ପ୍ରୋକ୍ଲୋରପେରାଜିନ

ପ୍ରୋକ୍ଲୋରପେରାଜିନ
Clinical data
Trade names	Compro, others
AHFS/Drugs.com	monograph
MedlinePlus	a682116
Pregnancy; category	C (Au, U.S.);
Routes of; administration	By mouth, rectal, IM, IV
ATC code	N05AB04 (WHO) ;
Legal status
Legal status	AU: S3 (Pharmacist only) ; UK: POM (Prescription only) but packs of 8 buccal tablets for nausea/vomiting associated with migraine are sold as pharmacy medicines; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Unknown, but presumed substantial
Protein binding	91–99%
Metabolism	Mainly hepatic (CYP2D6 and/or CYP3A4)
Elimination half-life	4–8 hours, differs with the method of administration
Excretion	Biliary, (colored) inactive metabolites in urine
Identifiers
	IUPAC name 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine;
CAS Number	58-38-8 ;
PubChem CID	4917;
IUPHAR/BPS	7279;
DrugBank	DB00433 ;
ChemSpider	4748 ;
UNII	YHP6YLT61T;
KEGG	D00493 ;
ChEBI	CHEBI:8435 ;
ChEMBL	CHEMBL728 ;
ECHA InfoCard	100.000.345
Chemical and physical data
Formula	C20H24ClN3S
Molar mass	373.943 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc2cc1N(c3c(Sc1cc2)cccc3)CCCN4CCN(C)CC4;
	InChI InChI=1S/C20H24ClN3S/c1-22-11-13-23(14-12-22)9-4-10-24-17-5-2-3-6-19(17)25-20-8-7-16(21)15-18(20)24/h2-3,5-8,15H,4,9-14H2,1H3 ; Key:WIKYUJGCLQQFNW-UHFFFAOYSA-N ;
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ପ୍ରୋକ୍ଲୋରପେରାଜିନ (ଇଂରାଜୀ ଭାଷାରେ Prochlorperazine, ଏକ ବିକ୍ରୟ ନାମ କମ୍ପ୍ରୋ/Compro) ଏକ ଔଷଧ ଯାହା ଅଇ (nausea), ସିଜୋଫ୍ରେନିଆ , ଅଧକପାଳି ଓ ଉଦ୍‌ବେଗ ଆଦି ରୋଗରେ ଦିଆଯାଏ ।^[୧]^[୨]^[୩] ଉଦ୍‌ବେଗ ରୋଗରେ ଏହା କମ୍ ପସନ୍ଦ କରାଯାଏ ।^[୧] ଏହା ପାଟିରେ, ମଳଦ୍ୱାରରେ (rectally), ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ (injection into a vein) ବା ମାଂସପେଶୀ ଇଞ୍ଜେକସନ (injection into a muscle) ଆକାରରେ ଦିଆଯାଏ ।^[୧]

ପ୍ରୋକ୍ଲୋରପେରାଜିନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ଝାପ୍‌ସା ଦୃଷ୍ଟି, ଅଳ୍ପ ରକ୍ତଚାପ ଓ ମୁଣ୍ଡ ଓଜନିଆ ଲାଗିପାରେ ।^[୧] ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଟାର୍ଡିଭ ଡିସକାଇନେସିଆ ଓ ନିଉରୋଲେପ୍ଟିକ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ ଆଦି ରୋଗ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହା ଦେବାକୁ ନିଷେଧ କରାଯାଏ ।^[୪] ଏହା ଏକ ଆଣ୍ଟିସାଇକୋଟିକ (antisychotic) ଔଷଧ ଓ ମସ୍ତିଷ୍କରେ ଡୋପାମିନ (dopamine) ସ୍ତରକୁ ପ୍ରଭାବିତ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧]

ସନ ୧୯୫୬ରେ ପ୍ରୋକ୍ଲୋରପେରାଜିନ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୧] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୨] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ଡୋଜ ପିଛା ପ୍ରାୟ ୦.୦୪ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା । ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଡୋଜ ବାବଦ ୦.୨୪ ଆମେରିକୀୟ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୫] ସନ ୨୦୧୬ରେ ଏହାର ୧ ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିସନ ତାଲିକାର ୨୮୮ ତମ ସ୍ଥାନରେ ଥଲା । ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Prochlorperazine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 385–386. ISBN 9780857113382.
↑ Orr, SL; Friedman, BW; Christie, S; Minen, MT; Bamford, C; Kelley, NE; Tepper, D (June 2016). "Management of Adults With Acute Migraine in the Emergency Department: The American Headache Society Evidence Assessment of Parenteral Pharmacotherapies". Headache. 56 (6): 911–40. doi:10.1111/head.12835. PMID 27300483.
↑ "Prochlorperazine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Prochlorperazine. MedlinePlus. U.S. National Library of Medicine. National Institutes of Health.
Prochlorperazine. Hazardous Substances Data Bank (HSDB). U.S. National Library of Medicine. National Institutes of Health.

[AHFS2019-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Prochlorperazine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[BNF76-2] ୨.୦ ^୨.୧ ^୨.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 385–386. ISBN 9780857113382.

[AHS2016-3] Orr, SL; Friedman, BW; Christie, S; Minen, MT; Bamford, C; Kelley, NE; Tepper, D (June 2016). "Management of Adults With Acute Migraine in the Emergency Department: The American Headache Society Evidence Assessment of Parenteral Pharmacotherapies". Headache. 56 (6): 911–40. doi:10.1111/head.12835. PMID 27300483.

[Preg2019-4] "Prochlorperazine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[NADAC2019-5] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[6] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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