ବ୍ରେକ୍ସପିପ୍ରାଜୋଲ

ବ୍ରେକ୍ସପିପ୍ରାଜୋଲ
Clinical data
Pronunciation	/brɛkˈspɪprəzoʊl/ BREK-SPIP-RƏ-zohl; /rɛkˈsʌlti/ rek-SUL-tee
Trade names	Rexulti, Rxulti
Synonyms	OPC-34712
AHFS/Drugs.com	monograph
MedlinePlus	a615046
data	EU EMA: yes; US DailyMed: Brexpiprazole;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	95% (Tmax = 4 hours)
Protein binding	>99%
Metabolism	Liver (mainly mediated by CYP3A4 and CYP2D6)
Elimination half-life	91 hours (brexpiprazole), 86 hours (major metabolite)
Excretion	Feces (46%), urine (25%)
Identifiers
	IUPAC name 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]quinolin-2(1H)-one;
ECHA InfoCard	100.242.305
Chemical and physical data
Formula	C25H27N3O2S
Molar mass	୪୩୩.୫୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C5/C=C\c4ccc(OCCCCN3CCN(c1cccc2sccc12)CC3)cc4N5;
	InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29); Key:ZKIAIYBUSXZPLP-UHFFFAOYSA-N;

ବ୍ରେକ୍ସପିପ୍ରାଜୋଲ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟନାମ ରେକ୍ସଲ୍ଟି, ହେଉଛି ଏକ ଆଟିପିକାଲ୍ ଆଣ୍ଟିସାଇକୋଟିକ୍ ଔଷଧ ଯାହା ସ୍କିଜୋଫ୍ରେନିଆ ଏବଂ ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀର (MDD) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ସ୍କିଜୋଫ୍ରେନିଆରେ ଏହା 12 ବର୍ଷରୁ ଅଧିକ ବୟସରେ ବ୍ୟବହୃତ ହୋଇପାରେ । ^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଓଜନ ବୃଦ୍ଧି ଏବଂ ଆକାଥିସିଆ ନାମକ ଏକ ଚଳପ୍ରଚଳ ଅସୁବିଧା ହୋଇପାରେ ।^[୪] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନ୍ୟୁରୋଲେପ୍ଟିକ୍ ମାଲିଗାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ, ଟାର୍ଡିଭ୍ ଡିସକାଇନେସିଆ, ମଧୁମେହ, ଜୁଆ ଖେଳ ସମସ୍ୟା ଏବଂ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ। ^[୫] ଡିମେନ୍ସିଆ ଥିବା ବୟସ୍କ ବ୍ୟକ୍ତିଙ୍କ ମୃତ୍ୟୁ ଆଶଙ୍କା ଅଧିକ ଥାଏ । ^[୫] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୭] ମସ୍ତିଷ୍କରେ ଏହା ଡୋପାମିନ, ସେରୋଟୋନୋନ ଓ ନରଆଡ୍ରେନାଲିନ ପ୍ରଭାବିତ କରି ଏହା କାମ କରେ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ । ^[୬]

