ଡିଫେଲାଇକଫଲିନ

ଡିଫେଲାଇକଫଲିନ
Clinical data
Trade names	Korsuva, Kapruvia
Synonyms	CR845, FE-202845, D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid]
AHFS/Drugs.com	monograph
data	US DailyMed: Difelikefalin;
Routes of; administration	Intravenous
Legal status
Legal status	CA: ℞-only ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	100% (IV)
Metabolism	Not metabolized
Elimination half-life	2 hours
Excretion	Excreted as unchanged; drug via bile and urine
Identifiers
	IUPAC name 4-amino-1-[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid;
Chemical and physical data
Formula	C36H53N7O6
Molar mass	୬୭୯.୮୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C[C@H](C(=O)N[C@H](CCCCN)C(=O)N1CCC(CC1)(C(=O)O)N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@@H](CC3=CC=CC=C3)N;
	InChI InChI=1S/C36H53N7O6/c1-24(2)21-29(32(45)40-28(15-9-10-18-37)34(47)43-19-16-36(39,17-20-43)35(48)49)42-33(46)30(23-26-13-7-4-8-14-26)41-31(44)27(38)22-25-11-5-3-6-12-25/h3-8,11-14,24,27-30H,9-10,15-23,37-39H2,1-2H3,(H,40,45)(H,41,44)(H,42,46)(H,48,49)/t27-,28-,29-,30-/m1/s1; Key:FWMNVWWHGCHHJJ-SKKKGAJSSA-N;

ଡିଫେଲାଇକଫଲିନ (ଇଂରାଜୀ ଭାଷାରେ Difelikefalin), କୋର୍ସୁଭା ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରନିକ୍ ବୃକ୍‌କ ରୋଗ ଯୋଗୁ ହେମୋଡାଏଲିସିସ୍ ରୋଗୀଙ୍କଠାରେ ଗଲୁ ଉପଶମ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ମଧ୍ୟମରୁ ଗୁରୁତର କ୍ଷେତ୍ରରେ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୬] ଡାଏଲିସିସ ଶେଷରେ ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ମୁଣ୍ଡ ବୁଲାଇବା, ଅଇ, ପଡ଼ିଯିବାର ଆଶଙ୍କା, ଉଚ୍ଚ ରକ୍ତ ପୋଟାସିୟମ୍, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ନିଦ୍ରା:ଭାବ ହୋଇପାରେ ।^[୪] ଯକୃତ ଜନିତ ସମସ୍ୟା ଥିବା ଲୋକଙ୍କଠାରେ ଏହାକୁ ବ୍ୟବହାର କରିବା ଉଚିତ୍ ନୁହେଁ ।^[୪] ଏହା ଏକ କପ୍ପା ଓପିଓଏଡ ରିସେପ୍ଟର ଆଗୋନିଷ୍ଟ (KOR) ଯାହା ଗଲୁ ଏବଂ ପ୍ରଦାହକୁ ହ୍ରାସ କରିବା ପାଇଁ ନିର୍ଦ୍ଦିଷ୍ଟ ସ୍ନାୟୁ ଏବଂ ପ୍ରତିରକ୍ଷା କୋଷ ସହିତ ସଂଯୁକ୍ତ ହୋଇଥାଏ ।^[୧]

୨୦୨୧ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୨ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଡିଫେଲାଇକଫଲିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୧] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୨ ସୁଦ୍ଧା ଏକ ଭାଏଲ ପିଛା ୪୨୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ପିଛା ମାସକୁ ପ୍ରାୟ ୨୦୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୭]

ଆଧାର ସମ୍ପାଦନା

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Kapruvia EPAR". European Medicines Agency (EMA). 22 February 2022. Archived from the original on 6 May 2022. Retrieved 28 April 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ Janecka A, Perlikowska R, Gach K, Wyrebska A, Fichna J (2010). "Development of opioid peptide analogs for pain relief". Curr. Pharm. Des. 16 (9): 1126–35. doi:10.2174/138161210790963869. PMID 20030621.
↑ https://pdf.hres.ca/dpd_pm/00066996.PDF Archived 2022-10-01 at the Wayback Machine. ଛାଞ୍ଚ:Bare URL PDF
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Korsuva- difelikefalin injection, solution". DailyMed. Archived from the original on 12 September 2021. Retrieved 12 September 2021.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ Raymond S. Sinatra; Jonathan S. Jahr; J. Michael Watkins-Pitchford (14 October 2010). The Essence of Analgesia and Analgesics. Cambridge University Press. pp. 490–491. ISBN 978-1-139-49198-3.
↑ ^୬.୦ ^୬.୧ "Difelikefalin". SPS - Specialist Pharmacy Service. 10 December 2015. Archived from the original on 24 October 2021. Retrieved 28 October 2022.
↑ Watnick, Suzanne; Butler, Catherine R. (August 2022). "Difelikefalin: A Novel Therapy for Dialysis Patient Care". Kidney Medicine. 4 (8): 100519. doi:10.1016/j.xkme.2022.100519.

[EPAR2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Kapruvia EPAR". European Medicines Agency (EMA). 22 February 2022. Archived from the original on 6 May 2022. Retrieved 28 April 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[pmid20030621-2] Janecka A, Perlikowska R, Gach K, Wyrebska A, Fichna J (2010). "Development of opioid peptide analogs for pain relief". Curr. Pharm. Des. 16 (9): 1126–35. doi:10.2174/138161210790963869. PMID 20030621.

[3] ttps://pdf.hres.ca/dpd_pm/00066996.PDF Archived 2022-10-01 at the Wayback Machine. ଛାଞ୍ଚ:Bare URL PDF

[PI2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Korsuva- difelikefalin injection, solution". DailyMed. Archived from the original on 12 September 2021. Retrieved 12 September 2021.

[SinatraJahr2010-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ Raymond S. Sinatra; Jonathan S. Jahr; J. Michael Watkins-Pitchford (14 October 2010). The Essence of Analgesia and Analgesics. Cambridge University Press. pp. 490–491. ISBN 978-1-139-49198-3.

[SPS2022-6] ୬.୦ ^୬.୧ "Difelikefalin". SPS - Specialist Pharmacy Service. 10 December 2015. Archived from the original on 24 October 2021. Retrieved 28 October 2022.

[7] Watnick, Suzanne; Butler, Catherine R. (August 2022). "Difelikefalin: A Novel Therapy for Dialysis Patient Care". Kidney Medicine. 4 (8): 100519. doi:10.1016/j.xkme.2022.100519.

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