ଡାନାଜୋଲ

ଡାନାଜୋଲ
Clinical data
Trade names	Danatrol, Danocrine, Danol, Danoval, others
Synonyms	WIN-17757; 2,3-Isoxazolethisterone; 2,3-Isoxazol-17α-ethynyltestosterone; 17α-Ethynyl-17β-hydroxyandrost-4-en-[2,3-d]isoxazole
AHFS/Drugs.com	monograph
MedlinePlus	a682599
Pregnancy; category	AU: D ; US: X (Contraindicated) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Saturable with dosage, higher with food intake
Protein binding	To albumin, SHBG, CBG
Metabolism	Liver (CYP3A4)
Metabolites	• 2-OHM-Ethisterone; • Ethisterone
Elimination half-life	Acute: 3–10 hours; Chronic: 24–26 hours
Excretion	Urine, feces
Identifiers
	IUPAC name (1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9-trien-17-ol;
ECHA InfoCard	100.037.503
Chemical and physical data
Formula	C22H27NO2
Molar mass	୩୩୭.୪୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5;
	InChI InChI=1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16-,17+,18+,20+,21+,22+/m1/s1 ; Key:POZRVZJJTULAOH-LHZXLZLDSA-N ;
(verify)

ଡାନାଜୋଲ, (ଇଂରାଜୀ ଭାଷାରେ Danazol) ଏକ ବିକ୍ରୟ ନାମ ଡାନୋକ୍ରାଇନ (Danocrine) ହେଉଛି ଏକ ଔଷଧ ଯାହା ଏଣ୍ଡୋମେଟ୍ରିଓସିସ, ଫାଇବ୍ରୋସିସ୍ଟିକ ସ୍ତନ ରୋଗ ଓ ହେରେଡିଟାରି ଆଞ୍ଜିଓଇଡିମା ଇତ୍ୟାଦି ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ଦିଆଯାଏ ।^[୯] ଏଣ୍ଡୋମେଟ୍ରିଓସିସ ରୋଗରେ ଡାନାଜୋଲ ଅପେକ୍ଷା ସ୍ୱଳ୍ପ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହେତୁ ଗୋନାଡ଼ୋଟ୍ରପିନ-ରିଲିଜିଙ୍ଗ ହରମୋନ ଆନାଲଗ (GnRH analogues) ସାଧାରଣତଃ ଦିଆଯାଏ । ଅସାମୟିକ ଯୌବନ କ୍ଷେତ୍ରରେ ଏହି ଔଷଧ ପ୍ରଭାବ‌ହୀନ ହୁଏ ।^[୧୦] ଏହା ପାଟିରେ ଦିଆଯାଏ ।

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଓଜନ ବୃଦ୍ଧି, ବ୍ରଣ, ଅସ୍ଥାନ କେଶ ବୃଦ୍ଧି ଓ ସ୍ୱର ମୋଟା ହୋଇପାରେ ।^[୧୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତ ଜମାଟ, ଯକୃତ ସମସ୍ୟା, ଆକ୍ରମଣାତ୍ମକ ଓ ଇଡିଓପାଥି ଇଣ୍ଟ୍ରାକ୍ରାନିଆଲ ହାଇପରଟେନସନ ହୋଇପାରେ ।^[୧୦] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବ‌ହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ । ଏହା ଯୌନ ସ୍ଟିରଏଡ ପ୍ରସ୍ତୁତି କମେଇଦିଏ, କିନ୍ତୁ ପ୍ରୋଜେଷ୍ଟେରନ ବା ଏଷ୍ଟ୍ରୋଜେନ କ୍ଷେତ୍ରରେ କିଛି ପରିବର୍ତ୍ତନ ହୁଏ ନାହିଁ ।

