ଓକ୍ସାମ୍ନିକୁଇନ

ଓକ୍ସାମ୍ନିକୁଇନ
Clinical data
Trade names	Vansil
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	Category C (unclear if it is safe for the unborn baby);
Routes of; administration	by mouth
ATC code	P02BA02 (WHO) QP52AA02 (WHO);
Legal status
Legal status	Not commercially available in the United States;
Pharmacokinetic data
Bioavailability	Readily absorbed when taken by mouth
Metabolism	liver
Elimination half-life	1 to 2.5h
Excretion	mainly in urine
Identifiers
	IUPAC name (RS)-1,2,3,4-Tetrahydro-2-isopropylaminomethyl-7-nitro-6-quinolylmethanol;
CAS Number	21738-42-1 ;
PubChem CID	4612;
DrugBank	DB01096 ;
ChemSpider	4451 ;
UNII	0O977R722D;
KEGG	D00460 ;
ChEBI	CHEBI:7819 ;
ChEMBL	CHEMBL847 ;
PDB ligand	OAQ (PDBe, RCSB PDB);
ECHA InfoCard	100.040.491
Chemical and physical data
Formula	C14H21N3O3
Molar mass	279.3
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES [O-][N+](=O)c1c(cc2c(c1)NC(CC2)CNC(C)C)CO;
	InChI InChI=1S/C14H21N3O3/c1-9(2)15-7-12-4-3-10-5-11(8-18)14(17(19)20)6-13(10)16-12/h5-6,9,12,15-16,18H,3-4,7-8H2,1-2H3 ; Key:XCGYUJZMCCFSRP-UHFFFAOYSA-N ;
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ଓକ୍ସାମ୍ନିକୁଇନ (ଇଂରାଜୀ ଭାଷାରେ Oxamniquine, ବିକ୍ରୟ ନାମ ଭାନସିଲ/Vansil ଏକ ଔଷଧ ଯାହା ସିସ୍ଟୋସୋମା ମାନସୋନି (Schistosoma mansoni) ଯୋଗୁ ହେଉଥିବା ସିସ୍ଟୋସୋମିଆସିସ ରୋଗ ନିମନ୍ତେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୧] କିନ୍ତୁ ଏହାଠାରୁ ପ୍ରାଜିକ୍ୱାଣ୍ଟେଲ ଅଧିକ ପସନ୍ଦ ଯୋଗ୍ୟ ଔଷଧ । ପାଟିରେ ଏହି ଔଷଧର ଏକ ଡୋଜ ମାତ୍ର ଦିଆଯାଏ । ^[୨]

ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାହୀନତା, ମୁଣ୍ଡବଥା, ଅଇ, ତରଳ ଝାଡ଼ା ଓ ଲାଲ ପରିସ୍ରା ଇତ୍ୟାଦି ଲକ୍ଷଣ ଦେଖାଯାଏ । ଗର୍ଭାବସ୍ଥାରେ ଏହା ଦେବାକୁ ମନାକରାଯାଏ । ଏପିଲେପ୍ସି/ ଅପସ୍ମାର ବାତ ରୋଗୀକୁ ଦେଲେ ବାତ (Seizures) ମାରିପାରେ ।^[୧] ପରଜୀବୀମାନଙ୍କୁ ପାରାଲିସିସ (paralyses) କରି ଏହା କାର୍ଯ୍ୟକାରୀ ହୁଏ ।^[୩] ଏହା ଆନ୍ଥେଲମିଣ୍ଟିକ (anthelmintic) ଶ୍ରେଣୀର ଏକ ଔଷଧ ।^[୪]

ସନ ୧୯୭୨ରେ ପ୍ରଥମେ ଓକ୍ସାମ୍ନିକୁଇନ ଔଷଧ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାରରେ ଲାଗିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ । ^[୬] ବ୍ୟବସାୟୀକ ଭିତ୍ତିରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ମିଳେନାହିଁ ।^[୪] ପ୍ରାଜିକ୍ୱାଣ୍ଟେଲ ଅପେକ୍ଷା ଏହା ଦାମିକା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 94. ISBN 9789241547659. Retrieved 8 December 2016.
↑ Griffiths, Jeffrey; Maguire, James H.; Heggenhougen, Kristian; Quah, Stella R. (2010). Public Health and Infectious Diseases (in ଇଂରାଜୀ). Elsevier. p. 351. ISBN 9780123815071.
↑ Cohen, Jonathan; Powderly, William G.; Opal, Steven M. (2016). Infectious Diseases (in ଇଂରାଜୀ) (4 ed.). Elsevier Health Sciences. p. 1371. ISBN 9780702063381.
↑ ^୪.୦ ^୪.୧ "Oxamniquine medical facts from Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.
↑ Jordan, Peter (1985). Schistosomiasis: The St Lucia Project (in ଇଂରାଜୀ). CUP Archive. p. 298. ISBN 9780521303125.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "International Strategies for Tropical Disease Treatments - Experiences with Praziquantel - EDM Research Series No. 026: Chapter 2: Bayer & E. Merck: Discovery and development of praziquantel*: Competing drugs for schistosomiasis treatment". apps.who.int. Retrieved 10 December 2016.

[WHO2008-1] ୧.୦ ^୧.୧ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 94. ISBN 9789241547659. Retrieved 8 December 2016.

[Grif2010-2] Griffiths, Jeffrey; Maguire, James H.; Heggenhougen, Kristian; Quah, Stella R. (2010). Public Health and Infectious Diseases (in ଇଂରାଜୀ). Elsevier. p. 351. ISBN 9780123815071.

[3] Cohen, Jonathan; Powderly, William G.; Opal, Steven M. (2016). Infectious Diseases (in ଇଂରାଜୀ) (4 ed.). Elsevier Health Sciences. p. 1371. ISBN 9780702063381.

[CONS2016-4] ୪.୦ ^୪.୧ "Oxamniquine medical facts from Drugs.com". www.drugs.com. Archived from the original on 20 December 2016. Retrieved 10 December 2016.

[5] Jordan, Peter (1985). Schistosomiasis: The St Lucia Project (in ଇଂରାଜୀ). CUP Archive. p. 298. ISBN 9780521303125.

[6] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[7] "International Strategies for Tropical Disease Treatments - Experiences with Praziquantel - EDM Research Series No. 026: Chapter 2: Bayer & E. Merck: Discovery and development of praziquantel*: Competing drugs for schistosomiasis treatment". apps.who.int. Retrieved 10 December 2016.

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