ପେରାମପାନେଲ

ପେରାମପାନେଲ
Clinical data
Trade names	Fycompa
Synonyms	E2007
AHFS/Drugs.com	monograph
MedlinePlus	a614006
data	EU EMA: yes; US DailyMed: Perampanel;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: Schedule III ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	116%
Protein binding	95–96%
Metabolism	Hepatic, mostly via CYP3A4 and/or CYP3A5
Elimination half-life	105 hours, 295 hours (moderate hepatic impairment)
Excretion	70% faeces, 30% urine
Identifiers
	IUPAC name 5'-(2-cyanophenyl)-1'-phenyl-2,3'-bipyridinyl-6'(1H)-one;
ECHA InfoCard	100.219.846
Chemical and physical data
Formula	C23H15N3O
Molar mass	୩୪୯.୩୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc2ccccc2-c1cc(-c4ncccc4)cn(c1=O)-c3ccccc3;
	InChI InChI=1S/C23H15N3O/c24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22) 16-26(23(21)27)19-9-2-1-3-10-19/h1-14,16H ; Key:PRMWGUBFXWROHD-UHFFFAOYSA-N ;
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ପେରାମପାନେଲ, ଏକ ବିକ୍ରୟ ନାମ ଫାଇକୋମ୍ପା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଆଂଶିକ ବାତ ଏବଂ ସାଧାରଣ ଟନିକ୍-କ୍ଲୋନିକ୍ ବାତ ଆକ୍ରାନ୍ତ ରୋଗୀର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ହୁଏତ ଅନ୍ୟ ଔଷଧ ମିଶ୍ରଣ ବ୍ୟତୀତ କିମ୍ବା ସ‌ହିତ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ^[୭] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁଭାବ, ବିରକ୍ତିକରତା, ଅଇ, ଓଜନ ବୃଦ୍ଧି ଏବଂ ଶାରୀରିକ ସମନ୍ୱୟର ଅଭାବ ହୋଇପାରେ ।^[୭] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହତ୍ୟା କିମ୍ବା ଆତ୍ମହତ୍ୟା ଚିନ୍ତାଧାରା, ଔଷଧ ପ୍ରତିକ୍ରିୟା ସ‌ହିତ ଇଓସିନୋଫିଲିଆ ଏବଂ ସିଷ୍ଟମିକ୍ ଲକ୍ଷଣ (DRESS) ଏବଂ ଅପବ୍ୟବହାର ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୪] ଏହା ଲେଭୋନରଜେଷ୍ଟ୍ରଲ୍ ଗ୍ରହଣ କରୁଥିବା ଜନ୍ମ ନିୟନ୍ତ୍ରଣର ପ୍ରଭାବକୁ ମଧ୍ୟ ହ୍ରାସ କରିଥାଏ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି କରିପାରେ ।^[୮] ଏହା ଆମ୍ପା ରିସେପ୍ଟରକୁ (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, also known as AMPA receptor) ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୯]

୨୦୧୨ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ପେରାମପାନେଲ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬]^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ୪ ସପ୍ତାହର ଔଷଧ ଖର୍ଚ୍ଚ ୨୦୨୧ ମସିହାରେ ପ୍ରାୟ ୧୦୦୦୦ ଡଲାର ଥିଲା ।^[୧୦] ଡ୍ରଗ୍ ଏନଫୋର୍ସମେଣ୍ଟ ଆଡମିନିଷ୍ଟ୍ରେସନ‌ଦ୍ୱାରା ଏହା ଏକ ସିଡ୍ୟୁଲ୍ ତୃତୀୟ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ ଭାବରେ ବିବେଚିତ ଅଟେ ।^[୪]

ଆଧାର

↑ "AusPAR: Perampanel hemisesquihydrate". Therapeutic Goods Administration (TGA). 10 May 2021. Archived from the original on 13 June 2021. Retrieved 12 June 2021.
↑ https://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=52B9101BC60D00B2CA25867E003CC743&agid=(PrintDetailsPublic)&actionid=1^{[permanent dead link]}
↑ "TGA eBS - Product and Consumer Medicine Information Licence". Archived from the original on 2021-06-13. Retrieved 2021-09-13.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Fycompa- perampanel tablet Fycompa- perampanel suspension". DailyMed. Archived from the original on 13 June 2021. Retrieved 12 June 2021.
↑ Yang X, Wu TC, Yuxin MA, Lee JY, Bhattaram VA, Mehta MU. "U.S. FDA Clinical Pharmacology Review. Fycompa (perampanel)" (PDF): 25. Archived (PDF) from the original on 2017-05-06. Retrieved 2021-09-13. {{cite journal}}: Cite journal requires |journal= (help)
↑ ^୬.୦ ^୬.୧ "Fycompa". Archived from the original on 19 October 2021. Retrieved 27 October 2021.
↑ ^୭.୦ ^୭.୧ ^୭.୨ "Perampanel Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 June 2021. Retrieved 27 October 2021.
↑ "Perampanel (Fycompa) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 27 October 2021.
↑ Chong DJ, Lerman AM (April 2016). "Practice Update: Review of Anticonvulsant Therapy". Current Neurology and Neuroscience Reports. 16 (4): 39. doi:10.1007/s11910-016-0640-y. PMID 26984292.
↑ "Fycompa Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 January 2021. Retrieved 27 October 2021.

[AusPAR:_Perampanel_hemisesquihydrate-1] "AusPAR: Perampanel hemisesquihydrate". Therapeutic Goods Administration (TGA). 10 May 2021. Archived from the original on 13 June 2021. Retrieved 12 June 2021.

[2] ttps://www.ebs.tga.gov.au/servlet/xmlmillr6?dbid=ebs/PublicHTML/pdfStore.nsf&docid=52B9101BC60D00B2CA25867E003CC743&agid=(PrintDetailsPublic)&actionid=1^{[permanent dead link]}

[3] "TGA eBS - Product and Consumer Medicine Information Licence". Archived from the original on 2021-06-13. Retrieved 2021-09-13.

[PI2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Fycompa- perampanel tablet Fycompa- perampanel suspension". DailyMed. Archived from the original on 13 June 2021. Retrieved 12 June 2021.

[5] Yang X, Wu TC, Yuxin MA, Lee JY, Bhattaram VA, Mehta MU. "U.S. FDA Clinical Pharmacology Review. Fycompa (perampanel)" (PDF): 25. Archived (PDF) from the original on 2017-05-06. Retrieved 2021-09-13. {{cite journal}}: Cite journal requires |journal= (help)

[EPAR2021-6] ୬.୦ ^୬.୧ "Fycompa". Archived from the original on 19 October 2021. Retrieved 27 October 2021.

[AHFS2021-7] ୭.୦ ^୭.୧ ^୭.୨ "Perampanel Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 June 2021. Retrieved 27 October 2021.

[Preg2021-8] "Perampanel (Fycompa) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 27 October 2021.

[Chong2016rev-9] Chong DJ, Lerman AM (April 2016). "Practice Update: Review of Anticonvulsant Therapy". Current Neurology and Neuroscience Reports. 16 (4): 39. doi:10.1007/s11910-016-0640-y. PMID 26984292.

[10] "Fycompa Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 January 2021. Retrieved 27 October 2021.

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