ବ୍ରେମେଲାନୋଟାଇଡ

ବ୍ରେମେଲାନୋଟାଇଡ
Clinical data
Pronunciation	/ˌbrɛmɪˈlænətaɪd/ (listen)
Trade names	Vyleesi
Synonyms	Bremelanotide acetate; PT-141; Rekynda
AHFS/Drugs.com	monograph
MedlinePlus	a619054
data	US DailyMed: Bremelanotide;
Routes of; administration	Subcutaneous injection
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	SC: ~100%
Protein binding	21%
Metabolism	Hydrolysis of peptide bonds
Elimination half-life	2.7 hours
Excretion	Urine: 64.8%; Feces: 22.8%
Identifiers
	IUPAC name (3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid;
Chemical and physical data
Formula	C50H68N14O10
Molar mass	୧,୦୨୫.୧୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(C)N[C@@H](CCCC)C(N[C@@H]1C(N[C@@H](CC2=CNC=N2)C(N[C@H](CC3=CC=CC=C3)C(N[C@@H](CCC/N=C(N)\N)C(N[C@@H](CC4=CNC5C=CC=CC45)C(N[C@@H](CCCCNC(C1)=O)C(O)=O)=O)=O)=O)=O)=O)=O;
	InChI InChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9,13-15,17,26-28,35-41,56H,3-4,10-12,16,18-25H2,1-2H3,(H,53,57)(H,54,66)(H,58,65)(H,59,69)(H,60,70)(H,61,71)(H,62,68)(H,63,72)(H,64,67)(H,73,74)(H4,51,52,55)/t35-,36-,37-,38+,39-,40-,41-/m0/s1 ; Key:FFHBJDQSGDNCIV-MFVUMRCOSA-N ;
(verify)

ବ୍ରେମେଲାନୋଟାଇଡ, ବ୍ରାଣ୍ଡ ନାମ ଭାଲେସି, ଏକ ଔଷଧ ଯାହା ମହିଳାମାନଙ୍କର ନିମ୍ମ ଯୌନ ଇଚ୍ଛାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଏପରି କ୍ଷେତ୍ରରେ ବ୍ୟବହୃତ ହୁଏ ଯାହା ମେନୋପୋଜ ପୂର୍ବରୁ ଘଟିଥାଏ ଏବଂ ଚିକିତ୍ସା ସମସ୍ୟା, ମାନସିକ ସ୍ୱାସ୍ଥ୍ୟ କିମ୍ବା ସମ୍ପର୍କ ମଧ୍ୟରେ ସମସ୍ୟା ହେତୁ ହୋଇନଥାଏ ।^[୩] ଚର୍ମ ତଳେ ଇଞ୍ଜେକ୍ସନ୍ ଆକାରରେ ଏହା ଦିଆଯାଏ । ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ଇଞ୍ଜେକ୍ସନ୍ ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା, ମୁହଁ ଲାଲ ପଡ଼ିବା ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ । ^[୨] ଏହା ରକ୍ତଚାପକୁ ଅସ୍ଥାୟୀ ଭାବରେ ବୃଦ୍ଧି କରିପାରେ ଏବଂ ହୃଦସ୍ପନ୍ଦନକୁ ହ୍ରାସ କରିପାରେ ଏବଂ ମାଢ଼ି, ମୁହଁ ଏବଂ ସ୍ତନକୁ କଳା କରି ଦେଇପାରେ । ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୫] ଏହା ମାଲାନୋକର୍ଟିନ ରିସେପ୍ଋକୁ ସକ୍ରିୟ କରିପାରେ । ^[୩]

୨୦୧୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ବ୍ରେମେଲାନୋଟାଇଡ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୨] ଏହା ୟୁରୋପ କିମ୍ବା ବ୍ରିଟେନରେ ଅନୁମୋଦିତ ନୁହେଁ। ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ୨୦୨୨ ମସିହା ସୁଦ୍ଧା ପ୍ରାୟ ୬୦୦ ଡଲାର୍ ଅଟେ। ^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Vyleesi- bremelanotide injection". DailyMed. 10 September 2019. Archived from the original on 29 March 2021. Retrieved 20 November 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Bremelanotide Acetate Monograph for Professionals". Drugs.com. Archived from the original on 24 October 2019. Retrieved 24 October 2019.
↑ ^୩.୦ ^୩.୧ "Vyleesi- bremelanotide injection". DailyMed. 10 September 2019. Archived from the original on 29 March 2021. Retrieved 20 November 2019.
↑ "Bremelanotide Acetate Monograph for Professionals". Drugs.com. Archived from the original on 24 October 2019. Retrieved 24 October 2019.
↑ "Bremelanotide (Vyleesi) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 October 2020. Retrieved 11 January 2022.
↑ "Bremelanotide". SPS - Specialist Pharmacy Service. 22 September 2015. Archived from the original on 11 January 2022. Retrieved 11 January 2022.
↑ "Vyleesi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Vyleesi- bremelanotide injection". DailyMed. 10 September 2019. Archived from the original on 29 March 2021. Retrieved 20 November 2019.

[AHFS2019-2] ୨.୦ ^୨.୧ ^୨.୨ "Bremelanotide Acetate Monograph for Professionals". Drugs.com. Archived from the original on 24 October 2019. Retrieved 24 October 2019.

[PI2022-3] ୩.୦ ^୩.୧ "Vyleesi- bremelanotide injection". DailyMed. 10 September 2019. Archived from the original on 29 March 2021. Retrieved 20 November 2019.

[autogen3-4] "Bremelanotide Acetate Monograph for Professionals". Drugs.com. Archived from the original on 24 October 2019. Retrieved 24 October 2019.

[5] "Bremelanotide (Vyleesi) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 October 2020. Retrieved 11 January 2022.

[SP2022-6] "Bremelanotide". SPS - Specialist Pharmacy Service. 22 September 2015. Archived from the original on 11 January 2022. Retrieved 11 January 2022.

[7] "Vyleesi Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

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