଭସ ରୋଗ, ବିଷାକ୍ତ ମଲ୍ଟିନୋଡ୍ୟୁଲାର ଗଏଟର ଏବଂ ଥାଇରୋଟକ୍ସିକ ଗଏଟର ଅନ୍ତର୍ଭୁକ୍ତ। ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩] ପୂର୍ଣ୍ଣ ପ୍ରଭାବ ଘଟିବାକୁ କିଛି ସପ୍ତାହ ଲାଗିପାରେ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗଲୁ, କେଶହାନୀ, ଅଇ, ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା, ଫୁଲା ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୋଇପାରେ | ^[୨] ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ସଂଖ୍ୟକ ରକ୍ତ କଣିକା, ଯକୃତ ବିଫଳତା, ଏବଂ ଭାସ୍କୁଲାଇଟିସ ହୋଇପାରେ। ^[୩] ଗର୍ଭାବସ୍ଥାର ପ୍ରଥମ ତ୍ରେମାସିକରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ କିନ୍ତୁ ଦ୍ୱିତୀୟ ତ୍ରେମାସିକ କିମ୍ବା ତୃତୀୟ ତ୍ରୈମାସିକରେ ବ୍ୟବହୃତ ହୋଇପାରେ | ^[୫] ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ | ^[୬] ଗୁରୁତ୍ୱପୂର୍ଣ୍ଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହୋଇଥିଲେ ପ୍ରୋପାଇଲଥାୟୋୟୁରାସିଲ୍ ସହିତ ଅସୁବିଧାର ସମ୍ମୁଖୀନ ହୋଇପାରନ୍ତି | ^[୩] ଥିଆମାଜୋଲ ହେଉଛି ଏକ ଥିଓମାଇଡ ଶ୍ରେଣୀର ଔଷଧ ଏବଂ ଥାଇରଏଡ ହରମୋନ ଉତ୍ପାଦନ ହ୍ରାସ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୩]

୧୯୫୦ ମସିହାର ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଥିଆମାଜୋଲ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୨] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି । ^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ଯୋଗାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୬.୮୦ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୮] ଏହା ୟୁରୋପ ଏବଂ ଏସିଆରେ ମଧ୍ୟ ଉପଲବ୍ଧ | ^[୯] ୨୦୧୭ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୪୪ ତମ ସାଧାରଣତ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଏକ ମିଲିୟନରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୦] ^[୧୧]

ଆଧାର

↑ "DrugBank: Methimazole (DB00763)". drugbank.ca. Retrieved 21 July 2015.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 July 2019. Retrieved 8 April 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 July 2019. Retrieved 8 April 2019.
↑ Spina, Domenico (2008). The Flesh and Bones of Medical Pharmacology E-Book. Elsevier Health Sciences. p. 74. ISBN 9780723437161. Archived from the original on 29 August 2021. Retrieved 8 April 2019.
↑ "Methimazole Use During Pregnancy". Drugs.com. Archived from the original on 8 April 2019. Retrieved 8 April 2019.
↑ "Methimazole Use During Pregnancy". Drugs.com. Archived from the original on 8 April 2019. Retrieved 8 April 2019.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
↑ Jastrzębska, Helena (2015). "Antithyroid drugs". Thyroid Research. 8 (Suppl 1): A12. doi:10.1186/1756-6614-8-S1-A12. PMC 4480840.{{cite journal}}: CS1 maint: unflagged free DOI (link)
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
↑ "Methimazole - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

[1] "DrugBank: Methimazole (DB00763)". drugbank.ca. Retrieved 21 July 2015.

[AHFS2019-2] ୨.୦ ^୨.୧ ^୨.୨ "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 July 2019. Retrieved 8 April 2019.

[autogen3-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Methimazole Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 17 July 2019. Retrieved 8 April 2019.

[4] Spina, Domenico (2008). The Flesh and Bones of Medical Pharmacology E-Book. Elsevier Health Sciences. p. 74. ISBN 9780723437161. Archived from the original on 29 August 2021. Retrieved 8 April 2019.

[Pref2019-5] "Methimazole Use During Pregnancy". Drugs.com. Archived from the original on 8 April 2019. Retrieved 8 April 2019.

[autogen1-6] "Methimazole Use During Pregnancy". Drugs.com. Archived from the original on 8 April 2019. Retrieved 8 April 2019.

[WHO21st-7] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.

[9] Jastrzębska, Helena (2015). "Antithyroid drugs". Thyroid Research. 8 (Suppl 1): A12. doi:10.1186/1756-6614-8-S1-A12. PMC 4480840.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[ref-10] "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.

[ref1-11] "Methimazole - Drug Usage Statistics". ClinCalc. Archived from the original on 8 July 2020. Retrieved 11 April 2020.

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