ବାଜେଡୋକ୍ସିଫେନ

ବାଜେଡୋକ୍ସିଫେନ
Clinical data
Pronunciation	ba" ze dox' i feen
Trade names	Conbriza, Viviant, others
Synonyms	Bazedoxifene acetate, TSE-424; WAY-140424; WAY-TSE-424
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Routes of; administration	By mouth
Legal status
Legal status	℞ (Prescription only);
Identifiers
	IUPAC name 1-[4-[2-(azepan-1-yl)ethoxy]benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol;
ECHA InfoCard	100.232.728
Chemical and physical data
Formula	C30H34N2O3
Molar mass	୪୭୦.୬୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Oc1ccc(cc1)c3c(c2cc(O)ccc2n3Cc5ccc(OCCN4CCCCCC4)cc5)C;
	InChI InChI=1S/C30H34N2O3/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31/h6-15,20,33-34H,2-5,16-19,21H2,1H3 ; Key:UCJGJABZCDBEDK-UHFFFAOYSA-N ;
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ବାଜେଡୋକ୍ସିଫେନ, ବେପାର ନାମ, କନବ୍ରିଜା ହେଉଛି ରୁତୁବନ୍ଦ ପରେ ହେଉଥିବା ଓଷ୍ଟିଓପୋରୋସିସ୍ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ । ^[୨] ଏହା ମେରୁଦଣ୍ଡର ଭାଙ୍ଗିବା ଆଶଙ୍କା ହ୍ରାସ କରିଥାଏ କିନ୍ତୁ ହିପ ଭଙ୍ଗା ନୁହେଁ । ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗରମ ଫ୍ଲସ, ମାଂସପେଶୀ ସ୍ପାଜ୍ମ ଏବଂ ଗୋଡର ଫୁଲା ହୋଇପାରେ । ^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରକ୍ତ ଜମାଟ ବାନ୍ଧିପାରେ । ^[୨] ଗର୍ଭାବସ୍ଥାରେ ଏହାକୁ ବ୍ୟବହାର କରିବା ଉଚିତ୍ ନୁହେଁ।| ^[୨] ଏହା ଏକ ସିଲେକ୍ଟିଭ ଇଷ୍ଟ୍ରୋଜେନ୍ ରିସେପ୍ଟର ମଡ୍ୟୁଲେଟର (SERM) । ^[୨]

୨୦୦୯ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ବାଜେଡୋକ୍ସିଫେନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ ମିଶ୍ରଣ ବାଜେଡୋକ୍ସିଫେନ/କଞ୍ଜରଗେଟଡ ଏଷ୍ଟ୍ରୋଜେନ ଆକାରରେ ମିଳେ ।^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Selective Estrogen Receptor Modulators". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 8 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Conbriza". Archived from the original on 6 January 2021. Retrieved 8 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ "Selective Estrogen Receptor Modulators". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 January 2022. Retrieved 8 January 2022.

[EPAR2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Conbriza". Archived from the original on 6 January 2021. Retrieved 8 January 2022.

[୨]

[୧]

Clinical data


Pronunciation	ba" ze dox' i feen^[୧]
Trade names	Conbriza, Viviant, others
Synonyms	Bazedoxifene acetate, TSE-424; WAY-140424; WAY-TSE-424
AHFS/Drugs.com	monograph
data	EU EMA: yes
Routes of administration	By mouth
Legal status
Legal status	℞ (Prescription only)
Identifiers
IUPAC name 1-[4-[2-(azepan-1-yl)ethoxy]benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol
ECHA InfoCard	100.232.728
Chemical and physical data
Formula	C₃₀H₃₄N₂O₃
Molar mass	୪୭୦.୬୧ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc1ccc(cc1)c3c(c2cc(O)ccc2n3Cc5ccc(OCCN4CCCCCC4)cc5)C
InChI InChI=1S/C30H34N2O3/c1-22-28-20-26(34)12-15-29(28)32(30(22)24-8-10-25(33)11-9-24)21-23-6-13-27(14-7-23)35-19-18-31-16-4-2-3-5-17-31/h6-15,20,33-34H,2-5,16-19,21H2,1H3^Y Key:UCJGJABZCDBEDK-UHFFFAOYSA-N^Y
(verify)