ଭାଙ୍କୋମାଇସିନ

Vancomycin INN
Clinical data
Pronunciation	/væŋk[invalid input: 'ɵ']ˈmaɪs[invalid input: 'ɨ']n/
Trade names	Vancocin
AHFS/Drugs.com	monograph
MedlinePlus	a604038
data	US FDA: Vancocin;
Pregnancy; category	AU: B2 ; B (PO) / C (IV)(US);
Routes of; administration	IV, oral
ATC code	A07AA09 (WHO) J01XA01;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Negligible (oral)
Metabolism	Excreted unchanged
Elimination half-life	4–11 hours (adults); 6-10 days (adults, impaired renal function)
Excretion	Renal
Identifiers
	IUPAC name (1S,2R,18R,19R,22S,25R,28R,40S)- 48- {[(2S,3R,4S,5S,6R)- 3- {[(2S,4S,5S,6S)- 4- amino- 5- hydroxy- 4,6- dimethyloxan- 2- yl]oxy}- 4,5- dihydroxy- 6- (hydroxymethyl)oxan- 2- yl]oxy}- 22- (carbamoylmethyl)- 5,15- dichloro- 2,18,32,35,37- pentahydroxy- 19- [(2R)- 4- methyl- 2- (methylamino)pentanamido]- 20,23,26,42,44- pentaoxo- 7,13- dioxa- 21,24,27,41,43- pentaazaoctacyclo[26.14.2.23,6.214,17.18,12.129,33.010,25.034,39]pentaconta- 3,5,8(48),9,11,14,16,29(45),30,32,34,36,38,46,49- pentadecaene- 40- carboxylic acid;
CAS Number	1404-90-6 ;
PubChem CID	14969;
DrugBank	DB00512 ;
ChemSpider	14253 ;
UNII	6Q205EH1VU;
KEGG	D00212 ;
ChEBI	CHEBI:28001 ;
ChEMBL	CHEMBL262777 ;
ECHA InfoCard	100.014.338
Chemical and physical data
Formula	C66H75Cl2N9O24
Molar mass	1449.3 g.mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2Oc3c4cc5cc3Oc6ccc(cc6Cl)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7c8ccc(c(c8)-c9c(cc(cc9O)O)[C@H](NC(=O)[C@H]([C@@H](c1ccc(c(c1)Cl)O4)O)NC7=O)C(=O)O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)CO)O)O)(C)N)O;
	InChI InChI=1S/C66H75Cl2N9O24/c1-23(2)12-34(71-5)58(88)76-49-51(83)26-7-10-38(32(67)14-26)97-40-16-28-17-41(55(40)101-65-56(54(86)53(85)42(22-78)99-65)100-44-21-66(4,70)57(87)24(3)96-44)98-39-11-8-27(15-33(39)68)52(84)50-63(93)75-48(64(94)95)31-18-29(79)19-37(81)45(31)30-13-25(6-9-36(30)80)46(60(90)77-50)74-61(91)47(28)73-59(89)35(20-43(69)82)72-62(49)92/h6-11,13-19,23-24,34-35,42,44,46-54,56-57,65,71,78-81,83-87H,12,20-22,70H2,1-5H3,(H2,69,82)(H,72,92)(H,73,89)(H,74,91)(H,75,93)(H,76,88)(H,77,90)(H,94,95)/t24-,34+,35-,42+,44-,46+,47+,48-,49+,50-,51+,52+,53+,54-,56+,57+,65-,66-/m0/s1 ; Key:MYPYJXKWCTUITO-LYRMYLQWSA-N ;
(verify)

ଭାଙ୍କୋମାଇସିନ ଏକ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ଅନେକ ପ୍ରକାରର ଜୀବାଣୁ ସଂକ୍ରମଣର ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ । ^[୧] ଶିରା ଇଞ୍ଜେକସନ ଆକାରରେ ପ୍ରଥମ ଧାଡ଼ି ଚିକିତ୍ସା ଭାବରେରେ ଏହା ଦିଆଯାଉଥିବା ଜଟିଳ ହୋଇଥିବା ରୋଗମାନଙ୍କ ନାମ ଚର୍ମ ସଂକ୍ରମଣ, ରକ୍ତ ସଂକ୍ରମଣ, ଏଣ୍ଡୋକାର୍ଡ଼ାଇଟିସ, ଅସ୍ଥି-ଗଣ୍ଠି ସଂକ୍ରମଣ ଓ ମେଥିସିଲିନ ପ୍ରତିରୋଧିତ ସ୍ଟାଫିଲୋକୋକସ ଅରିଅସ ସଂକ୍ରମଣ ରୋଗ ସମୂହ ।^[୨] ରକ୍ତ ପରୀକ୍ଷା କରି ଏହାର ସଠିକ ଡୋଜ ଦିଆଯାଇପାରେ ।^[୩] ଏହି ଔଷଧ ସାଂଘାତିକ କ୍ଲସ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ କୋଲାଇଟିସ ରୋଗରେ ପାଟିରେ ଦିଆଯାଇପାରେ । ପାଟିରେ ଦିଆଯାଉଥିବା ଔଷଧ ଭଲରୂପେ ଅବଶୋଷିତ ହୋଇପାରେ ନାହିଁ । ^[୧]

