ନିସୋଲଡିପାଇନ

ନିସୋଲଡିପାଇନ
Clinical data
Pronunciation	nye sol' di peen
Trade names	Sular, Baymycard, Syscor, others
AHFS/Drugs.com	monograph
MedlinePlus	a696009
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	4–8%
Protein binding	>99%
Metabolism	CYP3A4
Elimination half-life	7–12 hours
Excretion	70–80% via urine
Identifiers
	IUPAC name (RS)-Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;
ECHA InfoCard	100.058.534
Chemical and physical data
Formula	C20H24N2O6
Molar mass	388.414
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)c2ccccc2[N+](=O)[O-])C(=O)OC;
	InChI InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3; Key:VKQFCGNPDRICFG-UHFFFAOYSA-N;
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ନିସୋଲଡିପାଇନ (ଇଂରାଜୀ ଭାଷାରେ Nisoldipine), ସୁଲାର ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଉଚ୍ଚ ରକ୍ତଚାପର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୨] ଏହାକୁ ଅନ୍ୟ ଔଷଧ ସହିତ କିମ୍ବା ସ୍ୱତନ୍ତ୍ର ଭାବରେ ବ୍ୟବହୃତ ହୋଇପାରେ । ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଫୁଲା, ମୁଣ୍ଡବିନ୍ଧା, ଦୃତ ହୃଦ୍‌ଗତି, ଅଇ ଏବଂ ରାସ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଞ୍ଜାଇନା, ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କରିବା ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନଥିବାବେଳେ ସଙ୍କଟ କମ ଥାଏ ।^[୩] ଏହା ଡାଇହାଇଡ୍ରୋପାଇରିଡାଇନ ଶ୍ରେଣୀର ଏକ କ୍ୟାଲସିୟମ ଚ୍ୟାନେଲ ବ୍ଲକର୍ (CCB) | ^[୨] ଏହା ଧମନୀଗୁଡ଼ିକୁ ସ୍ଫିତ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧]

ନିସୋଲଡିପାଇନ ୧୯୭୫ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇ ୧୯୯୦ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ୧୯୯୫ ମସିହାରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ହୁଏ ।^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ବ୍ୟବ‌ହାର ନିମନ୍ତେ ମାସକୁ ୫୪ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Nisoldipine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Nisoldipine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 September 2021. Retrieved 13 November 2021.
↑ "Nisoldipine (Sular) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 September 2021. Retrieved 13 November 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 464. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-12-04.
↑ "Nisoldipine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 November 2021.

[Liv2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Nisoldipine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Nisoldipine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 September 2021. Retrieved 13 November 2021.

[3] "Nisoldipine (Sular) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 September 2021. Retrieved 13 November 2021.

[4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 464. ISBN 9783527607495. Archived from the original on 2021-08-29. Retrieved 2020-12-04.

[5] "Nisoldipine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 November 2021.

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Clinical data


Pronunciation	nye sol' di peen^[୧]
Trade names	Sular, Baymycard, Syscor, others
AHFS/Drugs.com	monograph
MedlinePlus	a696009
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	4–8%
Protein binding	>99%
Metabolism	CYP3A4
Elimination half-life	7–12 hours
Excretion	70–80% via urine
Identifiers
IUPAC name (RS)-Isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
ECHA InfoCard	100.058.534
Chemical and physical data
Formula	C₂₀H₂₄N₂O₆
Molar mass	388.414
3D model (JSmol)	Interactive image
SMILES CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)c2ccccc2[N+](=O)[O-])C(=O)OC
InChI InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3 Key:VKQFCGNPDRICFG-UHFFFAOYSA-N
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