ବେମ୍ପେଡୋଇକ ଏସିଡ

ବେମ୍ପେଡୋଇକ ଏସିଡ
Clinical data
Trade names	Nexletol, Nilemdo
Synonyms	ESP-55016, ETC-1002
AHFS/Drugs.com	monograph
MedlinePlus	a620020
data	EU EMA: yes; US DailyMed: Nexletol;
Pregnancy; category	Contraindicated;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	99.3%
Metabolism	Glucuronidation
Elimination half-life	21±11 hrs
Excretion	70% urine, 30% feces
Identifiers
	IUPAC name 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid;
ECHA InfoCard	100.238.679
Chemical and physical data
Formula	C19H36O5
Molar mass	୩୪୪.୪୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O;
	InChI InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24); Key:HYHMLYSLQUKXKP-UHFFFAOYSA-N;

ବେମ୍ପେଡୋଇକ ଏସିଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ନେକ୍ସଲେଟୋଲ, ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତକୋଲେଷ୍ଟ୍ରଲ୍ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ^[୫] ଏହା ୨୦୨୧ ସୁଦ୍ଧା ଆୟୁଷ କିମ୍ବା ଅକ୍ଷମତାକୁ ପ୍ରଭାବିତ କରେ କି ନାହିଁ ତାହା ଅସ୍ପଷ୍ଟ ଅଟେ । ^[୩] ଏହା ଏକ ଷ୍ଟାଟିନ୍ ସହିତ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ୟୁରିକ୍ ଏସିଡ୍, ବାହୁ କିମ୍ବା ଗୋଡରେ ଯନ୍ତ୍ରଣା ଏବଂ ସ୍ୱଳ୍ପ ଲାଲ ରକ୍ତ କଣିକା ହୋଇପାରେ । ^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା ଏବଂ ଟେଣ୍ଡନ୍ ଫାଟିଯାଇପାରେ । ^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୩] ଏହା ଯକୃତରେ ଥିବା ଆଡେନୋସିନ ଟ୍ରାଇଫୋସଫେଟ୍-ସାଇଟ୍ରେଟ୍ ଲ୍ୟାସେ ନାମକ ଏକ ଏନଜାଇମକୁ ଅବରୋଧ କରି କାମ କରେ, ଯାହା କୋଲେଷ୍ଟ୍ରଲ ତିଆରିରେ ଜଡିତ ଥାଏ । ^[୧]

୨୦୨୦ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ବେମ୍ପେଡିକ୍ ଏସିଡ୍ ଅନୁମୋଦିତ । ^[୪] ^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ୪ ସପ୍ତାହର କିଣା ମୂଲ୍ୟ ୨୦୨୧ ମସିହାରେ ୫୫ ପାଉଣ୍ଡ ଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୩୬୦ ଡଲାର ଅଟେ । ^[୭] ଏହା ବେମ୍ପେଡୋଇକ ଏସିଡ୍ / ଏଜେଟିମିବିର ମିଶ୍ରଣ ଭାବରେ ମଧ୍ୟ ଉପଲବ୍ଧ । ^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Nilemdo 180mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 4 September 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 221. ISBN 978-0857114105.
↑ "Nexletol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 January 2022.
↑ "Bempedoic Acid Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 9 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ ^୧.୨ "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[2] "Nilemdo 180mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 4 September 2020. Archived from the original on 22 January 2021. Retrieved 17 January 2021.

[autogen2-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ "Nexletol- bempedoic acid tablet, film coated". DailyMed. 10 March 2020. Archived from the original on 25 September 2020. Retrieved 19 March 2020.

[EPAR2022-5] ୫.୦ ^୫.୧ ^୫.୨ "Nilemdo EPAR". European Medicines Agency (EMA). 29 January 2020. Archived from the original on 4 August 2020. Retrieved 24 April 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[BNF81-6] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 221. ISBN 978-0857114105.

[7] "Nexletol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 9 January 2022.

[AHFS2022-8] "Bempedoic Acid Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 9 January 2022.

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