ଟାମସୁଲୋସିନ

ଟାମସୁଲୋସିନ
Clinical data
Pronunciation	/tæmˈsuːləsən/
Trade names	Flomax, others
AHFS/Drugs.com	monograph
MedlinePlus	a698012
data	US FDA: Tamsulosin;
Pregnancy; category	AU: B2 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
ATC code	G04CA02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	100% (by mouth)
Metabolism	Liver
Elimination half-life	9–13 hours
Excretion	76% Kidney
Identifiers
	IUPAC name (R)-5-(2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide;
CAS Number	106133-20-4 ;
PubChem CID	129211;
IUPHAR/BPS	488;
DrugBank	DB00706 ;
ChemSpider	114457 ;
UNII	G3P28OML5I;
KEGG	D08560 ;
ChEBI	CHEBI:9398 ;
ChEMBL	CHEMBL836 ;
ECHA InfoCard	100.109.780
Chemical and physical data
Formula	C20H28N2O5S
Molar mass	408.51
3D model (JSmol)	Interactive image;
	SMILES CCOc1ccccc1OCCN[C@@H](C)Cc1ccc(OC)c(c1)S(=O)(=O)N;
	InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 ; Key:DRHKJLXJIQTDTD-OAHLLOKOSA-N ;
(verify)

ଟାମସୁଲୋସିନ (ଇଂରାଜୀ ଭାଷାରେ Tamsulosin, ଏକ ବିକ୍ରୟ ନାମ ଫ୍ଲୋମାକ୍ସ/ Flomax) ଏକ ଔଷଧ ଯାହା ଲକ୍ଷଣ‌ଯୁକ୍ତ ବିନାଇନ ପ୍ରୋସ୍ଟାଟିକ ହାଇପରପ୍ଲାସିଆ (benign prostatic hyperplasia/ BPH), କ୍ରନିକ ପ୍ରୋସ୍ଟାଟାଇଟିସ (chronic prostatitis) ରୋଗମାନଙ୍କ ଚିକିତ୍ସାରେ ଦିଆଯାଏ ଓ ବୃକ୍‌କ ପଥର (kidney stones) ବାହାରିଯିବାରେ ସାହାଯ୍ୟ କରେ ।^[୨]^[୩]^[୪] ବଡ଼ ଆକାରର ବୃକ୍‌କ ପଥର ହୋଇଥିଲେ ଅଧିକ ଉପକାର ମିଳେ ।^[୪] ଏହି ଔଷଧକୁ ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ଟାମସୁଲୋସିନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ଓଜନିଆ, ମୁଣ୍ଡ ବିନ୍ଧା, ନିଦ୍ରାଳୁ ଭାବ, ଅଇ, ଝାପସା ଦୃଷ୍ଟି, ଓ ଯୌନ ସମସ୍ୟା ହୋଇପାରେ । ^[୫]^[୨] ଠିଆ ହେଲେ ମୁଣ୍ଡ ହାଲୁକା ଲାଗେ (feeling lightheaded with standing) ଓ ଆଞ୍ଜିଓଇଡିମା (angioedema) ମଧ୍ୟ ହୋଇପାରେ ।^[୫] ଟାମସୁଲୋସିନ ଏକ ଆଲଫା ବ୍ଲକର (alpha blocker) ଓ ଏହା ପ୍ରୋସ୍ଟେଟର ମାଂସପେଶୀକୁ ଶିଥିଳ କରିଦିଏ ।^[୬] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ଏକ ଆଲଫା-୧ ଆଡ୍ରେନର୍ଜିକ ରିସେପ୍ଟର (α₁ adrenergic receptor) ବ୍ଲକର । ^[୨]

ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୧୯୯୭ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଟାମସୁଲୋସିନ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୨] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଟାମସୁଲୋସିନର ଏକ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୧୦ ଡଲାରରୁ କମ୍ ।^[୭] ସନ ୨୦୧୮ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ ଆଇଏନଏଚ (NHS) ଏହାର ମୂଲ୍ୟ ବାବଦକୁ ୦.୦୪ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରେ । ^[୫] ସନ ୨୦୧୬ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଔଷଧର ୨୨ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ୩୨ତମ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିପସନ ମାନ୍ୟତା ପାଇଥିଲା । ^[୮]

ଆଧାର

↑ "Tamsulosin". Merriam-Webster Dictionary.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Tamsulosin Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.
↑ "Prostatitis". NHS (in ଇଂରାଜୀ). 19 October 2017. Retrieved 24 December 2018.
↑ ^୪.୦ ^୪.୧ Wang, RC; Smith-Bindman, R; Whitaker, E; Neilson, J; Allen, IE; Stoller, ML; Fahimi, J (7 September 2016). "Effect of Tamsulosin on Stone Passage for Ureteral Stones: A Systematic Review and Meta-analysis". Annals of Emergency Medicine. 69 (3): 353–361.e3. doi:10.1016/j.annemergmed.2016.06.044. PMID 27616037.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 767. ISBN 9780857113382.
↑ Hutchison, Lisa C.; Sleeper, Rebecca B. (2010). Fundamentals of Geriatric Pharmacotherapy: An Evidence-Based Approach (in ଇଂରାଜୀ). ASHP. p. 209. ISBN 9781585283057.
↑ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Flomax (drugs.com) – U.S. product information
Product label U.S. Food and Drug Administration (FDA)
Tamsulosin – information from USP DI Advice for the Patient

[1] "Tamsulosin". Merriam-Webster Dictionary.

[AHFS2018-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Tamsulosin Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.

[3] "Prostatitis". NHS (in ଇଂରାଜୀ). 19 October 2017. Retrieved 24 December 2018.

[Wang2016-4] ୪.୦ ^୪.୧ Wang, RC; Smith-Bindman, R; Whitaker, E; Neilson, J; Allen, IE; Stoller, ML; Fahimi, J (7 September 2016). "Effect of Tamsulosin on Stone Passage for Ureteral Stones: A Systematic Review and Meta-analysis". Annals of Emergency Medicine. 69 (3): 353–361.e3. doi:10.1016/j.annemergmed.2016.06.044. PMID 27616037.

[BNF76-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 767. ISBN 9780857113382.

[6] Hutchison, Lisa C.; Sleeper, Rebecca B. (2010). Fundamentals of Geriatric Pharmacotherapy: An Evidence-Based Approach (in ଇଂରାଜୀ). ASHP. p. 209. ISBN 9781585283057.

[7] "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.

[8] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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Clinical data


Pronunciation	/tæmˈsuːləsən/^[୧]
Trade names	Flomax, others
AHFS/Drugs.com	monograph
MedlinePlus	a698012
data	US FDA: Tamsulosin
Pregnancy category	AU: B2 US: B (No risk in non-human studies)
Routes of administration	By mouth
ATC code	G04CA02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	100% (by mouth)
Metabolism	Liver
Elimination half-life	9–13 hours
Excretion	76% Kidney
Identifiers
IUPAC name (R)-5-(2-{[2-(2-Ethoxyphenoxy)ethyl]amino}propyl)-2-methoxybenzene-1-sulfonamide
CAS Number	106133-20-4^Y
PubChem CID	129211
IUPHAR/BPS	488
DrugBank	DB00706^Y
ChemSpider	114457^Y
UNII	G3P28OML5I
KEGG	D08560^Y
ChEBI	CHEBI:9398^Y
ChEMBL	CHEMBL836^Y
ECHA InfoCard	100.109.780
Chemical and physical data
Formula	C₂₀H₂₈N₂O₅S
Molar mass	408.51
3D model (JSmol)	Interactive image
SMILES CCOc1ccccc1OCCN[C@@H](C)Cc1ccc(OC)c(c1)S(=O)(=O)N
InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1^Y Key:DRHKJLXJIQTDTD-OAHLLOKOSA-N^Y
(verify)