ଇଞ୍ଜେକସନ ଦିଆଯାଇଥିବା ସ୍ଥାନରେ କଷ୍ଟ ଓ ଆଲର୍ଜି ଏହାର ମୂଖ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା । ବେଳେ ବେଳେ ଶ୍ରବଣ ଅସୁବିଧା, ନିମ୍ନ ରକ୍ତଚାପ ଓ ଅସ୍ଥିମଜ୍ଜା ଦମନ ଭଳି ପ୍ରତିକ୍ରିୟା ହୁଏ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ଏହାର ନିରାପତ୍ତା ସ୍ପଷ୍ଟ ନ ହେଲେ ମଧ୍ୟ କୌଣସି କ୍ଷତି ହେବାର ପ୍ରମାଣ ମିଳିନାହିଁ, ^[୧]^[୪] ଓ ସ୍ତନ୍ୟପାନରେ ଏହା ନିରାପଦ ଥିବା ସମ୍ଭାବନା ଅଧିକ । ^[୫] ଏହା ଏକ ପ୍ରକାର ଗ୍ଲାଇକୋପେପ୍‌ଟାଇଡ ଆଣ୍ଟିବାୟୋଟିକ ଯାହା ଜୀବକୋଷ କାନ୍ଥ ତିଆରିକୁ ପ୍ରତିହତ କରେ ।^[୧]

ସନ ୧୯୫୪ରେ ପ୍ରଥମେ ଭାଙ୍କୋମାଇସିନ ବିକ୍ରି ଆରମ୍ଭ ହୋଇଥିଲା । ^[୬] > ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୭] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ।^[୩] ଶୀରା ଇଞ୍ଜେକସନର ଡୋଜପିଛା ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୧.୭୦ରୁ ୬.୦୦ ଆମେରିକୀୟ ଡଲାର ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଶୀରାଇଞ୍ଜେକସନ ଅପେକ୍ଷା ପାଟିରେ ଦିଆଯିବା ପିଲ ଅଧିକ ଦାମ ପଡ଼େ । ^[୧] ଖର୍ଚ୍ଚ କମେଇବା ପାଇଁ କ୍ଲସ୍ଟ୍ରିଡିଅମ ଡିଫିସିଲ କୋଲାଇଟିସରେ ଇଞ୍ଜେକସନ ଔଷଧକୁ ପାଟିରେ ଦିଆଯାଇପାରେ । ^[୯] ମାଟିରେ ଥିବା ଆମିକୋଲାଟପସିସ ଓରିଏଣ୍ଟାଲିସ ଜୀବାଣୁ ଭାଙ୍କୋମାଇସିନ ତିଆରି କରେ । ^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Vancocin". The American Society of Health-System Pharmacists. Retrieved Sep 4, 2015.
↑ Liu, C; Bayer, A; Cosgrove, SE; Daum, RS; Fridkin, SK; Gorwitz, RJ; Kaplan, SL; Karchmer, AW; Levine, DP; Murray, BE; J Rybak, M; Talan, DA; Chambers, HF (1 February 2011). "Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 52 (3): 285–92. doi:10.1093/cid/cir034. PMID 21217178.
↑ ^୩.୦ ^୩.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 91. ISBN 9781284057560.
↑ "Prescribing medicines in pregnancy database". Australian Government. Sep 2015. Retrieved Sep 2015. {{cite web}}: Check date values in: |accessdate= (help)
↑ "Vancomycin use while Breastfeeding". Retrieved 5 September 2015.
↑ Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Vancomycin". International Drug Price Indicator Guide. Retrieved 5 September 2015.^{[permanent dead link]}
↑ Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8 ed.). Elsevier Health Sciences. 2014. p. 2753. ISBN 9780323263733.

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Vancocin". The American Society of Health-System Pharmacists. Retrieved Sep 4, 2015.

[2] Liu, C; Bayer, A; Cosgrove, SE; Daum, RS; Fridkin, SK; Gorwitz, RJ; Kaplan, SL; Karchmer, AW; Levine, DP; Murray, BE; J Rybak, M; Talan, DA; Chambers, HF (1 February 2011). "Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary". Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 52 (3): 285–92. doi:10.1093/cid/cir034. PMID 21217178.

[Ric2015-3] ୩.୦ ^୩.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 91. ISBN 9781284057560.

[4] "Prescribing medicines in pregnancy database". Australian Government. Sep 2015. Retrieved Sep 2015. {{cite web}}: Check date values in: |accessdate= (help)

[5] "Vancomycin use while Breastfeeding". Retrieved 5 September 2015.

[6] Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621.

[7] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[ERC2015-8] "Vancomycin". International Drug Price Indicator Guide. Retrieved 5 September 2015.^{[permanent dead link]}

[Man2014-9] Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (8 ed.). Elsevier Health Sciences. 2014. p. 2753. ISBN 9780323263733.

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