ବ୍ରୋମୋକ୍ରିପ୍ଟାଇନ

ବ୍ରୋମୋକ୍ରିପ୍ଟାଇନ
Clinical data
Trade names	Parlodel, Cycloset, others
Synonyms	Bromocriptine mesilate, bromocriptine mesylate, 2-Bromoergocriptine; CB-154
AHFS/Drugs.com	monograph
MedlinePlus	a682079
Pregnancy; category	AU: A ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	28% of oral dose
Metabolism	Extensively liver-mediated
Elimination half-life	12–14 hours
Excretion	85% bile (feces), 2.5–5.5% urine
Identifiers
	IUPAC name (5′α)-2-Bromo-12′-hydroxy-5′-(2-methylpropyl)-3′,6′,18-trioxo-2′-(propan-2-yl)ergotaman;
ECHA InfoCard	100.042.829
Chemical and physical data
Formula	C32H40BrN5O5
Molar mass	୬୫୪.୬୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES BrC1=C(C[C@H]2N(C)C3)C4=C(C=CC=C4C2=C[C@H]3C(N[C@]5(C(C)C)O[C@@]6(N([C@@H](CC(C)C)C(N7CCC[C@H]76)=O)C5=O)O)=O)N1;
	InChI InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1 ; Key:OZVBMTJYIDMWIL-AYFBDAFISA-N ;
(verify)

ବ୍ରୋମୋକ୍ରିପ୍ଟାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ପାର୍ଲୋଡେଲ୍, ଏକ ଔଷଧ ଯାହା ପ୍ରୋଲାକ୍ଟିନୋମା, ପାର୍କିନ୍‌ସନ୍ ରୋଗ, ଆକ୍ରୋମାଗାଲି, ନ୍ୟୁରୋଲେପ୍ଟିକ୍ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ ରୋଗମାନଙ୍କ ଚିକିତ୍ସା ଏବଂ ଦୁଗ୍ଧ ଉତ୍ପାଦନ ବନ୍ଦ କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୨] ^[୩] ଏହା ଟାଇପ୍-୨ ମଧୁମେହରେ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ମୁଣ୍ଡବିନ୍ଧା, ଥକାପଣ, ମୁଣ୍ଡ ବୁଲାଇବା, କୋଷ୍ଠକାଠିନ୍ୟ ଏବଂ ନିଦ୍ରା ଅନ୍ତର୍ଭୁକ୍ତ । ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ଏବଂ ପେରିକାର୍ଡିଆଲ୍ ଇଫ୍ୟୁଜନ୍, ଦ୍ୱନ୍ଦ୍ୱ ହୋଇପାରେ । ^[୬] ଶିଶୁର କୌଣସି ଅନିଷ୍ଟ ନକରି ଏହାକୁ ଅନେକ ଗର୍ଭବତୀ ମହିଳା ବ୍ୟବହାର କରିଛନ୍ତି। ^[୭] ଏହା ଡୋପାମାଇନ୍ ରିସେପ୍ଟରଗୁଡ଼ିକୁ ସକ୍ରିୟ କରି ଓ ପ୍ରୋଲାକ୍ଟିନ୍ ନିଷ୍କାସନ ହ୍ରାସ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ । ^[୨]

ବ୍ରୋମୋକ୍ରିପ୍ଟାଇନ୍ ୧୧୯୬୮ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୭୫ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୮] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ମିଗ୍ରାର ୩୦ଟି ବଟିକାର ୨୦୨୧ ସୁଦ୍ଧା ମୂଲ୍ୟ ୭୫ ପାଉଣ୍ଡ । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ୩୦ ଡଲାର । ^[୯]

ଆଧାର

↑ "Bromocriptine international brand names". Drugs.com. Archived from the original on 6 August 2017. Retrieved 13 July 2017.
↑ ^୨.୦ ^୨.୧ ^୨.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.
↑ ^୩.୦ ^୩.୧ "Bromocriptine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 12 January 2022.
↑ "DailyMed - CYCLOSET- bromocriptine mesylate tablet". dailymed.nlm.nih.gov. Archived from the original on 29 March 2021. Retrieved 12 January 2022.
↑ ^୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.
↑ "Bromocriptine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 12 January 2022.
↑ "Bromocriptine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 12 January 2022.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 533. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-06-30.
↑ "Bromocriptine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 12 January 2022.

[brands-1] "Bromocriptine international brand names". Drugs.com. Archived from the original on 6 August 2017. Retrieved 13 July 2017.

[BNF81-2] ୨.୦ ^୨.୧ ^୨.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.

[AHFS2022-3] ୩.୦ ^୩.୧ "Bromocriptine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 12 January 2022.

[DM2022-4] "DailyMed - CYCLOSET- bromocriptine mesylate tablet". dailymed.nlm.nih.gov. Archived from the original on 29 March 2021. Retrieved 12 January 2022.

[autogen1-5] ୫.୦ ^୫.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 441. ISBN 978-0857114105.

[autogen4-6] "Bromocriptine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 January 2021. Retrieved 12 January 2022.

[7] "Bromocriptine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2020. Retrieved 12 January 2022.

[Fis2006-8] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 533. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-06-30.

[9] "Bromocriptine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 7 November 2016. Retrieved 12 January 2022.

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Clinical data


Trade names	Parlodel, Cycloset, others^[୧]
Synonyms	Bromocriptine mesilate, bromocriptine mesylate, 2-Bromoergocriptine; CB-154
AHFS/Drugs.com	monograph
MedlinePlus	a682079
Pregnancy category	AU: A
Routes of administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	28% of oral dose
Metabolism	Extensively liver-mediated
Elimination half-life	12–14 hours
Excretion	85% bile (feces), 2.5–5.5% urine
Identifiers
IUPAC name (5′α)-2-Bromo-12′-hydroxy-5′-(2-methylpropyl)-3′,6′,18-trioxo-2′-(propan-2-yl)ergotaman
ECHA InfoCard	100.042.829
Chemical and physical data
Formula	C₃₂H₄₀BrN₅O₅
Molar mass	୬୫୪.୬୧ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES BrC1=C(C[C@H]2N(C)C3)C4=C(C=CC=C4C2=C[C@H]3C(N[C@]5(C(C)C)O[C@@]6(N([C@@H](CC(C)C)C(N7CCC[C@H]76)=O)C5=O)O)=O)N1
InChI InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1^Y Key:OZVBMTJYIDMWIL-AYFBDAFISA-N^Y
(verify)