ଟ୍ରାଇଫ୍ଲୁରିଡାଇନ

Trifluridine
Clinical data
Trade names	Viroptic; Lonsurf (+tipiracil)
Other names	α,α,α-trifluorothymidine; 5-trifluromethyl-2′-deoxyuridine; FTD5-trifluoro-2′-deoxythymidine; TFT; CF3dUrd; FTD; F3TDR; F3Thd
AHFS/Drugs.com	Monograph
License data	<abbr class="country-name" title="<nowiki>European Union</nowiki>">EU EMA: by INN[permanent dead link];
Routes of<br><br>administration	Eye drops; tablets (+tipiracil)
Drug class	Antiviral
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Canada</nowiki>">CA: ℞-only; <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only;
Pharmacokinetic data
Bioavailability	Negligible (eye drops);; ; ≥57% (by mouth)
Protein binding	>96%
Metabolism	Thymidine phosphorylase
Elimination <span class="nowrap">half-life</span>	12 minutes (eye drops);; ; 1.4–2.1 hrs (combination with tipiracil)
Excretion	Mostly via urine
Identifiers
	IUPAC name 1-[4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-(1H,3H)-pyrimidine-2,4-dione;
Chemical and physical data
Formula	C10H11F3N2O5
Molar mass	296.202 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)C=1C(=O)NC(=O)N(C=1)[C@@H]2O[C@@H]([C@@H](O)C2)CO;
	InChI InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1 ; Key:VSQQQLOSPVPRAZ-RRKCRQDMSA-N ;
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ଟ୍ରାଇଫ୍ଲୁରିଡାଇନ (ଇଂରାଜୀ ଭାଷାରେ Trifluridine), ଯାହାକୁ ଟ୍ରାଇଫ୍ଲୋରୋଥାଇମିଡାଇନ୍ ( TFT ) ମଧ୍ୟ କୁହାଯାଏ, ଏକ ଭୂତାଣୁରୋଧୀ ଔଷଧ ଯାହା ଆଖିର ହର୍ପେସ୍ ସିମ୍ପଲେକ୍ସ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ଆଖିର ଭାକସିନିଆ ସଂକ୍ରମଣ ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ ଯାହା ବସନ୍ତ ଟୀକାକରଣ ପରେ ହୋଇପାରେ ।^[୧] ଏହା ଆଖି ବୁନ୍ଦା ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।^[୧]

ଏହାର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଖିରୁ ଅଧିକ ଜଳ ବାହାରିବା, ଆଖିପତା ଫୁଲିଯିବା ଏବଂ ଆଖିର ଲାଲ ରଙ୍ଗ ହୋଇପାରେ ।^[୧] ଭୂତାଣୁ ଡିଏନଏ ସୃଷ୍ଟି ବନ୍ଦ କରି ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହେଉଥିବା ବିଶ୍ୱାସ କରାଯାଏ ।^[୧]

୧୯୮୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଟ୍ରାଇଫ୍ଲୁରିଡାଇନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ^[୨] ଏହା ଏକ ଜେନେରିକ୍ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଏବଂ ଭାଇରୋପଟିକ ବାଣିଜ୍ୟ ନାମରେ ମଧ୍ୟ ବିକ୍ରି ହୁଏ ।^[୩] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ୭.୫ ମିଲି ବିଶିଷ୍ଟ ପାତ୍ରର ମୂଲ୍ୟ ପ୍ରାୟ ୭୪ ଡଲାର ଅଟେ ।^[୩] ଏହା ମଧ୍ୟ କର୍କଟ ବିରୋଧୀ ଔଷଧ ଟ୍ରାଇଫ୍ଲୁରିଡାଇନ/ଟିପିରାସିଲର ଏକ ଉପାଦାନ | ^[୪]

ଆଧାର ସମ୍ପାଦନା

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Trifluridine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.
↑ Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-09-20.
↑ ^୩.୦ ^୩.୧ "Viroptic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 19 September 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Trifluridine Monograph for Professionals". Drugs.com. Archived from the original on 21 September 2021. Retrieved 19 September 2021.

[2] Long, Sarah S.; Pickering, Larry K.; Prober, Charles G. (2012). Principles and Practice of Pediatric Infectious Disease (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 1502. ISBN 978-1437727029. Archived from the original on 2019-12-29. Retrieved 2020-09-20.

[GX2021-3] ୩.୦ ^୩.୧ "Viroptic Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 13 October 2016. Retrieved 19 September 2021.

[BNF80-4] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 969. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

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