ଟାଫାମିଡିସ

ଟାଫାମିଡିସ
Clinical data
Trade names	Vyndaqel, Vyndamax, others
Synonyms	Tafamidis meglumine
AHFS/Drugs.com	monograph
data	US DailyMed: Tafamidis;
Pregnancy; category	AU: D ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Identifiers
	IUPAC name 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid;
ECHA InfoCard	100.246.079
Chemical and physical data
Formula	C14H7Cl2NO3
Molar mass	୩୦୮.୧୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)c3ccc1nc(oc1c3)-c2cc(Cl)cc(Cl)c2;
	InChI InChI=1S/C14H7Cl2NO3/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13/h1-6H,(H,18,19) ; Key:TXEIIPDJKFWEEC-UHFFFAOYSA-N ;
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ଟାଫାମିଡିସ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏହାର ଏକ ବିକ୍ରୟ ନାମ ଭିଣ୍ଡାକେଲ୍, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଟ୍ରାନ୍ସଥାଇରେଟିନ-ମାଧ୍ୟମ ଆମିଲଏଡୋସିସ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୭] ଯକୃତ ପ୍ରତିରୋପଣ ପରେ ଏହାକୁ ବନ୍ଦ କରାଯାଇପାରିବ ।^[୭]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ତରଳ ଝାଡ଼ା ଏବଂ ସଂକ୍ରମଣ ହୋଇପାରେ ।^[୭] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ପହଞ୍ଚାଇଥାଏ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୮] ଏହା ପ୍ରୋଟିନ୍ ଟ୍ରାନ୍ସଥାଇରେଟିନ ସ୍ଥିର କରିବା ଯୋଗୁ ଆମିଲଏଡ୍ ନିରୂପଣ ବା ଫର୍ମୁଲେସନ୍ କମିଯାଏ ।^[୩]

୨୦୧୧ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଟାଫାମିଡିସ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୬] ଏହି ଔଷଧ ପିଛା ଯୁକ୍ତରାଜ୍ୟରେ ଦିନକୁ ୨୦ ମିଗ୍ରା ହିସାବରେ ଏକ ମାସରେ ୧୦,୭୦୦ ଖର୍ଚ୍ଚ ହୁଏ ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ଔଷଧର ମୂଲ୍ୟ ୪,୯୦୦ ଡଲାର ଅଟେ ।^[୯]

ଆଧାର ସମ୍ପାଦନା

↑ ^୧.୦ ^୧.୧ "Vyndamax and Vyndaqel Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 17 July 2020. Archived from the original on 29 August 2021. Retrieved 16 August 2020.
↑ "Tafamidis Use During Pregnancy". Drugs.com. 6 September 2019. Archived from the original on 11 July 2021. Retrieved 16 August 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Vyndaqel EPAR". European Medicines Agency (EMA). 16 October 2019. Archived from the original on 25 November 2019. Retrieved 24 November 2019.
↑ "Vyndaqel 20 mg soft capsules - Summary of Product Characteristics". Electronic Medicines Compendium. Archived from the original on 2 April 2018. Retrieved 2 April 2018.
↑ "Vyndaqel- tafamidis meglumine capsule, liquid filled Vyndamax- tafamidis capsule, liquid filled". DailyMed. 30 August 2019. Archived from the original on 1 April 2020. Retrieved 24 November 2019.
↑ ^୬.୦ ^୬.୧ "Tafamidis Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 July 2021. Retrieved 7 August 2021.
↑ ^୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 428. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Tafamidis Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 16 September 2021.
↑ "Vyndaqel Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 September 2021.

[Vyndamax_and_Vyndaqel_APMDS-1] ୧.୦ ^୧.୧ "Vyndamax and Vyndaqel Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 17 July 2020. Archived from the original on 29 August 2021. Retrieved 16 August 2020.

[Drugs.com_pregnancy-2] "Tafamidis Use During Pregnancy". Drugs.com. 6 September 2019. Archived from the original on 11 July 2021. Retrieved 16 August 2020.

[EPAR2021-3] ୩.୦ ^୩.୧ ^୩.୨ "Vyndaqel EPAR". European Medicines Agency (EMA). 16 October 2019. Archived from the original on 25 November 2019. Retrieved 24 November 2019.

[UKlabel-4] "Vyndaqel 20 mg soft capsules - Summary of Product Characteristics". Electronic Medicines Compendium. Archived from the original on 2 April 2018. Retrieved 2 April 2018.

[Vyndaqel_and_Vyndamax_label-5] "Vyndaqel- tafamidis meglumine capsule, liquid filled Vyndamax- tafamidis capsule, liquid filled". DailyMed. 30 August 2019. Archived from the original on 1 April 2020. Retrieved 24 November 2019.

[AHFS2021-6] ୬.୦ ^୬.୧ "Tafamidis Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 July 2021. Retrieved 7 August 2021.

[BNF80-7] ୭.୦ ^୭.୧ ^୭.୨ ^୭.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 428. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[8] "Tafamidis Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 July 2021. Retrieved 16 September 2021.

[9] "Vyndaqel Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 16 September 2021.

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