ଡାଇମରକାପ୍ରୋଲ

ଡାଇମରକାପ୍ରୋଲ
	Skeletal formula and ball and stick model of dimercaprol
Clinical data
Trade names	BAL in Oil
Synonyms	2,3-Dimercaptopropanol; British anti-Lewisite; 2,3-Dimercaptopropan-1-ol (no longer recommended); British antilewisite
AHFS/Drugs.com	monograph
data	US DailyMed: 4770;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	intramuscular
ATC code	V03AB09 (WHO) ;
Identifiers
CAS Number	59-52-9;
PubChem CID	3080;
DrugBank	DB06782;
ChemSpider	2971;
UNII	0CPP32S55X;
KEGG	D00167;
ChEMBL	CHEMBL1597;
ECHA InfoCard	100.000.394
Chemical and physical data
Formula	C3H8OS2
Molar mass	124.225 g mol−1
3D model (JSmol)	Interactive image;
Density	1.239 g cm−3 g/cm3
Boiling point	393 °C (739 °F) at 2.0 kPa
	SMILES OCC(S)CS;
	InChI InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2; ; Key:WQABCVAJNWAXTE-UHFFFAOYSA-N;

ଡାଇମରକାପ୍ରୋଲ (ଇଂରାଜୀ ଭାଷାରେ Dimercaprol ବା British anti-Lewisite/BAL) ଏକ ଔଷଧ ଯାହା ସିସା, ସୁନା (gold) ଓ ଆର୍ସେନିକ ବିଷକ୍ରିୟାର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୨] ବିଷକ୍ରିୟା (antimony), ଥାଲିଅମ (thallium) ଓ ବିସମଥ ବିଷକ୍ରିୟାରେ (bismuth poisoning) ବ୍ୟବ‌ହାର ହେଉଥିଲା ମଧ୍ୟ ଉପକାରୀତାର ବିଶେଷ ପ୍ରମାଣ ମିଳିନାହିଁ ।^[୨]^[୩] ଏହା ଇଞ୍ଜେକସନ ଆକାରରେ ମାଂସପେଶୀରେ (injection into a muscle) ଦିଆଯାଏ । ^[୨]

ଡାଇମରକାପ୍ରୋଲର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତଚାପ, ଇଞ୍ଜେକସନ ଦେବା ସ୍ଥାନରେ କଷ୍ଟ, ବାନ୍ତି ଓ ଜ୍ୱର ହୋଇପାରେ । ଚିନାବାଦାମ ଆଲର୍ଜି (peanut allergies) ଥିବା ଲୋକ‌କୁ ଏହା ଦିଆଯାଏନାହିଁ । ଗର୍ଭାବସ୍ଥାରେ ଶିଶୁ ପ୍ରତି ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ହୋଇନାହିଁ । ଡାଇମରକାପ୍ରୋଲ ଓଜନ‌ଦାର ଧାତୁ ସ‌ହିତ ଚିଲେସନ କରି (ବନ୍ଧିତ) (binding with heavy metals) ହୋଇ କାମ କରେ ।^[୨]

ଡାଇମରକାପ୍ରୋଲ ଦ୍ୱିତୀୟ ମହାଯୁଦ୍ଧ (World War II) ସମୟରେ ପ୍ରଥମେ ପ୍ରସ୍ତୁତ ହୋଇଥିଲା ।^[୪] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ କୋର୍ଷରେ ମୂଲ୍ୟ ୨୦୦ ଆମେରିକୀୟ ଡଲାରରୁ ଅଧିକ ।^[୬]

ଆଧାର

↑ Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 697. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. The prefixes 'mercapto' (–SH), and 'hydroseleno' or selenyl (–SeH), etc. are no longer recommended.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Dimercaprol". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 62. ISBN 9789241547659. Retrieved 8 December 2016.
↑ Greenwood, David (2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph (in ଇଂରାଜୀ). OUP Oxford. p. 281. ISBN 9780199534845.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 470. ISBN 9781284057560.

[iupac2013-1] Nomenclature of Organic Chemistry : IUPAC Recommendations and Preferred Names 2013 (Blue Book). Cambridge: The Royal Society of Chemistry. 2014. p. 697. doi:10.1039/9781849733069-FP001. ISBN 978-0-85404-182-4. The prefixes 'mercapto' (–SH), and 'hydroseleno' or selenyl (–SeH), etc. are no longer recommended.

[AHFS2016-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Dimercaprol". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[WHO2008-3] WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 62. ISBN 9789241547659. Retrieved 8 December 2016.

[4] Greenwood, David (2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph (in ଇଂରାଜୀ). OUP Oxford. p. 281. ISBN 9780199534845.

[WHO19th-5] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[Ric2015-6] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 470. ISBN 9781284057560.

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