ଅକ୍ସିଟୋସିନ

ଅକ୍ସିଟୋସିନ
Clinical data
Pronunciation	/ˌɒks[invalid input: 'ɨ']ˈtoʊsɪn/
Trade names	Pitocin
AHFS/Drugs.com	monograph
Pregnancy; category	AU: A ; ;
Routes of; administration	Intranasal, IV, IM
ATC code	H01BB02 (WHO) ;
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	30%
Metabolism	liver and other oxytocinases
Elimination half-life	1–6 min (IV); ~2 h (intranasal)
Excretion	Biliary and kidney
Identifiers
	IUPAC name 1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzoyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide;
CAS Number	50-56-6 ;
PubChem CID	439302;
IUPHAR/BPS	2174;
DrugBank	DB00107 ;
ChemSpider	388434 ;
UNII	1JQS135EYN;
KEGG	D00089 ;
ChEBI	CHEBI:7872 ;
ChEMBL	CHEMBL395429 ;
ECHA InfoCard	100.000.045
Chemical and physical data
Formula	C43H66N12O12S2
Molar mass	1007.19 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@@H](N)CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O;
	InChI InChI=1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1 ; Key:XNOPRXBHLZRZKH-DSZYJQQASA-N ;
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ଅକ୍ସିଟୋସିନ (ଓଏକ୍ସଟି) ଏକ ଔଷଧ ଓ ହରମୋନ ।^[୩] ଏହା ଔଷଧ ହିସାବରେ ଜରାୟୁର ସଙ୍କୋଚନ କରେ ଯାହାଦ୍ୱାରା ପ୍ରସବ ଆରମ୍ଭ ହୁଏ ବା ଦୃତ ହୁଏ ଓ ପ୍ରସବୋତ୍ତର ରକ୍ତସ୍ରାବ ବନ୍ଦ ହୁଏ । ଏହା ଅନ୍ତଃପେଶୀ ବା ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୩]

ବେଳେ ବେଳେ ଜରାୟୁର ଅତ୍ୟଧିକ ସଙ୍କୋଚନ ହୁଏ ଯାହା ଯୋଗୁ ଶିଶୁର ଅସୁବିଧା ହୁଏ । ଅଇ ଓ ଅଳ୍ପ ହୃତ୍‌ପିଣ୍ଡ ହାର ଇତ୍ୟାଦି ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ । ଅତ୍ୟଧିକ ଅକ୍ସିଟୋସିନ ଡୋଜ ଦେଲେ ଜଳ ବିଷାୟନ (water intoxication) ଓ ଜରାୟୁ ଫାଟିବା ଇତ୍ୟାଦି ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଦେଖାଯାଇପାରେ । ଆଲର୍ଜି ମଧ୍ୟ ହୋଇପାରେ ।^[୩]

ମସ୍ତିଷ୍କର ଏକ ଅଂଶ ହାଇପୋଥାଲାମସରେ ଏହା ପ୍ରସ୍ତୁତ ହୋଇ ପଛ ପିଟୁଇଟାରି ଗ୍ରନ୍ଥିରେ ସଞ୍ଚିତ ହୋଇରହେ ।^[୪]^[୫] ଯୌନ ପ୍ରଜନନ, ଜନ୍ମ ସମୟରେ ଓ ଜନ୍ମ ପର ସମୟରେ ଏହାର ଭୂମିକା ଅଛି ।^[୬] ପ୍ରସବ ବେଳେ ଜରାୟୁ ଓ ଜରାୟୁଗ୍ରୀବା ପ୍ରସାରିତ ହେଲେ, ସ୍ତନ୍ୟପାନ ସମୟରେ ସ୍ତନାଗ୍ର ଉତ୍ତେଜିତ ହେଲେ ଅକ୍ସିଟୋସିନ ନିର୍ଗତ ହୁଏ ।^[୫] ଏହା ଜନ୍ମରେ ସାହାଯ୍ୟ କରେ, ମାଆ ଓ ଶିଶୁର ବନ୍ଧନ ମଜବୁତ କରେ ଓ କ୍ଷୀର ପ୍ରସ୍ତୁତିରେ ଅଂଶ ଗ୍ରହଣ କରେ ।^[୫]^[୭]

ଅକ୍ସିଟୋସିନ ସନ ୧୯୫୨ରେ ଆବିଷ୍କୃତ ହୋଇଥିଲା ।^[୮] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୯] ସନ୨୦୧୪ରେ ଡୋଜ ପ୍ରତି ମୂଲ୍ୟ ୦.୧୦ରୁ ୦.୫୬ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୧୦]

ଆଧାର

↑ Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–6. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.
↑ Huffmeijer R, Alink LR, Tops M, et al. (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinol. Lett. 33 (1): 21–5. PMID 22467107.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Oxytocin". The American Society of Health-System Pharmacists. Retrieved June 2015. {{cite web}}: Check date values in: |accessdate= (help)
↑ Pubchem. "OXYTOCIN | C43H66N12O12S2 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2015-07-25.
↑ ^୫.୦ ^୫.୧ ^୫.୨ Chiras, Daniel D. (2012). Human biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 9780763783457.
↑ Yang, HP; Wang, L; Han, L; Wang, SC (2013). "Nonsocial functions of hypothalamic oxytocin". ISRN neuroscience. 2013: 179272. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304.{{cite journal}}: CS1 maint: unflagged free DOI (link)
↑ Human Evolutionary Biology. Cambridge University Press. 2010. p. 282. ISBN 9781139789004.
↑ Corey, E.J. (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 9781118361733.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Oxytocin". International Drug Price Indicator Guide. Retrieved 20 December 2015.^{[permanent dead link]}

[pmid22436536-1] Weisman O, Zagoory-Sharon O, Feldman R (September 2012). "Intranasal oxytocin administration is reflected in human saliva". Psychoneuroendocrinology. 37 (9): 1582–6. doi:10.1016/j.psyneuen.2012.02.014. PMID 22436536.

[pmid22467107-2] Huffmeijer R, Alink LR, Tops M, et al. (2012). "Salivary levels of oxytocin remain elevated for more than two hours after intranasal oxytocin administration". Neuro Endocrinol. Lett. 33 (1): 21–5. PMID 22467107.

[AHFS2015-3] ୩.୦ ^୩.୧ ^୩.୨ "Oxytocin". The American Society of Health-System Pharmacists. Retrieved June 2015. {{cite web}}: Check date values in: |accessdate= (help)

[4] Pubchem. "OXYTOCIN | C43H66N12O12S2 - PubChem". pubchem.ncbi.nlm.nih.gov. Retrieved 2015-07-25.

[Chi2012-5] ୫.୦ ^୫.୧ ^୫.୨ Chiras, Daniel D. (2012). Human biology (7th ed.). Sudbury, MA: Jones & Bartlett Learning. p. 262. ISBN 9780763783457.

[6] Yang, HP; Wang, L; Han, L; Wang, SC (2013). "Nonsocial functions of hypothalamic oxytocin". ISRN neuroscience. 2013: 179272. doi:10.1155/2013/179272. PMC 4045544. PMID 24967304.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[7] Human Evolutionary Biology. Cambridge University Press. 2010. p. 282. ISBN 9781139789004.

[8] Corey, E.J. (2012). "Oxytocin". Molecules and Medicine. John Wiley & Sons. ISBN 9781118361733.

[9] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[10] "Oxytocin". International Drug Price Indicator Guide. Retrieved 20 December 2015.^{[permanent dead link]}

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