ଜାଇଲୋମେଟାଜୋଲିନ

ଜାଇଲୋମେଟାଜୋଲିନ
Clinical data
Pronunciation	/ˌzaɪloʊmɛˈtɑːzoʊliːn/ ZY-loh-met-AH-zoh-leen
Trade names	Otrivin, Otrivine, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	C;
Dependence; liability	moderate
Routes of; administration	intranasal (spray or drops)
ATC code	R01AA07 (WHO) S01GA03;
Legal status
Legal status	OTC;
Pharmacokinetic data
Elimination half-life	>10 seconds
Excretion	Urinary
Identifiers
	IUPAC name 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-; 4,5-dihydro-1H-imidazole;
CAS Number	526-36-3 ;
PubChem CID	5709;
IUPHAR/BPS	517;
DrugBank	DB06694 ;
ChemSpider	5507 ;
UNII	WPY40FTH8K;
KEGG	D08684 ;
ChEMBL	CHEMBL312448 ;
ECHA InfoCard	100.007.629
Chemical and physical data
Formula	C16H24N2
Molar mass	244.37516 g/mol
3D model (JSmol)	Interactive image;
	SMILES N\1=C(\NCC/1)Cc2c(cc(cc2C)C(C)(C)C)C;
	InChI InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18) ; Key:HUCJFAOMUPXHDK-UHFFFAOYSA-N ;
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ଜାଇଲୋମେଟାଜୋଲିନ (ଇଂରାଜୀରେ Xylometazoline, ବା xylomethazoline) ଏକ ଔଷଧ ଯାହା ରକ୍ତସଙ୍କୁଳ ନାସା (nasal congestion), ଆଲର୍ଜିକ ରାଇନାଇଟିସ allergic rhinitis ଓ ସାଇନୁସାଇଟିସ sinusitis ଆଦି ରୋଗମାନଙ୍କ ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୧] ସାତ ଦିନରୁ ଅଧିକ ଏହି ଔଷଧ ଦେବାକୁ ସୁପାରିସ କରାଯାଏନାହିଁ ।^[୨] ତିନି ମାସ ବୟସ ତଳକୁ ଦେବାକୁ ମନା ଥିଲେ ମଧ୍ୟ ୬ ବର୍ଷ ତଳକୁ ଦେବାକୁ ମଧ୍ୟ ଅନେକ ସୁପାରିସ କରନ୍ତିନାହିଁ ।^[୨]^[୩] ଏହା ନାକ (nose) ଭିତରେ ପକାଯାଏ ବା ନାକ ଭିତରକୁ ସ୍ପ୍ରେ କରାଯାଏ ।^[୨]

ଜାଇଲୋମେଟାଜୋଲିନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହେଲେ ନିଦ୍ରା ସମସ୍ୟା, ଅଇ ଓ ମୁଣ୍ଡବଥା ଆଦି ଲକ୍ଷଣ ଦେଖାଯାଏ ।^[୧]^[୨] ଦୀର୍ଘକାଳୀନ ବ୍ୟବ‌ହାର ପରେ ବନ୍ଦ କରିଦେଲେ ରାଇନାଇଟିସ ମେଡିକାମେଣ୍ଟୋସା (rhinitis medicamentosa) ରୋଗ ସମ୍ଭାବନା ଥିବାରୁ ବେଶୀଦିନ ପର୍ଯ୍ୟନ୍ତ ଦିଆଯାଏ ନାହିଁ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ଏହା ଦିଆଯାଏନାହିଁ ।^[୧] ଜାଇଲୋମେଟାଜୋଲିନ ଏକ ଡିକଞ୍ଜେସ୍ଟାଣ୍ଟ (decongestant) ଓ ଆଲଫା-ଆଡ୍ରେନର୍ଜିକ (alpha-adrenergic agonist) ଶ୍ରେଣୀର ଔଷଧ ।^[୪]^[୫]

ସନ ୧୯୫୬ରେ ଜାଇଲୋମେଟାଜୋଲିନ ପେଟେଣ୍ଟ ହେବାପରେ ସନ ୧୯୫୯ରେ ଏହାର ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ଆରମ୍ଭ ହେଲା ।^[୬] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୩] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୨] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ଦଶ ମି:ଲି: ବୋତଲର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୦.୭୫ ଆମେରିକୀୟ ଡଲାର ।^[୭] ଇଂଲଣ୍ଡରେ ଏହି ଡୋଜର ମୂଲ୍ୟ ପ୍ରାୟ ୨.୧୦ ପାଉଣ୍ଡ । ^[୨]

ଆଧାର ସମ୍ପାଦନା

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Otrivine Adult Measured Dose Sinusitis Spray - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 13 April 2016. Retrieved 28 December 2016.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 786. ISBN 9780857111562.
↑ ^୩.୦ ^୩.୧ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ ^୪.୦ ^୪.୧ Graf, P (1997). "Rhinitis medicamentosa: aspects of pathophysiology and treatment". Allergy. 52 (40 Suppl): 28–34. PMID 9353558.
↑ "Xylometazoline nasal medical facts from Drugs.com". www.drugs.com. Retrieved 28 December 2016.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 552. ISBN 9783527607495.
↑ "Xylometazoline". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[UK2016-1] ୧.୦ ^୧.୧ ^୧.୨ "Otrivine Adult Measured Dose Sinusitis Spray - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 13 April 2016. Retrieved 28 December 2016.

[BNF69-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 786. ISBN 9780857111562.

[WHO19th-3] ୩.୦ ^୩.୧ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[Gra1997-4] ୪.୦ ^୪.୧ Graf, P (1997). "Rhinitis medicamentosa: aspects of pathophysiology and treatment". Allergy. 52 (40 Suppl): 28–34. PMID 9353558.

[MTM2016-5] "Xylometazoline nasal medical facts from Drugs.com". www.drugs.com. Retrieved 28 December 2016.

[Fis2006-6] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 552. ISBN 9783527607495.

[ERC2014-7] "Xylometazoline". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

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Clinical data

Pronunciation	/ˌzaɪloʊmɛˈtɑːzoʊliːn/ ZY-loh-met-AH-zoh-leen
Trade names	Otrivin, Otrivine, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	C
Dependence liability	moderate
Routes of administration	intranasal (spray or drops)
ATC code	R01AA07 (WHO) S01GA03
Legal status
Legal status	OTC
Pharmacokinetic data
Elimination half-life	>10 seconds
Excretion	Urinary
Identifiers
IUPAC name 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]- 4,5-dihydro-1H-imidazole
CAS Number	526-36-3^N
PubChem CID	5709
IUPHAR/BPS	517
DrugBank	DB06694^Y
ChemSpider	5507^Y
UNII	WPY40FTH8K
KEGG	D08684^Y
ChEMBL	CHEMBL312448^Y
ECHA InfoCard	100.007.629
Chemical and physical data
Formula	C₁₆H₂₄N₂
Molar mass	244.37516 g/mol
3D model (JSmol)	Interactive image
SMILES N\1=C(\NCC/1)Cc2c(cc(cc2C)C(C)(C)C)C
InChI InChI=1S/C16H24N2/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15/h8-9H,6-7,10H2,1-5H3,(H,17,18)^Y Key:HUCJFAOMUPXHDK-UHFFFAOYSA-N^Y
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