ରିଲପିଭିରିନ

ରିଲପିଭିରିନ
Clinical data
Trade names	Edurant, Rekambys
Synonyms	TMC278
AHFS/Drugs.com	monograph
MedlinePlus	a611037
data	EU EMA: yes; US DailyMed: Rilpivirine;
Pregnancy; category	AU: B1 ; ;
Routes of; administration	By mouth, intramuscular
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	99.7%
Metabolism	CYP3A4
Elimination half-life	tablets: 45 hours; injection: 13–28 weeks
Excretion	85% via faeces, 6% via urine
Identifiers
	IUPAC name 4-{[4-({4-[(E)-2-cyanovinyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile;
ECHA InfoCard	100.224.394
Chemical and physical data
Formula	C22H18N6
Molar mass	୩୬୬.୪୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1cc(cc(c1Nc2ccnc(n2)Nc3ccc(cc3)C#N)C)/C=C/C#N;
	InChI InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+ ; Key:YIBOMRUWOWDFLG-ONEGZZNKSA-N ;
(verify)

ରିଲପିଭିରିନ (ଇଂରାଜୀ ଭାଷାରେ Rilpivirine), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଇଡୁରାଣ୍ଟ ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଏଚ୍.ଆଇ.ଭି. ରୋଗର ଚିକିତ୍ସା ଓ ପ୍ରତିଷେଧ ନିମନ୍ତେ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଏଚ୍‌ଆଇଭି-୧ ପାଇଁ ଅନ୍ୟ ଭୂତାଣୁରୋଧୀ ଔଷଦ ସହିତ ମିଳିତ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଶୋଇବାରେ ଅସୁବିଧା, ମୁଣ୍ଡ ବୁଲାଇବା, ଅଇ, ଅସ୍ୱାଭାବିକ ଲିପିଡ ସ୍ତର ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।^[୬] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଇଓସିନୋଫିଲିଆ ଏବଂ ସଶରୀର ଲକ୍ଷଣ (DRESS), ଅବସାଦ ଏବଂ ଔଷଧ ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ନିରାପଦ ଦେଖାଯାଏ, କିନ୍ତୁ ଯେପରି ଭଲ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୮] ଏହା ଏକ ଅଣ-ନ୍ୟୁକ୍ଲିଓସାଇଡ୍ ରିଭର୍ସ ଟ୍ରାନ୍ସକ୍ରିପଟେଜ୍ ଇନହିବିଟର (NNRTI) ଯାହା ଏନଜାଇମ୍ ରିଭର୍ସ ଟ୍ରାନ୍ସକ୍ରିପଟେଜକୁ ଅବରୋଧ କରିଥାଏ | ^[୬]

୨୦୧୧ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ରିଲପିଭିରିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏକ ମାସରେ ୨୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧୨୦୦ ଡଲାର ଅଟେ ।^[୯]

ଆଧାର

↑ "Edurant EPAR". European Medicines Agency (EMA). Archived from the original on 7 January 2021. Retrieved 4 January 2021.
↑ "Rekambys EPAR". European Medicines Agency (EMA). 13 October 2020. Archived from the original on 8 January 2021. Retrieved 4 January 2021.
↑ "Edurant 25 mg tablets - Summary of Product Characteristics (SmPC)". (emc). 21 January 2020. Archived from the original on 7 January 2021. Retrieved 4 January 2021.
↑ "Edurant- rilpivirine hydrochloride tablet, film coated". DailyMed. Archived from the original on 28 October 2020. Retrieved 4 January 2021.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Rilpivirine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 17 October 2021.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Rilpivirine". Archived from the original on 7 January 2021. Retrieved 17 October 2021.
↑ ^୭.୦ ^୭.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 683. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Rilpivirine (Edurant) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2020. Retrieved 17 October 2021.
↑ "Edurant Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 30 July 2015. Retrieved 17 October 2021.

[1] "Edurant EPAR". European Medicines Agency (EMA). Archived from the original on 7 January 2021. Retrieved 4 January 2021.

[Rekambys_EPAR-2] "Rekambys EPAR". European Medicines Agency (EMA). 13 October 2020. Archived from the original on 8 January 2021. Retrieved 4 January 2021.

[3] "Edurant 25 mg tablets - Summary of Product Characteristics (SmPC)". (emc). 21 January 2020. Archived from the original on 7 January 2021. Retrieved 4 January 2021.

[4] "Edurant- rilpivirine hydrochloride tablet, film coated". DailyMed. Archived from the original on 28 October 2020. Retrieved 4 January 2021.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ "Rilpivirine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 17 October 2021.

[EPAR2021-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Rilpivirine". Archived from the original on 7 January 2021. Retrieved 17 October 2021.

[BNF80-7] ୭.୦ ^୭.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 683. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[8] "Rilpivirine (Edurant) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2020. Retrieved 17 October 2021.

[9] "Edurant Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 30 July 2015. Retrieved 17 October 2021.

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