ନିଟାଜୋକ୍ସାନାଇଡ

ନିଟାଜୋକ୍ସାନାଇଡ
Clinical data
Pronunciation	nye" ta zox' a nide
Trade names	Alinia, Nizonide, others
AHFS/Drugs.com	monograph
MedlinePlus	a603017
data	US DailyMed: Nitazoxanide;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Protein binding	Nitazoxanide: ?; Tizoxanide: over 99%
Metabolism	Rapidly hydrolyzed to tizoxanide
Metabolites	tizoxanide; tizoxanide glucuronide
Elimination half-life	3.5 hours
Excretion	Kidney, bile duct, and fecal
Identifiers
	IUPAC name [2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate;
ECHA InfoCard	100.054.465
Chemical and physical data
Formula	C12H9N3O5S
Molar mass	୩୦୭.୨୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(Nc1ncc(s1)[N+]([O-])=O)c2ccccc2OC(=O)C;
	InChI InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17) ; Key:YQNQNVDNTFHQSW-UHFFFAOYSA-N ;
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,

ନିଟାଜୋକ୍ସାନାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଆଲିନିଆ ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ବିଭିନ୍ନ ଏକ କୋଷୀ ଜୀବ ପ୍ରୋଟୋଜୋଆ ଏବଂ ପରଜୀବୀ ପୋକମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୧] ଏଥିରେ କ୍ରିପ୍ଟୋସ୍ପୋରିଡିଓସିସ, ଜିଆର୍ଡିଆସିସ୍, ଆମିବାୟାସିସ୍, ଆଇସୋସ୍ପୋରିଆସିସ ଏବଂ କିଛି ଟେପୱର୍ମ, ଫ୍ଲାଟୱର୍ମ ବା ଫ୍ଲୁକ୍ ଏବଂ ଜିଆ ଅନ୍ତର୍ଭୁକ୍ତ। ^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ଅଇ, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ଅସ୍ୱାଭାବିକ ରଙ୍ଗର ପରିସ୍ରା ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ । ^[୫] ଏହା ଏକ ଥିଆଜୋଲାଇଡ୍ ଯାହା ପିରୁଭେଟ୍ ଫେରେଡୋକ୍ସିନ୍ ଅକ୍ସିଡୋରଡେକ୍ଟେଜ୍ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୧]

୨୦୦୨ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ନିମନ୍ତେ ନିଟାଜୋକ୍ସାନାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ଏହାକୁ ୨୦୨୦ ମସିହାରେ ଜେନେରିକ୍ ଔଷଧ ଭାବରେ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୫୦୦ ମିଗ୍ରାର ୬ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୨୪୦ ଡଲାର ଥିଲା ।^[୭] ଇନ୍‌ଫ୍ଲୁଏଞ୍ଜା ପାଇଁ ଏହାର ବ୍ୟବହାରକୁ ନେଇ ୨୦୨୧ ସୁଦ୍ଧା ଅନୁସନ୍ଧାନ ଜାରି ରହିଛି ।^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Nitazoxanide". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Alinia- nitazoxanide tablet Alinia- nitazoxanide powder, for suspension". DailyMed. Archived from the original on 20 March 2021. Retrieved 13 February 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther. 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.
↑ Nitazoxanide. National Center for Biotechnology Information. Archived from the original on 6 March 2016. Retrieved 3 January 2016. {{cite encyclopedia}}: |work= ignored (help)
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Nitazoxanide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 August 2020. Retrieved 13 November 2021.
↑ "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 26 January 2021. Retrieved 13 February 2021.
↑ "Nitazoxanide Prices and Nitazoxanide Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 13 November 2021.
↑ "Nitazoxanide". SPS - Specialist Pharmacy Service. 14 January 2016. Archived from the original on 13 November 2021. Retrieved 13 November 2021.

[Liv2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Nitazoxanide". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 13 November 2021. Retrieved 13 November 2021.

[PI2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Alinia- nitazoxanide tablet Alinia- nitazoxanide powder, for suspension". DailyMed. Archived from the original on 20 March 2021. Retrieved 13 February 2021.

[Primary:_Kinetics_and_OD-3] ୩.୦ ^୩.୧ ^୩.୨ Stockis A, Allemon AM, De Bruyn S, Gengler C (May 2002). "Nitazoxanide pharmacokinetics and tolerability in man using single ascending oral doses". Int J Clin Pharmacol Ther. 40 (5): 213–220. doi:10.5414/cpp40213. PMID 12051573.

[PubChem-4] Nitazoxanide. National Center for Biotechnology Information. Archived from the original on 6 March 2016. Retrieved 3 January 2016. {{cite encyclopedia}}: |work= ignored (help)

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Nitazoxanide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 August 2020. Retrieved 13 November 2021.

[6] "First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). Archived from the original on 26 January 2021. Retrieved 13 February 2021.

[7] "Nitazoxanide Prices and Nitazoxanide Coupons - GoodRx". GoodRx. Archived from the original on 1 November 2016. Retrieved 13 November 2021.

[8] "Nitazoxanide". SPS - Specialist Pharmacy Service. 14 January 2016. Archived from the original on 13 November 2021. Retrieved 13 November 2021.

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Clinical data


Pronunciation	nye" ta zox' a nide^[୧]
Trade names	Alinia, Nizonide, others
AHFS/Drugs.com	monograph
MedlinePlus	a603017
data	US DailyMed: Nitazoxanide
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only ^[୨]
Pharmacokinetic data
Protein binding	Nitazoxanide: ? Tizoxanide: over 99%^[୨]^[୩]
Metabolism	Rapidly hydrolyzed to tizoxanide^[୨]
Metabolites	tizoxanide^[୨]^[୩] tizoxanide glucuronide^[୨]^[୩]
Elimination half-life	3.5 hours^[୪]
Excretion	Kidney, bile duct, and fecal^[୨]
Identifiers
IUPAC name [2-[(5-Nitro-1,3-thiazol-2-yl)carbamoyl]phenyl]ethanoate
ECHA InfoCard	100.054.465
Chemical and physical data
Formula	C₁₂H₉N₃O₅S
Molar mass	୩୦୭.୨୮ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(Nc1ncc(s1)[N+]([O-])=O)c2ccccc2OC(=O)C
InChI InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)^Y Key:YQNQNVDNTFHQSW-UHFFFAOYSA-N^Y
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