ଟେଲୋଟ୍ରିଷ୍ଟାଟ

ଟେଲୋଟ୍ରିଷ୍ଟାଟ
Clinical data
Trade names	Xermelo
Synonyms	Telotristat ethyl, LX1032, LX1606
AHFS/Drugs.com	monograph
MedlinePlus	a617029
data	US DailyMed: Telotristat_ethyl;
Pregnancy; category	AU: B3 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	>99% (both telotristat ethyl and telotristat)
Metabolism	Hydrolysis via carboxylesterases
Metabolites	Telotristat
Elimination half-life	0.6 hours (telotristat ethyl), 5 hours (telotristat)
Excretion	Feces (92.8%), urine (less than 0.4%)
Identifiers
	IUPAC name [(S)-Ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate];
Chemical and physical data
Formula	C27H26ClF3N6O3
Molar mass	୫୭୪.୯୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCOC(=O)C(CC1=CC=C(C=C1)C2=CC(=NC(=N2)N)OC(C3=C(C=C(C=C3)Cl)N4C=CC(=N4)C)C(F)(F)F)N;
	InChI InChI=1S/C27H26ClF3N6O3/c1-3-39-25(38)20(32)12-16-4-6-17(7-5-16)21-14-23(35-26(33)34-21)40-24(27(29,30)31)19-9-8-18(28)13-22(19)37-11-10-15(2)36-37/h4-11,13-14,20,24H,3,12,32H2,1-2H3,(H2,33,34,35)/t20-,24+/m0/s1; Key:MDSQOJYHHZBZKA-GBXCKJPGSA-N;

ଟେଲୋଟ୍ରିଷ୍ଟାଟ (ଇଂରାଜୀ ଭାଷାରେ Telotristat), ଜେରମେଲୋ (Xermelo) ଏହାର ଏକ ବିକ୍ରୟ ନାମ, କାର୍ସିନଏଡ ସିଣ୍ଡ୍ରୋମ ଯୋଗୁ ହେଉଥିବା ତରଳ ଝାଡ଼ା ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୩] ଏହାକୁ ଦିନକୁ ତିନିଥର ପାଟିରେ ଦିଆଯାଏ ।^[୩] ଏହାସୋମାଟୋଷ୍ଟାଟିନ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ଯକୃତ ସମସ୍ୟା ଏବଂ ଥକାପଣ ହୋଇପାରେ ।^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ ।^[୩] ଯକୃତ ଜନିତ ସମସ୍ୟାରେ ଛୋଟ ମାତ୍ରା ଆବଶ୍ୟକ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କରିବା ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୪] ଏହା ଟ୍ରିପ୍ଟୋଫେନ ହାଇଡ୍ରୋକ୍ସିଲେଜକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ଯାହାଦ୍ୱାରା ସେରୋଟୋନିନ ଉତ୍ପାଦନ କମିଯାଏ | ^[୩] ^[୧]

୨୦୧୭ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଟେଲୋଟ୍ରିଷ୍ଟାଟ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୩] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ମାସକୁ ଏହାର ଖର୍ଚ୍ଚ ବାବଦ ପ୍ରାୟ ୮୦୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୧୧୦୦ ପାଉଣ୍ଡ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Xermelo EPAR". European Medicines Agency (EMA). Archived from the original on 29 December 2019. Retrieved 17 April 2020.
↑ ^୨.୦ ^୨.୧ "Xermelo- telotristat ethyl tablet". DailyMed. 30 October 2020. Archived from the original on 12 November 2020. Retrieved 11 November 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Telotristat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 25 September 2021.
↑ ^୪.୦ ^୪.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 938. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Xermelo Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 25 September 2021.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Xermelo EPAR". European Medicines Agency (EMA). Archived from the original on 29 December 2019. Retrieved 17 April 2020.

[Xermelo_FDA_label-2] ୨.୦ ^୨.୧ "Xermelo- telotristat ethyl tablet". DailyMed. 30 October 2020. Archived from the original on 12 November 2020. Retrieved 11 November 2020.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Telotristat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 March 2021. Retrieved 25 September 2021.

[BNF80-4] ୪.୦ ^୪.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 938. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[5] "Xermelo Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 25 September 2021.

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