ଲୋଭାଷ୍ଟାଟିନ

ଲୋଭାଷ୍ଟାଟିନ
Clinical data
Trade names	Mevacor, Altocor, others
Synonyms	Monacolin K, Mevinolin
AHFS/Drugs.com	monograph
MedlinePlus	a688006
data	US DailyMed: Lovastatin;
Pregnancy; category	US: X (Contraindicated) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	<5%
Protein binding	>98%
Metabolism	Hepatic (CYP3A and CYP2C8 substrate)
Elimination half-life	2–5 hours
Excretion	Faeces (83%), urine (10%)
Identifiers
	IUPAC name (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate;
ECHA InfoCard	100.115.931
Chemical and physical data
Formula	C24H36O5
Molar mass	୪୦୪.୫୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O[C@@H]1[C@H]3C(=C/[C@H](C)C1)\C=C/[C@@H]([C@@H]3CC[C@H]2OC(=O)C[C@H](O)C2)C)[C@@H](C)CC;
	InChI InChI=1S/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14-,15-,16-,18+,19+,20-,21-,23-/m0/s1 ; Key:PCZOHLXUXFIOCF-BXMDZJJMSA-N ;
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ଲୋଭାଷ୍ଟାଟିନ,ଏକ ବ୍ୟବସାୟୀକ ନାମ ମେଭାକୋର ବ୍ରାଣ୍ଡ, ଏକ ପ୍ରକାର ଷ୍ଟାଟିନ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତ କୋଲେଷ୍ଟେରୋଲ ଚିକିତ୍ସା ପାଇଁ ଏବଂ ହୃଦରକ୍ତନାଳୀ ରୋଗର ଆଶଙ୍କା କମାଇବା ପାଇଁ ଦିଆଯାଏ | ^[୨] ଜୀବନଶୈଳୀ ପରିବର୍ତ୍ତନ ସହିତ ଏହାର ବ୍ୟବହାରକୁ ସୁପାରିଶ କରାଯାଏ | ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, କୋଷ୍ଠକାଠିନ୍ୟ, ମୁଣ୍ଡବିନ୍ଧା, ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା, ରାସ୍ ଏବଂ ଶୋଇବାରେ ଅସୁବିଧା ହୋଇପାରେ | ^[୨] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, , ରାବଡୋମାୟୋଲାଇସିସ, ଏବଂ ବୃକ୍‌କ ବିଫଳତା ହୋଇପାରେ | ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର କରିବା ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୪] ଏହା ଏଚଏମଜି-ସିଓଏ ରିଡକ୍ଟେଜ ଏଞ୍ଜାଇମକୁ ଅବରୋଧ କରି ଯକୃତଦ୍ୱାରା ସୃଷ୍ଟି ହେଉଥିବା କୋଲେଷ୍ଟେରୋଲ କ୍ଷମତାକୁ ହ୍ରାସ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୩]

ଲୋଭାଷ୍ଟାଟିନ ୧୯୭୯ ମସିହାର ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୮୭ ମସିହାରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୦.୦୫ ଡଲାର ଅଟେ। ^[୬] ୨୦୧୭ ମସିହାରେ ଏହାର ନଅ ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ହୋଇ ଯୁକ୍ତରାଷ୍ଟ୍ରର ୮୪ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା | ^[୭] ^[୮] ୨୦୦୯ରେ ଯୁକ୍ତରାଜ୍ୟରେ ଲୋଭାଷ୍ଟାଟିନ୍ ଉପଲବ୍ଧ ନଥିଲା | ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Neuvonen, PJ; Backman, JT; Niemi, M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Lovastatin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Lovastatin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ "Lovastatin Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Lovastatin - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.
↑ "Statins: updates to product safety information" (PDF). MHRA. November 2009. p. 2. Archived from the original (PDF) on 6 March 2019. Retrieved 3 March 2019.

[PK-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Neuvonen, PJ; Backman, JT; Niemi, M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955.

[AHFS2019-2] ୨.୦ ^୨.୧ ^୨.୨ "Lovastatin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[autogen1-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Lovastatin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[Preg2019-4] "Lovastatin Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.

[Fis2006-5] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 472. ISBN 9783527607495.

[NADAC2019-6] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[ref-7] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[ref1-8] "Lovastatin - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[9] "Statins: updates to product safety information" (PDF). MHRA. November 2009. p. 2. Archived from the original (PDF) on 6 March 2019. Retrieved 3 March 2019.

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