ପୋନେସିମୋଡ

ପୋନେସିମୋଡ
Clinical data
Trade names	Ponvory
Synonyms	ACT-128800
AHFS/Drugs.com	monograph
data	US DailyMed: Ponesimod;
Pregnancy; category	AU: D ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Metabolism	2 main metabolites
Elimination half-life	31–34 hrs
Excretion	Feces (57–80%, 26% unchanged), urine (10–18%)
Identifiers
	IUPAC name (2Z,5Z)-5-{3-Chloro-4-[(2R)-2,3-dihydroxypropoxy]benzylidene}-3-(2-methylphenyl)-2-(propylimino)-1,3-thiazolidin-4-one;
Chemical and physical data
Formula	C23H25ClN2O4S
Molar mass	୪୬୦.୯୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC/N=C\1/N(C(=O)/C(=C/C2=CC(=C(C=C2)OC[C@@H](CO)O)Cl)/S1)C3=CC=CC=C3C;
	InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1; Key:LPAUOXUZGSBGDU-STDDISTJSA-N;

ପୋନେସିମୋଡ, ପୋନଭୋରି ଏହାର ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମଲ୍ଟିପ୍ଲ ସ୍କ୍ଲେରୋସିସ୍ (MS) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୪] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବେ ଏହା ଆଇସୋଲେଟେଡ ସିଣ୍ଡ୍ରୋମ, ରିଲାପସିଙ୍ଗ- ରେମିଟିଙ୍ଗ୍ ରୋଗ ଏବଂ ସେକେଣ୍ଡାରୀ ପ୍ରଗତିଶୀଳ ରୋଗମାନଙ୍କରେ ବ୍ୟବହୃତ ହୁଏ ।^[୭] ଏହା ପାଟିରେ ଦିଆଯାଏ ।ଉ

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉର୍ଦ୍ଧ୍ୱ ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ, ଯକୃତ ପ୍ରଦାହ ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପ ହୋଇପାରେ ।^[୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସଂକ୍ରମଣ, ଧୀର ହୃଦସ୍ପନ୍ଦନ, ନିଶ୍ୱାସ ପ୍ରଶ୍ୱାସ ଏବଂ ଚର୍ମ କର୍କଟ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ | ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ । ଏହା ଏକ ସ୍ପିଙ୍ଗୋସିନ ୧-ଫସଫେଟ୍ ରିସେପ୍ଟର ମୋଡ୍ୟୁଲେଟର ଯାହା ଟି ଏବଂ ବି କୋଷଗୁଡ଼ିକର କାର୍ଯ୍ୟକଳାପକୁ ହ୍ରାସ କରିଥାଏ । ^[୭]

୨୦୨୧ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ପୋନେସିମୋଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୪ ସପ୍ତାହର ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ବାବଦ ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୧୧୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୁଲ୍ୟ ପ୍ରାୟ ୭୯୦୦ ଡଲାର ଅଟେ ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Ponvory APMDS". Therapeutic Goods Administration (TGA). 24 March 2022. Retrieved 4 April 2022.{{cite web}}: CS1 maint: url-status (link)
↑ "Summary Basis of Decision (SBD) for Ponvory". Health Canada. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
↑ "Ponvory EPAR". European Medicines Agency (EMA). 24 March 2021. Archived from the original on 19 March 2022. Retrieved 18 December 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Ponvory- ponesimod tablet, film coated Ponvory- ponesimod kit". DailyMed. Archived from the original on 21 January 2022. Retrieved 31 March 2021.
↑ Brossard P, Scherz M, Halabi A, Maatouk H, Krause A, Dingemanse J (February 2014). "Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1 receptor modulator: favorable impact of dose up-titration". Journal of Clinical Pharmacology. 54 (2): 179–88. doi:10.1002/jcph.244. PMID 24408162. S2CID 38041837.
↑ Reyes M, Hoch M, Brossard P, Wagner-Redeker W, Miraval T, Dingemanse J (February 2015). "Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45 (2): 139–49. doi:10.3109/00498254.2014.955832. PMID 25188442. S2CID 23905158.
↑ ^୭.୦ ^୭.୧ ^୭.୨ "European Medicines Agency Approval of Ponesimod". Archived from the original on 2021-08-04. Retrieved 2021-08-04.
↑ "Ponesimod". SPS - Specialist Pharmacy Service. 12 January 2016. Archived from the original on 20 January 2022. Retrieved 31 October 2022.
↑ "Ponvory". Archived from the original on 31 October 2022. Retrieved 31 October 2022.

[Ponvory_APMDS-1] ୧.୦ ^୧.୧ "Ponvory APMDS". Therapeutic Goods Administration (TGA). 24 March 2022. Retrieved 4 April 2022.{{cite web}}: CS1 maint: url-status (link)

[2] "Summary Basis of Decision (SBD) for Ponvory". Health Canada. Archived from the original on 30 May 2022. Retrieved 29 May 2022.

[Ponvory_EPAR-3] "Ponvory EPAR". European Medicines Agency (EMA). 24 March 2021. Archived from the original on 19 March 2022. Retrieved 18 December 2021.

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Ponvory- ponesimod tablet, film coated Ponvory- ponesimod kit". DailyMed. Archived from the original on 21 January 2022. Retrieved 31 March 2021.

[Brossard-5] Brossard P, Scherz M, Halabi A, Maatouk H, Krause A, Dingemanse J (February 2014). "Multiple-dose tolerability, pharmacokinetics, and pharmacodynamics of ponesimod, an S1P1 receptor modulator: favorable impact of dose up-titration". Journal of Clinical Pharmacology. 54 (2): 179–88. doi:10.1002/jcph.244. PMID 24408162. S2CID 38041837.

[Reyes-6] Reyes M, Hoch M, Brossard P, Wagner-Redeker W, Miraval T, Dingemanse J (February 2015). "Mass balance, pharmacokinetics and metabolism of the selective S1P1 receptor modulator ponesimod in humans". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45 (2): 139–49. doi:10.3109/00498254.2014.955832. PMID 25188442. S2CID 23905158.

[EPAR2022-7] ୭.୦ ^୭.୧ ^୭.୨ "European Medicines Agency Approval of Ponesimod". Archived from the original on 2021-08-04. Retrieved 2021-08-04.

[8] "Ponesimod". SPS - Specialist Pharmacy Service. 12 January 2016. Archived from the original on 20 January 2022. Retrieved 31 October 2022.

[9] "Ponvory". Archived from the original on 31 October 2022. Retrieved 31 October 2022.

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