୨୦୧୫ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୮ରେ ୟୁରୋପରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ବ୍ରେକ୍ସପିପ୍ରାଜୋଲ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୪] ^[୬] ୨୦୨୨ ସୁଦ୍ଧା ଏହା ବ୍ରିଟେନରେ ଉପଲବ୍ଧ ନୁହେଁ। ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୨ ସୁଦ୍ଧା ଏହାର ମାସକୁ ପ୍ରାୟ ୧୨୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com. 10 February 2020. Archived from the original on 5 December 2020. Retrieved 18 August 2020.
↑ "Summary for ARTG Entry:273224 Rexulti brexpiprazole 4 mg film coated tablets blisters". Therapeutic Goods Administration (TGA). Retrieved 18 August 2020.{{cite web}}: CS1 maint: url-status (link)
↑ "REXULTI® (brexpiprazole) Tablets, for Oral Use. Full Prescribing Information" (PDF). Rexulti (brexpiprazole) Patient Site. Otsuka Pharmaceutical Co., Ltd., Tokyo, 101-8535 Japan. Archived (PDF) from the original on 5 March 2016. Retrieved 15 July 2015.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "DailyMed - REXULTI- brexpiprazole tablet". dailymed.nlm.nih.gov. Archived from the original on 11 May 2021. Retrieved 11 January 2022.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "DailyMed - REXULTI- brexpiprazole tablet". dailymed.nlm.nih.gov. Archived from the original on 11 May 2021. Retrieved 11 January 2022.
↑ ^୬.୦ ^୬.୧ ^୬.୨ "Rxulti". Archived from the original on 12 January 2022. Retrieved 11 January 2022.
↑ "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 December 2020. Retrieved 11 January 2022.
↑ "Brexpiprazole". SPS - Specialist Pharmacy Service. 10 February 2016. Archived from the original on 12 January 2022. Retrieved 11 January 2022.
↑ "Brexpiprazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com. 10 February 2020. Archived from the original on 5 December 2020. Retrieved 18 August 2020.

[2] "Summary for ARTG Entry:273224 Rexulti brexpiprazole 4 mg film coated tablets blisters". Therapeutic Goods Administration (TGA). Retrieved 18 August 2020.{{cite web}}: CS1 maint: url-status (link)

[3] "REXULTI® (brexpiprazole) Tablets, for Oral Use. Full Prescribing Information" (PDF). Rexulti (brexpiprazole) Patient Site. Otsuka Pharmaceutical Co., Ltd., Tokyo, 101-8535 Japan. Archived (PDF) from the original on 5 March 2016. Retrieved 15 July 2015.

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ "DailyMed - REXULTI- brexpiprazole tablet". dailymed.nlm.nih.gov. Archived from the original on 11 May 2021. Retrieved 11 January 2022.

[autogen2-5] ୫.୦ ^୫.୧ ^୫.୨ "DailyMed - REXULTI- brexpiprazole tablet". dailymed.nlm.nih.gov. Archived from the original on 11 May 2021. Retrieved 11 January 2022.

[EPAR2022-6] ୬.୦ ^୬.୧ ^୬.୨ "Rxulti". Archived from the original on 12 January 2022. Retrieved 11 January 2022.

[7] "Brexpiprazole (Rexulti) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 December 2020. Retrieved 11 January 2022.

[SP2022-8] "Brexpiprazole". SPS - Specialist Pharmacy Service. 10 February 2016. Archived from the original on 12 January 2022. Retrieved 11 January 2022.

[9] "Brexpiprazole Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.

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Clinical data


Pronunciation	/brɛkˈspɪprəzoʊl/ BREK-SPIP-RƏ-zohl /rɛkˈsʌlti/ rek-SUL-tee
Trade names	Rexulti, Rxulti
Synonyms	OPC-34712
AHFS/Drugs.com	monograph
MedlinePlus	a615046
data	EU EMA: yes US DailyMed: Brexpiprazole
Pregnancy category	AU: C ^[୧] US: N (Not classified yet) ^[୧]
Routes of administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ^[୨] US: ℞-only EU: Rx-only
Pharmacokinetic data
Bioavailability	95% (Tmax = 4 hours)^[୩]
Protein binding	>99%
Metabolism	Liver (mainly mediated by CYP3A4 and CYP2D6)
Elimination half-life	91 hours (brexpiprazole), 86 hours (major metabolite)
Excretion	Feces (46%), urine (25%)
Identifiers
IUPAC name 7-[4-[4-(1-benzothiophen-4-yl)piperazin-1-yl]butoxy]quinolin-2(1H)-one
ECHA InfoCard	100.242.305
Chemical and physical data
Formula	C₂₅H₂₇N₃O₂S
Molar mass	୪୩୩.୫୭ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C5/C=C\c4ccc(OCCCCN3CCN(c1cccc2sccc12)CC3)cc4N5
InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29) Key:ZKIAIYBUSXZPLP-UHFFFAOYSA-N