ରାଭୁଲିଜୁମାବ

ରାଭୁଲିଜୁମାବ
Monoclonal antibody
Type	Whole antibody
Source	Humanized (from mouse)
Target	Complement component 5
Clinical data
Pronunciation	rav" ue liz' ue mab
Trade names	Ultomiris
Synonyms	ALXN1210, ravulizumab-cwvz
AHFS/Drugs.com	monograph
MedlinePlus	a619014
data	EU EMA: yes; US DailyMed: Ravulizumab;
Pregnancy; category	AU: B2 ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Metabolism	various proteases
Chemical and physical data
Formula	C6430H9888N1696O2028S48
Molar mass	୧,୪୪,୯୩୮.୫୬ g·mol−1

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ରାଭୁଲିଜୁମାବ (ଇଂରାଜୀ ଭାଷାରେ Ravulizumab, ଏକ ବେପାର ନାମ ଅଲ୍ଟୋମିରିସ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ପାରୋକ୍ସିସମାଲ୍ ନୋକଟରନାଲ ହେମୋଗ୍ଲୋବିନୁରିଆ (PNH) ଏବଂ ଆଟିପିକାଲ୍ ହେମୋଲାଇଟିକ୍ ୟୁରେମିକ ସିଣ୍ଡ୍ରୋମର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ଏକ ଶିରାରେ ଧୀରେ ଧୀରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉର୍ଦ୍ଧ୍ୱ ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ, ତରଳ ଝାଡ଼ା, ଜ୍ୱର, ଅଇ, ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୧] ^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମେନିଙ୍ଗୋକୋକାଲ୍ ସଂକ୍ରମଣ ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ କୌଣସି ସ୍ପଷ୍ଟ କ୍ଷତି ହୋଇନଥିବାବେଳେ ଏହିପରି ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୬] ଏହା ଏକ ମୋନୋକ୍ଲୋନାଲ ଆଣ୍ଟିବଡି ଯାହା ସଂପୃକ୍ତ ଉପାଦାନ ୫ (complement component 5/ C5)ର କାର୍ଯ୍ୟକଳାପ ସ‌ହିତ ସଂଯୁକ୍ତ ହେ ଅବରୋଧ କରେ ।^[୧]

୨୦୧୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୯ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ରାଭୁଲିଜୁମାବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୧୯ ସୁଦ୍ଧା ବର୍ଷକୁ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୪୬୦,୦୦୦ ଡଲାର ଅଟେ ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Ultomiris EPAR". European Medicines Agency (EMA). 24 April 2019. Archived from the original on 8 May 2020. Retrieved 1 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Ultomiris 300 mg concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 18 October 2020. Retrieved 12 October 2020.
↑ "Ultomiris- ravulizumab solution, concentrate". DailyMed. 20 March 2020. Archived from the original on 23 September 2020. Retrieved 1 May 2020.
↑ ^୪.୦ ^୪.୧ "DailyMed - ULTOMIRIS- ravulizumab solution, concentrate". dailymed.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 16 October 2021.
↑ ^୫.୦ ^୫.୧ "Ravulizumab-cwvz Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 October 2021.
↑ "Ravulizumab (Ultomiris) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 16 October 2021.
↑ Stern, RM; Connell, NT (2019). "Ravulizumab: a novel C5 inhibitor for the treatment of paroxysmal nocturnal hemoglobinuria". Therapeutic advances in hematology. 10: 2040620719874728. doi:10.1177/2040620719874728. PMID 31534662.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Ultomiris EPAR". European Medicines Agency (EMA). 24 April 2019. Archived from the original on 8 May 2020. Retrieved 1 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[2] "Ultomiris 300 mg concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). Archived from the original on 18 October 2020. Retrieved 12 October 2020.

[Ultomiris_FDA_label-3] "Ultomiris- ravulizumab solution, concentrate". DailyMed. 20 March 2020. Archived from the original on 23 September 2020. Retrieved 1 May 2020.

[PI2021-4] ୪.୦ ^୪.୧ "DailyMed - ULTOMIRIS- ravulizumab solution, concentrate". dailymed.nlm.nih.gov. Archived from the original on 23 September 2020. Retrieved 16 October 2021.

[AHFS2021-5] ୫.୦ ^୫.୧ "Ravulizumab-cwvz Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 October 2021.

[6] "Ravulizumab (Ultomiris) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 16 October 2021.

[7] Stern, RM; Connell, NT (2019). "Ravulizumab: a novel C5 inhibitor for the treatment of paroxysmal nocturnal hemoglobinuria". Therapeutic advances in hematology. 10: 2040620719874728. doi:10.1177/2040620719874728. PMID 31534662.

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