ଟେକୋଭିରିମାଟ

ଟେକୋଭିରିମାଟ
Clinical data
Trade names	Tpoxx
Synonyms	ST-246
AHFS/Drugs.com	monograph
data	US DailyMed: Tecovirimat;
Routes of; administration	By mouth, intravenous
ATC code	J05AX24 (WHO) ;
Legal status
Legal status	CA: ℞-only ; US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name N-{3,5-Dioxo-4-azatetracyclo[5.3.2.0{2,6}.0{8,10}]dodec-11-en-4- yl}-4-(trifluoromethyl)benzamide;
CAS Number	869572-92-9;
PubChem CID	16124688;
DrugBank	DB12020;
ChemSpider	17281586 ;
UNII	F925RR824R;
KEGG	D09390 ; as monohydrate: D11557 ;
ChEMBL	CHEMBL1257073 ;
Chemical and physical data
Formula	C19H15F3N2O3
Molar mass	୩୭୬.୩୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1ccc(cc1)C(=O)NN1C(=O)C2C(C3C=CC2C2CC32)C1=O;
	InChI InChI=1S/C19H15F3N2O3/c20-19(21,22)9-3-1-8(2-4-9)16(25)23-24-17(26)14-10-5-6-11(13-7-12(10)13)15(14)18(24)27/h1-6,10-15H,7H2,(H,23,25) ; Key:CSKDFZIMJXRJGH-UHFFFAOYSA-N ;

ଟେକୋଭିରିମାଟ (ଇଂରାଜୀ ଭାଷାରେ Tecovirimat), Tpoxx ଏହାର ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଭୂରାଣୁରୋଧୀ ଔଷଧ ଯାହା ବସନ୍ତ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୬] ଅନ୍ୟାନ୍ୟ ବ୍ୟବହାରରେ ମଙ୍କିପକ୍ସ, କାଓପକ୍ସ ଏବଂ ବସନ୍ତ ଟିକା ଇତ୍ୟାଦି ରୋଗମାନ ଜଟିଳ ହେଲେ ଦିଆଯାଏ ।^[୭] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୬] ଏହାର କୌଣସି ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଦେଖାଯାଇ ନାହିଁ ।^[୮] ଏହା ଅର୍ଥୋପକ୍ସଭୂତାଣୁ ଭିପି୩୭ (VP37) ପ୍ରୋଟିନ‌କୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ଯାହା ଭୂତାଣୁକୁ ଜୀବକୋଷ ଛାଡିବାକୁ ରୋକିଥାଏ ।^[୬]

୨୦୧୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ବସନ୍ତ ରୋଗ ପାଇଁ ବ୍ୟବହାର କରିବାକୁ ଟେକୋଭିରିମାଟ ପ୍ରଥମ ଔଷଧ ଭାବରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ^[୯] ଦୈବାତ୍ ବସନ୍ତ ରୋଗର ପୁନଃ ଆବିର୍ଭାବ ହେଲେ ଯୁକ୍ତରାଷ୍ଟ୍ରର ଷ୍ଟ୍ରାଟେଜିକ୍ ନ୍ୟାସନାଲ ଷ୍ଟକପାଇଲରେ (Strategic National Stockpile) ତାହାର ଚିକିତ୍ସା ନିମନ୍ତେ ଦୁଇ ନିୟୁତ ମାତ୍ରା ଗଚ୍ଛିତ ଅଛି ।^[୧୦] ୨୦୨୧ ସୁଦ୍ଧା ଏହା ୟୁରୋପରେ ଅନୁମୋଦିତ ହୋଇ ନାହିଁ ।^[୭]

ଆଧାର

↑ "Notice: Multiple Additions to the Prescription Drug List (PDL) [2022-01-24]". Health Canada. 24 January 2022. Archived from the original on 29 May 2022. Retrieved 28 May 2022.
↑ "New Medicines Approved in 2018". Health Canada. 15 January 2020. Archived from the original on 29 May 2022. Retrieved 28 May 2022.
↑ "Summary Basis of Decision (SBD) for Tpoxx". Health Canada. 23 October 2014. Archived from the original on 29 May 2022. Retrieved 29 May 2022.
↑ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; Tecovirimat SIGA EPAR ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।
↑ "Tpoxx- tecovirimat monohydrate capsule". DailyMed. 2 December 2021. Archived from the original on 23 April 2022. Retrieved 23 April 2022.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Tecovirimat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 24 September 2021.
↑ ^୭.୦ ^୭.୧ "Tecovirimat". SPS - Specialist Pharmacy Service. 17 July 2018. Archived from the original on 31 July 2020. Retrieved 24 September 2021.
↑ McNeil Jr DG. "Drug to Treat Smallpox Approved by F.D.A., a Move Against Bioterrorism". The New York Times. Archived from the original on 28 March 2019. Retrieved 16 July 2018.
↑ Bonville, Cynthia; Domachowske, Joseph (2021). "28. Smallpox". In Domachowske, Joseph; Suryadevara, Manika (eds.). Vaccines: A Clinical Overview and Practical Guide (in ଇଂରାଜୀ). Switzerland: Springer. p. 337. ISBN 978-3-030-58416-0. Archived from the original on 3 June 2022. Retrieved 1 June 2022.
↑ Cunningham A (13 July 2018). "FDA approves the first smallpox treatment". Archived from the original on 12 July 2018. Retrieved 1 July 2021.

[auto-1] "Notice: Multiple Additions to the Prescription Drug List (PDL) [2022-01-24]". Health Canada. 24 January 2022. Archived from the original on 29 May 2022. Retrieved 28 May 2022.

[2] "New Medicines Approved in 2018". Health Canada. 15 January 2020. Archived from the original on 29 May 2022. Retrieved 28 May 2022.

[3] "Summary Basis of Decision (SBD) for Tpoxx". Health Canada. 23 October 2014. Archived from the original on 29 May 2022. Retrieved 29 May 2022.

[Tecovirimat_SIGA_EPAR-4] ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; Tecovirimat SIGA EPAR ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।

[Tpoxx_FDA_label-5] "Tpoxx- tecovirimat monohydrate capsule". DailyMed. 2 December 2021. Archived from the original on 23 April 2022. Retrieved 23 April 2022.

[AHFS2021-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Tecovirimat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 24 September 2021.

[SPS2021-7] ୭.୦ ^୭.୧ "Tecovirimat". SPS - Specialist Pharmacy Service. 17 July 2018. Archived from the original on 31 July 2020. Retrieved 24 September 2021.

[NYT2018-8] McNeil Jr DG. "Drug to Treat Smallpox Approved by F.D.A., a Move Against Bioterrorism". The New York Times. Archived from the original on 28 March 2019. Retrieved 16 July 2018.

[Domachowske2021-9] Bonville, Cynthia; Domachowske, Joseph (2021). "28. Smallpox". In Domachowske, Joseph; Suryadevara, Manika (eds.). Vaccines: A Clinical Overview and Practical Guide (in ଇଂରାଜୀ). Switzerland: Springer. p. 337. ISBN 978-3-030-58416-0. Archived from the original on 3 June 2022. Retrieved 1 June 2022.

[10] Cunningham A (13 July 2018). "FDA approves the first smallpox treatment". Archived from the original on 12 July 2018. Retrieved 1 July 2021.

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