ଡାନାଜୋଲ ପ୍ରଥମେ ୧୯୬୩ ମସିହାରେ ପ୍ରସ୍ତୁତ କରାଯାଇଥିଲା ଓ ୧୯୭୧ ମସିହାରେ ଡାକ୍ତରୀ ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର ଆରମ୍ଭ ହୋଇଥିଲା ।^[୧୨]^[୧୩] ଏହା ଜେନେରିକ ନାମରେ ମିଳେ ।^[୧୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ମସିହାରେ ୨୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୬୦ଟି ବଟିକାର ମୂଲ୍ୟ ୧୧୫ ଡଲାର ଥିଲା । ଯୁକ୍ତରାଜ୍ୟରେ ଏହା ବିଶେଷ ଆଦେଶରେ ମିଳେ ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ Brayfield, A, ed. (30 October 2013). "Danazol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 1 April 2014.
↑ ^୨.୦ ^୨.୧ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1361–. ISBN 978-1-60913-345-0. Archived from the original on 10 January 2020. Retrieved 26 December 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Archive copy" (PDF). Archived (PDF) from the original on 2021-04-02. Retrieved 2020-12-26.{{cite web}}: CS1 maint: archived copy as title (link)
↑ J.P. Griffin; P.F. D'Arcy (17 November 1997). A Manual of Adverse Drug Interactions. Elsevier. pp. 194–. ISBN 978-0-08-052583-9. Archived from the original on 28 August 2021. Retrieved 26 December 2020.
↑ Eberhard Nieschlag; Hermann M. Behre; Susan Nieschlag (13 January 2010). Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. pp. 426–428. ISBN 978-3-540-78355-8.
↑ Eric J. Thomas; John Rock (6 December 2012). Modern Approaches to Endometriosis. Springer Science & Business Media. pp. 239–256. ISBN 978-94-011-3864-2. Archived from the original on 10 January 2020. Retrieved 26 December 2020.
↑ Florencio Zaragoza Dörwald (4 February 2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. pp. 485–. ISBN 978-3-527-64565-7. Archived from the original on 9 January 2020. Retrieved 26 December 2020.
↑ Robert J. Kurman (17 April 2013). Blaustein's Pathology of the Female Genital Tract. Springer Science & Business Media. pp. 390–. ISBN 978-1-4757-3889-6. Archived from the original on 10 January 2020. Retrieved 26 December 2020.
↑ ^୯.୦ ^୯.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 784. ISBN 978-0857114105.
↑ ^୧୦.୦ ^୧୦.୧ "Danazol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 May 2021. Retrieved 28 December 2021.
↑ Selak V, Farquhar C, Prentice A, Singla A (2007). Farquhar C (ed.). "Danazol for pelvic pain associated with endometriosis". Cochrane Database of Systematic Reviews (4): CD000068. doi:10.1002/14651858.CD000068.pub2. PMID 17943735.
↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 345–. ISBN 978-1-4757-2085-3.
↑ Howard W. Jones; John A. Rock (10 July 2015). Te Linde's Operative Gynecology. Wolters Kluwer Health. pp. 1327–1330. ISBN 978-1-4963-1521-2. Archived from the original on 10 January 2020. Retrieved 26 December 2020.
↑ "Danazol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 May 2016. Retrieved 28 December 2021.

[Martindale2013-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ Brayfield, A, ed. (30 October 2013). "Danazol". Martindale: The Complete Drug Reference. Pharmaceutical Press. Archived from the original on 28 August 2021. Retrieved 1 April 2014.

[LemkeWilliams2012-2] ୨.୦ ^୨.୧ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1361–. ISBN 978-1-60913-345-0. Archived from the original on 10 January 2020. Retrieved 26 December 2020.

[DanocrineLabel-3] ୩.୦ ^୩.୧ ^୩.୨ "Archive copy" (PDF). Archived (PDF) from the original on 2021-04-02. Retrieved 2020-12-26.{{cite web}}: CS1 maint: archived copy as title (link)

[GriffinD'Arcy1997-4] J.P. Griffin; P.F. D'Arcy (17 November 1997). A Manual of Adverse Drug Interactions. Elsevier. pp. 194–. ISBN 978-0-08-052583-9. Archived from the original on 28 August 2021. Retrieved 26 December 2020.

[Nie2010-5] Eberhard Nieschlag; Hermann M. Behre; Susan Nieschlag (13 January 2010). Andrology: Male Reproductive Health and Dysfunction. Springer Science & Business Media. pp. 426–428. ISBN 978-3-540-78355-8.

[ThomasRock2012-6] Eric J. Thomas; John Rock (6 December 2012). Modern Approaches to Endometriosis. Springer Science & Business Media. pp. 239–256. ISBN 978-94-011-3864-2. Archived from the original on 10 January 2020. Retrieved 26 December 2020.

[Dörwald2013-7] Florencio Zaragoza Dörwald (4 February 2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. pp. 485–. ISBN 978-3-527-64565-7. Archived from the original on 9 January 2020. Retrieved 26 December 2020.

[Kurman2013-8] Robert J. Kurman (17 April 2013). Blaustein's Pathology of the Female Genital Tract. Springer Science & Business Media. pp. 390–. ISBN 978-1-4757-3889-6. Archived from the original on 10 January 2020. Retrieved 26 December 2020.

[BNF81-9] ୯.୦ ^୯.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 784. ISBN 978-0857114105.

[AHFS2021-10] ୧୦.୦ ^୧୦.୧ "Danazol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 May 2021. Retrieved 28 December 2021.

[Far2007-11] Selak V, Farquhar C, Prentice A, Singla A (2007). Farquhar C (ed.). "Danazol for pelvic pain associated with endometriosis". Cochrane Database of Systematic Reviews (4): CD000068. doi:10.1002/14651858.CD000068.pub2. PMID 17943735.

[Elks2014-12] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 345–. ISBN 978-1-4757-2085-3.

[JonesRock2015-13] Howard W. Jones; John A. Rock (10 July 2015). Te Linde's Operative Gynecology. Wolters Kluwer Health. pp. 1327–1330. ISBN 978-1-4963-1521-2. Archived from the original on 10 January 2020. Retrieved 26 December 2020.

[GX2021-14] "Danazol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 6 May 2016. Retrieved 28 December 2021.

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