ଡିଫାଇବ୍ରୋଟାଇଡ

ଡିଫାଇବ୍ରୋଟାଇଡ
Clinical data
Trade names	Defitelio
Synonyms	Defibrotide sodium
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Pregnancy; category	AU: D ; US: N (Not classified yet) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	58 - 70% by mouth (i.v. and i.m. = 100%)
Elimination half-life	< 2 hours
(verify)

ଡିଫାଇବ୍ରୋଟାଇଡ, ଡିଫିଟେଲିଓରେ ଏହାର ବିକ୍ରୟ ନାମ, ହେଉଛି, ଏକ ଔଷଧ ଯାହା ଅସ୍ଥି ମଜ୍ଜା ପ୍ରତିରୋପଣ ପରବର୍ତ୍ତୀ ଯକୃତର ଭେନୋ-ଅକ୍ଲୁସିଭ ରୋଗର (veno-occlusive disease) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୬] ଏହାର ବ୍ୟବହାରକୁ ସମର୍ଥନ କରିବାକୁ ଉଚ୍ଚ ମାନର ପ୍ରମାଣ ଅଭାବ ଅଛି ।^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ଅଇ, ଏବଂ ରକ୍ତସ୍ରାବ ହୋଇପାରେ ।^[୩] ^[୫] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୫] ରକ୍ତ ଜମାଟରୋଧୀ ଔଷଧ ପାଉଥିବା ଲୋକଙ୍କ ଉପରେ ଏହା ବ୍ୟବହାର କରାଯିବା ଉଚିତ ନୁହେଁ | ^[୫] ଏହା ଓଲିଗୋନ୍ୟୁକ୍ଲିଓଟାଇଡମାନଙ୍କର ଏକ ମିଶ୍ରଣ ଏବଂ ଏଣ୍ଡୋଥେଲିଆଲ୍ ଜୀବକୋଷ ସକ୍ରିୟତା ହ୍ରାସ କରି କିଛି ଅଂଶରେ କାମ କରେ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୪]

୨୦୧୩ ମସିହାରେ ୟୁରୋପରେ, ୨୦୨୬ରେ ଆମେରିକାରେ ଏବଂ ୨୦୨୦ରେ ଅଷ୍ଟ୍ରେଲିଆରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଡିଫାଇବ୍ରୋଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୬] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ୨୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୨୫ ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୦,୦୦୦ ଡଲାର ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Defitelio Australian Prescription Medicine Decision Summary". Therapeutic Goods Administration (TGA). 31 July 2020. Archived from the original on 13 August 2020. Retrieved 16 August 2020.
↑ "Defibrotide (Defitelio) Use During Pregnancy". Drugs.com. 6 July 2020. Archived from the original on 26 November 2020. Retrieved 16 August 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Defitelio EPAR". European Medicines Agency (EMA). Archived from the original on 28 October 2020. Retrieved 16 August 2020.
↑ ^୪.୦ ^୪.୧ "Defitelio 80 mg/mL concentrate for solution for infusion - Summary of Product Characteristics". UK Electronic Medicines Compendium. 26 May 2016. Archived from the original on 31 March 2018. Retrieved 20 July 2017.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Defitelio- defibrotide sodium injection, solution". DailyMed. 30 March 2016. Archived from the original on 29 October 2020. Retrieved 16 August 2020.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Defibrotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 December 2021. Retrieved 22 December 2021.
↑ "Defitelio Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 April 2021. Retrieved 22 December 2021.

[Au2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Defitelio Australian Prescription Medicine Decision Summary". Therapeutic Goods Administration (TGA). 31 July 2020. Archived from the original on 13 August 2020. Retrieved 16 August 2020.

[Drugs.com_pregnancy-2] "Defibrotide (Defitelio) Use During Pregnancy". Drugs.com. 6 July 2020. Archived from the original on 26 November 2020. Retrieved 16 August 2020.

[EPAR2021-3] ୩.୦ ^୩.୧ ^୩.୨ "Defitelio EPAR". European Medicines Agency (EMA). Archived from the original on 28 October 2020. Retrieved 16 August 2020.

[UKlabel-4] ୪.୦ ^୪.୧ "Defitelio 80 mg/mL concentrate for solution for infusion - Summary of Product Characteristics". UK Electronic Medicines Compendium. 26 May 2016. Archived from the original on 31 March 2018. Retrieved 20 July 2017.

[PI2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Defitelio- defibrotide sodium injection, solution". DailyMed. 30 March 2016. Archived from the original on 29 October 2020. Retrieved 16 August 2020.

[AHFS2021-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ "Defibrotide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 December 2021. Retrieved 22 December 2021.

[7] "Defitelio Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 April 2021. Retrieved 22 December 2021.

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