ସେରିଟିନିବ

ସେରିଟିନିବ
Clinical data
Pronunciation	Ceritinib: /səˈrɪtɪnɪb/ sə-RIT-i-nib; Zykadia: /zaɪˈkeɪdiːə/ zy-KAY-dee-ə
Trade names	Zykadia, Spexib, others
Synonyms	LDK378
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Pregnancy; category	US: D (Evidence of risk) ; ;
Routes of; administration	By mouth (capsules)
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	Not determined
Protein binding	97%
Metabolism	CYP3A
Elimination half-life	41 hours
Excretion	Feces (92.3%), urine (1.3%)
Identifiers
	IUPAC name 5-Chloro-N2-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N4-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine;
ECHA InfoCard	100.241.919
Chemical and physical data
Formula	C28H36ClN5O3S
Molar mass	୫୫୮.୧୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl;
	InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34); Key:VERWOWGGCGHDQE-UHFFFAOYSA-N;

ସେରିଟିନିବ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ Zykadia, ଏକ ଔଷଧ ଯାହା ଅଣ-ଛୋଟ ଜୀବକୋଷ ଫୁସଫୁସ କର୍କଟର (NSCLC) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୨] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଉନ୍ନତ ରୋଗ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ଯାହା ଆନାପ୍ଲାଷ୍ଟିକ୍ ଲିମ୍ଫୋମା କାଇନେଜ (ALK) ପଜିଟିଭ୍ ଅଟେ | ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ଅଇ, ଥକାପଣ, ଯକୃତ ସମସ୍ୟା, ଓଜନ ହ୍ରାସ, ରାସ, ବୃକ୍‌କ ସମସ୍ୟା ଏବଂ ନିମ୍ନ ଲୋହିତ ରକ୍ତ କଣିକା ହୋଇପାରେ । ^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା, ନିମୋନିଆ, ଲଙ୍ଗ କ୍ୟୁଟି ସିଣ୍ଡ୍ରୋମ ଏବଂ ଅଗ୍ନାଶୟ ପ୍ରଦାହ ହୋଇପାରେ। ^[୨] ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ ।^[୩] ଏହା ଏକ ଟାଇରୋସିନ୍ କାଇନେଜ ଇନହିବିଟର, ବିଶେଷ ଭାବରେ ଏକ ଏଏଲକେ (ALK) ପ୍ରତିବନ୍ଧକ । ^[୨] ^[୪]

୨୦୧୪ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୧୫ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ସେରିଟିନିବ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ସପ୍ତାହର ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୮୦୦ ପାଉଣ୍ଡ ହୁଏ । ^[୪] ଯୁକ୍ରରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ଖର୍ଚ୍ଚ ୧୦,୪୦୦ ଡଲାର ।^[୫]

ଆଧାର

↑ "Zykadia (ceritinib) Capsules, for Oral Use. Full Prescribing Information" (PDF). Novartis Pharmaceuticals Corporation. Archived (PDF) from the original on 28 April 2019. Retrieved 14 February 2017.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Zykadia". Archived from the original on 13 October 2021. Retrieved 3 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ZYKADIA- ceritinib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 24 March 2021. Retrieved 3 January 2022.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1018. ISBN 978-0857114105.
↑ "Ceritinib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 January 2022.

[PI-1] "Zykadia (ceritinib) Capsules, for Oral Use. Full Prescribing Information" (PDF). Novartis Pharmaceuticals Corporation. Archived (PDF) from the original on 28 April 2019. Retrieved 14 February 2017.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Zykadia". Archived from the original on 13 October 2021. Retrieved 3 January 2022.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ "DailyMed - ZYKADIA- ceritinib tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 24 March 2021. Retrieved 3 January 2022.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1018. ISBN 978-0857114105.

[5] "Ceritinib Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 3 January 2022.

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[୩]

[୧]

[୪]

[୫]

Clinical data

Pronunciation	Ceritinib: /səˈrɪtɪnɪb/ sə-RIT-i-nib Zykadia: /zaɪˈkeɪdiːə/ zy-KAY-dee-ə
Trade names	Zykadia, Spexib, others
Synonyms	LDK378
AHFS/Drugs.com	monograph
data	EU EMA: yes
Pregnancy category	US: D (Evidence of risk)
Routes of administration	By mouth (capsules)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	Not determined
Protein binding	97%
Metabolism	CYP3A
Elimination half-life	41 hours
Excretion	Feces (92.3%), urine (1.3%)^[୧]
Identifiers
IUPAC name 5-Chloro-N²-{5-methyl-4-(piperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N⁴-[2-(propane-2-sulfonyl)phenyl]pyrimidine-2,4-diamine
ECHA InfoCard	100.241.919
Chemical and physical data
Formula	C₂₈H₃₆ClN₅O₃S
Molar mass	୫୫୮.୧୪ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=CC(=C(C=C1C2CCNCC2)OC(C)C)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)C(C)C)Cl
InChI InChI=1S/C28H36ClN5O3S/c1-17(2)37-25-15-21(20-10-12-30-13-11-20)19(5)14-24(25)33-28-31-16-22(29)27(34-28)32-23-8-6-7-9-26(23)38(35,36)18(3)4/h6-9,14-18,20,30H,10-13H2,1-5H3,(H2,31,32,33,34) Key:VERWOWGGCGHDQE-UHFFFAOYSA-N