ଗ୍ଲାଇକ୍ଲାଜାଇଡ

ଗ୍ଲାଇକ୍ଲାଜାଇଡ
Clinical data
Trade names	Diamicron, others
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: C ; ;
ATC code	A10BB09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ;
Pharmacokinetic data
Elimination half-life	10.4 hours
Identifiers
	IUPAC name N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide;
CAS Number	21187-98-4 ;
PubChem CID	3475;
DrugBank	DB01120 ;
ChemSpider	3356 ;
UNII	G4PX8C4HKV;
KEGG	D01599 ;
ChEBI	CHEBI:31654 ;
ChEMBL	CHEMBL427216 ;
ECHA InfoCard	100.040.221
Chemical and physical data
Formula	C15H21N3O3S
Molar mass	323.412 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1ccc(cc1)C)NC(=O)NN3CC2CCCC2C3;
	InChI InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19) ; Key:BOVGTQGAOIONJV-UHFFFAOYSA-N ;
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ଗ୍ଲାଇକ୍ଲାଜାଇଡ (ଇଂରାଜୀ ଭାଷାରେ Gliclazide, ବିକ୍ରୟ ନାମ ଡାଏମିକ୍ରନ/Diamicron) ଏକ ମଧୁମେହ-ବିରୋଧୀ ଔଷଧ (anti-diabetic medication) ଯାହା ମଧୁମେହ ଟାଇପ ୨ ରୋଗର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୨] ଖାଦ୍ୟ ପରିବର୍ତ୍ତନ, ବ୍ୟାୟାମ ଓ ଓଜନ ହ୍ରାସ ଇତ୍ୟାଦି ଚିକିତ୍ସା ଫଳପ୍ରଦ ନହେଲେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୩] ଏହାକୁ ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ଗ୍ଲାଇକ୍ଲାଜାଇଡର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ରକ୍ତ ଶର୍କରା (low blood sugar), ବାନ୍ତି, ପେଟ ଯନ୍ତ୍ରଣା (abdominal pain), ରାସ ଓ ଯକୃତ ସମସ୍ୟା (liver problems) ଦେଖାଯାଇ ପାରେ । ବୃକ୍‌କ ସମସ୍ୟା (kidney problems), ଯକୃତ ସମସ୍ୟା ବା ଗର୍ଭାବସ୍ଥାରେ ଏହି ଔଷଧ ଦେବାକୁ ସୁପାରିସ କରାଯାଏନାହିଁ । ^[୨]^[୩] ଏହା ଏକ ସଲଫୋନିଲୁରିଆ (sulfonylurea) ଶ୍ରେଣୀର ଔଷଧ । ଏହି ଔଷଧଦ୍ୱାରା ଇନସୁଲିନ (insulin) କ୍ଷରଣ ବୃଦ୍ଧି ପାଏ ।^[୨]

ସନ୧୯୬୬ରେ ଗ୍ଲାଇକ୍ଲାଜାଇଡ ପେଟେଣ୍ଟ ହେବାପରେ ସନ ୧୯୭୨ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା । ^[୪] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ମାସର ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୨.୪୬ରୁ ୩.୯୨ ଆମେରିକୀୟ ଡଲାର ।^[୬] ଇଂଲଣ୍ଡରେ ଏହି ଔଷଧର ମୂଲ୍ୟ ୨.୧୨ ପାଉଣ୍ଡ ।^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହା ମିଳେନାହିଁ ।^[୭]

ଆଧାର

↑ "Gliclazide - Drugs.com". www.drugs.com. Retrieved 27 December 2016.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 474. ISBN 9780857111562.
↑ ^୩.୦ ^୩.୧ "Bilxona 30mg Modified-release Tablets - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 29 August 2016. Archived from the original on 27 December 2016. Retrieved 27 December 2016.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 449. ISBN 9783527607495.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Gliclazide". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ "Gliclazide Advanced Patient Information - Drugs.com". www.drugs.com. Retrieved 27 December 2016.

[1] "Gliclazide - Drugs.com". www.drugs.com. Retrieved 27 December 2016.

[BNF69-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 474. ISBN 9780857111562.

[UK2016-3] ୩.୦ ^୩.୧ "Bilxona 30mg Modified-release Tablets - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 29 August 2016. Archived from the original on 27 December 2016. Retrieved 27 December 2016.

[Fis2006-4] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 449. ISBN 9783527607495.

[WHO19th-5] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-6] "Gliclazide". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[7] "Gliclazide Advanced Patient Information - Drugs.com". www.drugs.com. Retrieved 27 December 2016.

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Clinical data


Trade names	Diamicron, others^[୧]
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: C
ATC code	A10BB09 (WHO)
Legal status
Legal status	AU: S4 (Prescription only)
Pharmacokinetic data
Elimination half-life	10.4 hours
Identifiers
IUPAC name N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide
CAS Number	21187-98-4^Y
PubChem CID	3475
DrugBank	DB01120^Y
ChemSpider	3356^Y
UNII	G4PX8C4HKV
KEGG	D01599^Y
ChEBI	CHEBI:31654^Y
ChEMBL	CHEMBL427216^Y
ECHA InfoCard	100.040.221
Chemical and physical data
Formula	C₁₅H₂₁N₃O₃S
Molar mass	323.412 g/mol
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c1ccc(cc1)C)NC(=O)NN3CC2CCCC2C3
InChI InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)^Y Key:BOVGTQGAOIONJV-UHFFFAOYSA-N^Y
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