ମେଟ୍ରୋନିଡାଜୋଲ

ମେଟ୍ରୋନିଡାଜୋଲ
Clinical data
Pronunciation	/mɛtrəˈnaɪdəzoʊl/
Trade names	Flagyl,
AHFS/Drugs.com	monograph
Pregnancy; category	AU: B2 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	oral, topical, rectal, IV, vaginal
ATC code	A01AB17 (WHO) , D06BX01, G01AF01, J01XD01, P01AB01, QP51AA01 (WHO);
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Identifiers
	IUPAC name 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethanol;
CAS Number	443-48-1 ;
PubChem CID	4173;
DrugBank	DB00916 ;
ChemSpider	4029 ;
UNII	140QMO216E;
KEGG	D00409 ;
ChEBI	CHEBI:6909 ;
ChEMBL	CHEMBL137 ;
NIAID ChemDB	007953;
ECHA InfoCard	100.006.489
Chemical and physical data
Formula	C6H9N3O3
Molar mass	୧୭୧.୧୬ g·mol−1
Melting point	159 to 163 °C (318 to 325 °F)
	InChI InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3 ; Key:VAOCPAMSLUNLGC-UHFFFAOYSA-N ;
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ମେଟ୍ରୋନିଡାଜୋଲ (ଏମଏନ‌ଜେଡ) ଔଷଧ ବଜାରରେ ଫ୍ଲାଜିଲ ନାମରେ ବିକ୍ରୟ ହୁଏ; ଏହା ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଓ ଏକ‌କୋଷୀ ଜୀବ ସମ୍ବନ୍ଧୀୟ ଔଷଧ । ^[୩] ଏହାକୁ ଏକ‌କ ବା ଏକତ୍ର ଭାବେ ଅନ୍ୟ ଆଣ୍ଟିବାୟୋଟିକ ସ‌ହିତ ମିଶେଇ ପେଲଭିକ ପ୍ରଦାହ ରୋଗ, ଏଣ୍ଡୋକାର୍ଡ଼ାଇଟିସ ଓ ଜୀବାଣୁ ଭାଜିନୋସିସ ଚିକିତ୍ସା ନିମନ୍ତେ ବ୍ୟ‌ବ‌ହାର ହୁଏ । ଡ୍ରାକୁନ‌କୁଲିଆସିସ, ଜିଆଡିଆସିସ, ଟ୍ରାଇକୋମୋନିଆସିସ ଓ ଆମିବିଆସିସ ରୋଗମାନଙ୍କରେ କାର୍ଯ୍ୟକାରୀ ହୁଏ । ^[୩]ସାମାନ୍ୟ ଓ ମଧ୍ୟମ ଧରଣର କ୍ଲସ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ କୋଲାଇଟିସ ରୋଗର ପ୍ରଥମ ଘଟଣା ନିମନ୍ତେ ଏହା ପସନ୍ଦୀୟ ଔଷଧ । ^[୪] ଖାଇବା ନିମନ୍ତେ, କ୍ରିମ ଆକାରରେ ଓ ଶୀରା ମାଧମ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଏହି ଔଷଧ ମିଳେ । ^[୩]

ଅଇ, ଏକ ଧାତବ ସ୍ୱାଦ, ଅରୁଚି ଓ ମୁଣ୍ଡବଥା ଇତ୍ୟାଦି ଲକ୍ଷଣ ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଦର୍ଶାଏ । ବେଳେବେଳେ ବାତ (seizure) ଓ ଆଲର୍ଜି ହୁଏ । ଗର୍ଭର ପ୍ରଥମାବସ୍ଥାରେ ମେଟ୍ରୋନିଡାଜୋଲ ଦେବା ଉଚିତ ନୁହେଁ କିନ୍ତୁ ପରେ ଏହା ଅସୁବିଧା କରେ ନାହିଁ । ସ୍ତନ୍ୟପାନ କରାଉଥିଲେ ଏହା ବ୍ୟବ‌ହାର କରାଯାଏ ନାହିଁ । ^[୩]

ଫ୍ରାନ୍‌ସରେ ସନ ୧୯୬୦ରେ ମେଟ୍ରୋନିଡାଜୋଲ ପ୍ରଥମେ ବଜାରରେ ବିକ୍ରି ହେଲା । ^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ । ^[୬] ପୃଥିବୀର ଅଧିକାଂଶ ସ୍ଥାନରେ ଏହା ମିଳେ । ^[୭] ଏହା ଅତି ମୂଲ୍ୟବାନ ନୁହେଁ ଓ ଗୋଟିକୁ 0.0୧ରୁ 0.୧0 ଆମେରିକୀୟ ଡଲାର ମୂଲ୍ୟରେ ମିଳେ । ^[୮]^[୯] ଦଶ ଦିନର ଚିକିତ୍ସା ନିମନ୍ତେ ଏହାର ଖର୍ଚ୍ଚ ୨୬ ଅମେରିକୀୟ ଡଲାର । ^[୩]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Flagyl, Flagyl ER (metronidazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 April 2014.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Brayfield, A, ed. (14 January 2014). "Metronidazole". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 3 April 2014.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Metronidazole". The American Society of Health-System Pharmacists. Retrieved Jul 31,15. {{cite web}}: Check date values in: |accessdate= (help)
↑ Cohen, Stuart H.; Gerding, Dale N.; Johnson, Stuart; Kelly, Ciaran P.; Loo, Vivian G.; McDonald, L. Clifford; Pepin, Jacques; Wilcox, Mark H. (May 2010). "Clinical Practice Guidelines for Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)". Infection Control and Hospital Epidemiology. 31 (5): 431–455. doi:10.1086/651706. PMID 20307191.
↑ Corey, E.J. (2013). Drug discovery practices, processes, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 27. ISBN 9781118354469.
↑ "WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ Schmid G (28 July 2003). "Trichomoniasis treatment in women". Retrieved 1 August 2015.
↑ "Sources and Prices of Selected Medicines and Diagnostics for People Living with HIV/AIDS". World Health Organization. 2005. Retrieved 1 August 2015.
↑ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8 ed.). Elsevier Health Sciences. 2014. p. 2753. ISBN 9780323263733.

[MSR-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Flagyl, Flagyl ER (metronidazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 April 2014.

[MD-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ Brayfield, A, ed. (14 January 2014). "Metronidazole". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 3 April 2014.

[AHFS2015-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Metronidazole". The American Society of Health-System Pharmacists. Retrieved Jul 31,15. {{cite web}}: Check date values in: |accessdate= (help)

[4] Cohen, Stuart H.; Gerding, Dale N.; Johnson, Stuart; Kelly, Ciaran P.; Loo, Vivian G.; McDonald, L. Clifford; Pepin, Jacques; Wilcox, Mark H. (May 2010). "Clinical Practice Guidelines for Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)". Infection Control and Hospital Epidemiology. 31 (5): 431–455. doi:10.1086/651706. PMID 20307191.

[5] Corey, E.J. (2013). Drug discovery practices, processes, and perspectives. Hoboken, N.J.: John Wiley & Sons. p. 27. ISBN 9781118354469.

[WHOEssen-6] "WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[7] Schmid G (28 July 2003). "Trichomoniasis treatment in women". Retrieved 1 August 2015.

[8] "Sources and Prices of Selected Medicines and Diagnostics for People Living with HIV/AIDS". World Health Organization. 2005. Retrieved 1 August 2015.

[9] Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8 ed.). Elsevier Health Sciences. 2014. p. 2753. ISBN 9780323263733.

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