ଉଇକିପିଡ଼ିଆ

ନେସିରିଟାଇଡ

ନେସିରିଟାଇଡ (ଇଂରାଜୀ ଭାଷାରେ Nesiritide), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ନାଟ୍ରେକୋର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ତୀବ୍ର ଅଣକ୍ଷତିପୁର୍ତ୍ତ ହୃଦଘାତର ଚିକିତ୍ସା ପାଇଁ ବିକଶିତ ହୋଇଛି ।[୧] ତଥାପି ଉପକାରର ପ୍ରମାଣ ଦେଖାଇବାରେ ବିଫଳ ହୋଇଛି ।[୨] [୧] ଏହାକୁ ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।[୧]

ନେସିରିଟାଇଡ
Clinical data
AHFS/Drugs.commonograph
Routes of
administration		IV only
Chemical and physical data
FormulaC143H244N50O42S4
Molar mass୩,୪୬୪.୦୭ g·mol−1
3D model (JSmol)
  • CC[C@H](C)[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CCCNC(=N)N)CC(=O)O)CCSC)CCCCN)CCCNC(=N)N)CC2=CC=CC=C2)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CO)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC4=CNC=N4)C(=O)O)CC(C)C)CO)CO)CO)CO
  • InChI=1S/C143H244N50O42S4/c1-13-76(10)112-137(232)189-99(68-199)131(226)188-98(67-198)130(225)187-97(66-197)129(224)186-96(65-196)117(212)166-59-105(202)169-90(52-72(2)3)114(209)163-61-107(204)171-100(132(227)177-83(32-19-22-44-146)124(219)190-111(75(8)9)136(231)184-91(53-73(4)5)127(222)175-84(34-24-46-159-141(151)152)121(216)174-85(35-25-47-160-142(153)154)122(217)185-94(139(234)235)55-78-57-157-71-167-78)69-238-239-70-101(172-108(205)62-165-116(211)95(64-195)170-106(203)60-162-113(208)87(38-39-103(148)200)181-135(230)110(74(6)7)191-126(221)89(41-51-237-12)179-120(215)82(31-18-21-43-145)180-134(229)102-37-27-49-193(102)138(233)79(147)63-194)133(228)182-92(54-77-28-15-14-16-29-77)115(210)164-58-104(201)168-80(33-23-45-158-140(149)150)118(213)173-81(30-17-20-42-144)119(214)178-88(40-50-236-11)123(218)183-93(56-109(206)207)128(223)176-86(125(220)192-112)36-26-48-161-143(155)156/h14-16,28-29,57,71-76,79-102,110-112,194-199H,13,17-27,30-56,58-70,144-147H2,1-12H3,(H2,148,200)(H,157,167)(H,162,208)(H,163,209)(H,164,210)(H,165,211)(H,166,212)(H,168,201)(H,169,202)(H,170,203)(H,171,204)(H,172,205)(H,173,213)(H,174,216)(H,175,222)(H,176,223)(H,177,227)(H,178,214)(H,179,215)(H,180,229)(H,181,230)(H,182,228)(H,183,218)(H,184,231)(H,185,217)(H,186,224)(H,187,225)(H,188,226)(H,189,232)(H,190,219)(H,191,221)(H,192,220)(H,206,207)(H,234,235)(H4,149,150,158)(H4,151,152,159)(H4,153,154,160)(H4,155,156,161)/t76-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,110-,111-,112-/m0/s1 ☒N
  • Key:HPNRHPKXQZSDFX-OAQDCNSJSA-N ☒N
  (verify)

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ମୁଣ୍ଡବିନ୍ଧା, ଅଇ, ଏବଂ ପିଠି ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ବୃକ୍‌କ ସମସ୍ୟା ଏବଂ ମୃତ୍ୟୁ ହୋଇପାରେ ।[୧] ଏହା ବି-ପ୍ରକାରର ନାଟ୍ରିୟୁରେଟିକ୍ ପେପ୍ଟାଇଡର ଏକ ରେକମ୍ବିନାଣ୍ଟ ଆକାର ଯାହା ଫଳରେ ରକ୍ତନଳୀ ସ୍ଫିତାବସ୍ଥାରେ ପରିଣତ ହୁଏ ।[୧]

୨୦୦୧ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ନେସିରିଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧.୫ ମିଲିଗ୍ରାମ ବିଶିଷ୍ଟ ଭାଏଲର ମୂଲ୍ୟ ୧୧୦୦ ଡଲାର ।[୩] ବାଣିଜ୍ୟିକ ବିକ୍ରୟ ୨୦୨୧ ସୁଦ୍ଧା ବନ୍ଦ ହୋଇଯାଇଛି ।[୪]

ଆଧାର

ସମ୍ପାଦନା
  1. ↑ ୧.୦ ୧.୧ ୧.୨ ୧.୩ ୧.୪ ୧.୫ ୧.୬ "Nesiritide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 June 2020. Retrieved 12 November 2021.
  2. ↑ O'Connor CM, Starling RC, Hernandez AF, Armstrong PW, Dickstein K, Hasselblad V, Heizer GM, Komajda M, Massie BM, McMurray JJ, Nieminen MS, Reist CJ, Rouleau JL, Swedberg K, Adams KF, Anker SD, Atar D, Battler A, Botero R, Bohidar NR, Butler J, Clausell N, Corbalán R, Costanzo MR, Dahlstrom U, Deckelbaum LI, Diaz R, Dunlap ME, Ezekowitz JA, Feldman D, Felker GM, Fonarow GC, Gennevois D, Gottlieb SS, Hill JA, Hollander JE, Howlett JG, Hudson MP, Kociol RD, Krum H, Laucevicius A, Levy WC, Méndez GF, Metra M, Mittal S, Oh BH, Pereira NL, Ponikowski P, Tang WH, Wilson WH, Tanomsup S, Teerlink JR, Triposkiadis F, Troughton RW, Voors AA, Whellan DJ, Zannad F, Califf RM (July 2011). "Effect of nesiritide in patients with acute decompensated heart failure" (PDF). The New England Journal of Medicine. 365 (1): 32–43. doi:10.1056/NEJMoa1100171. PMID 21732835. Archived from the original (PDF) on 2021-02-11. Retrieved 2021-09-18. {{cite journal}}: |hdl-access= requires |hdl= (help); Unknown parameter |displayauthors= ignored (|display-authors= suggested) (help)
  3. ↑ "Natrecor Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 12 November 2021.
  4. ↑ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Archived from the original on 21 March 2021. Retrieved 12 November 2021.
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