ବୁଟୋରଫାନୋଲ

ବୁଟୋରଫାନୋଲ
Clinical data
Pronunciation	bue tor’ fa nol
Trade names	Stadol, others
Synonyms	BC 2627
AHFS/Drugs.com	monograph
MedlinePlus	a682667
Pregnancy; category	C/D (United States);
Routes of; administration	IV, intranasal
Legal status
Legal status	AU: S8 (Controlled) ; CA: Schedule IV ; US: Schedule IV ;
Pharmacokinetic data
Bioavailability	Nasal: 60-70%; Sublingual: 25%-35%; PO 10%
Metabolism	Liver hydroxylated & glucuronidated
Onset of action	Within 15 min
Elimination half-life	4-7 hours
Duration of action	Up to 5 hrs
Excretion	Kidney, 75%; Biliary, 11-14%; Fecal, 15%
Identifiers
	IUPAC name (4bR, 8aR, 9S)-11-(cyclobutylmethyl)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano) phenanthrene-3,8a-diol;
ECHA InfoCard	100.050.717
Chemical and physical data
Formula	C21H29NO2
Molar mass	୩୨୭.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1=CC2=C(C=C1)C[C@H]3N(CC[C@@]24CCCC[C@@]34O)CC5CCC5;
	InChI InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1 ; Key:IFKLAQQSCNILHL-QHAWAJNXSA-N ;
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ବୁଟୋରଫାନୋଲ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ବେପାର ନାମ ଷ୍ଟାଡୋଲ, ଯନ୍ତ୍ରଣାକୁ ଚିକିତ୍ସା କରିବା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଓପିଓଏଡ <b id="mwDg">ଔଷଧ</b> । ^[୩] ନାକ ସ୍ପ୍ରେ ଭାବରେ ଏହା ଅଧକପାଳି ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୧] ଶିରା କିମ୍ବା ମାଂସପେଶୀରେ ଇଞ୍ଜେକ୍ସନ ଦେଇ ମଧ୍ୟମରୁ ପ୍ରବଳ ଯନ୍ତ୍ରଣାର ଚିକିତ୍ସା ପାଇଁ ଏହା ବ୍ୟବହାର କରାଯାଇପାରେ । ^[୧] ^[୪] ଏହାର ପ୍ରଭାବ ଆରମ୍ଭ ୧୫ ମିନିଟ ମଧ୍ୟରେ ହୁଏ ଏବଂ ଏହା ୫ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିପାରେ । ^[୨]

ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ଶ୍ୱାସକ୍ରିୟା ଅବସାଦ, ଦ୍ୱନ୍ଦ୍ୱ, ଉଚ୍ଚ ଅନୁଭବ, ଉତ୍ତେଜନା, ଗଲୁ, ଝାଳ, ବାନ୍ତି, ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ । ^[୩] ଅପବ୍ୟବହାରର ସମ୍ଭାବନା ଥିବାବେଳେ ଏହା ମର୍ଫିନରୁ କମ୍ ଅଟେ । ^[୧] ଗର୍ଭାବସ୍ଥାରେ ଦୀର୍ଘକାଳୀନ ବ୍ୟବହାର ଶିଶୁର ନିଓନାଟାଲ ଆବଷ୍ଟିନାନ୍ସ ସିଣ୍ଡ୍ରୋମ ହୋଇପାରେ । ^[୫] ଏହାର ଆଗୋନିଷ୍ଟ - ଆଣ୍ଟାଗୋନିଷ୍ଟ ପ୍ରଭାବ µ ଏବଂ ĸ ଟାଇପ୍ ଓପିଏଟ ରିସେପ୍ଟରଗୁଡ଼ିକ ଉପରେ ହୁଏ । ^[୧]

୧୯୭୧ ମସିହାରେ ବୁଟୋରଫାନୋଲ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୭୮ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୬] ^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଇଞ୍ଜେକ୍ସନ ପାଇଁ ୧ ମିଗ୍ରା ଭାଏଲର ମୂଲ୍ୟ ପ୍ରାୟ ୬ ଡଲାର । ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ ସିଡ୍ୟୁ୪ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ । ^[୧]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Butorphanol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 12 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Butorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 12 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Butorphanol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 12 January 2022.
↑ "Butorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 12 January 2022.
↑ "Butorphanol (Stadol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 12 January 2022.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 529. ISBN 978-3-527-60749-5. Archived from the original on 2021-06-14. Retrieved 2021-10-21.
↑ "Butorphanol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 12 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Butorphanol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 12 January 2022.

[autogen2-2] ୨.୦ ^୨.୧ ^୨.୨ "Butorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 12 January 2022.

[Liv2022-3] ୩.୦ ^୩.୧ ^୩.୨ "Butorphanol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 12 January 2022.

[AHFS2022-4] "Butorphanol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 12 January 2022.

[5] "Butorphanol (Stadol) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 12 January 2022.

[Fis2006-6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 529. ISBN 978-3-527-60749-5. Archived from the original on 2021-06-14. Retrieved 2021-10-21.

[7] "Butorphanol Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 12 January 2022.

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Clinical data


Pronunciation	bue tor’ fa nol^[୧]
Trade names	Stadol, others
Synonyms	BC 2627
AHFS/Drugs.com	monograph
MedlinePlus	a682667
Pregnancy category	C/D (United States)
Routes of administration	IV, intranasal
Legal status
Legal status	AU: S8 (Controlled) CA: Schedule IV US: Schedule IV
Pharmacokinetic data
Bioavailability	Nasal: 60-70%; Sublingual: 25%-35%; PO 10%
Metabolism	Liver hydroxylated & glucuronidated
Onset of action	Within 15 min^[୨]
Elimination half-life	4-7 hours
Duration of action	Up to 5 hrs^[୨]
Excretion	Kidney, 75% Biliary, 11-14% Fecal, 15%
Identifiers
IUPAC name (4bR, 8aR, 9S)-11-(cyclobutylmethyl)-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epiminoethano) phenanthrene-3,8a-diol
ECHA InfoCard	100.050.717
Chemical and physical data
Formula	C₂₁H₂₉NO₂
Molar mass	୩୨୭.୪୭ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES OC1=CC2=C(C=C1)C[C@H]3N(CC[C@@]24CCCC[C@@]34O)CC5CCC5
InChI InChI=1S/C21H29NO2/c23-17-7-6-16-12-19-21(24)9-2-1-8-20(21,18(16)13-17)10-11-22(19)14-15-4-3-5-15/h6-7,13,15,19,23-24H,1-5,8-12,14H2/t19-,20+,21-/m1/s1^Y Key:IFKLAQQSCNILHL-QHAWAJNXSA-N^Y
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