ଗାଲିଅମ (୬୮ ଜିଏ) ଗୋଜେଟୋଟାଇଡ

ଗାଲିଅମ (୬୮ ଜିଏ) ଗୋଜେଟୋଟାଇଡ
Clinical data
Trade names	Illuccix, Locametz
Other names	Gallium 68 PSMA-11, Gallium Ga 68 gozetotide (USAN <abbr title="<nowiki>United States</nowiki>">US)
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	<abbr class="country-name" title="<nowiki>United States</nowiki>">US DailyMed: Gozetotide;
Pregnancy; </nowiki>; </nowiki>category	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: Exempt;
Routes of; </nowiki>; </nowiki>administration	Intravenous
Drug class	Radioactive diagnostic agent
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: S4 (Prescription only); <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only;
Pharmacokinetic data
Excretion	Urine
Identifiers
	IUPAC name 2-[[5-[3-[[6-[[(5S)-5-carboxy-5-[[(1S)-1,3-dicarboxypropyl]carbamoylamino]pentyl]amino]-6-oxohexyl]amino]-3-oxopropyl]-2-oxidophenyl]methyl-[2-[[5-(2-carboxyethyl)-2-oxidophenyl]methyl-(carboxylatomethyl)amino]ethyl]amino]acetate;gallium-68(3+);hydron;
Chemical and physical data
3D model (JSmol)	Interactive image;
	SMILES [H+].C1=CC(=C(C=C1CCC(=O)NCCCCCC(=O)NCCCC[C@@H](C(=O)O)NC(=O)N[C@@H](CCC(=O)O)C(=O)O)CN(CCN(CC2=C(C=CC(=C2)CCC(=O)O)[O-])CC(=O)[O-])CC(=O)[O-])[O-].[68Ga+3];
	InChI InChI=1S/C44H62N6O17.Ga/c51-34-13-8-28(22-30(34)24-49(26-40(59)60)20-21-50(27-41(61)62)25-31-23-29(9-14-35(31)52)11-16-38(55)56)10-15-37(54)46-18-4-1-2-7-36(53)45-19-5-3-6-32(42(63)64)47-44(67)48-33(43(65)66)12-17-39(57)58;/h8-9,13-14,22-23,32-33,51-52H,1-7,10-12,15-21,24-27H2,(H,45,53)(H,46,54)(H,55,56)(H,57,58)(H,59,60)(H,61,62)(H,63,64)(H,65,66)(H2,47,48,67);/q;+3/p-3/t32-,33-;/m0./s1/i;1-2; Key:AEBYHKKMCWUMKX-LNTZDJBBSA-K;

ଗାଲିଅମ (^୬୮ ଜିଏ) ଗୋଜେଟୋଟାଇଡ (ଇଂରାଜୀ ଭାଷାରେ Gallium (⁶⁸Ga) gozetotide), ଇଲୁକିକ୍ସ ବ୍ରାଣ୍ଡ ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ରେଡିଓଆକ୍ଟିଭ ନିଦାନ‌କାରୀ କର୍ମ ନିର୍ବାହକ ଯାହା ପୋଜିଟ୍ରନ୍ ଏମିସନ୍ ଟୋମୋଗ୍ରାଫି (PET) ଦ୍ୱାରା ପ୍ରୋଷ୍ଟେଟ କର୍କଟର ଚିତ୍ର ଉତ୍ତୋଳନ କରାଯାଏ । ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ପ୍ରୋଷ୍ଟେଟ୍-ନିର୍ଦ୍ଦିଷ୍ଟ ମେମ୍ବ୍ରେନ୍ ଆଣ୍ଟିଜେନ୍ (PSMA) ଯୁକ୍ତାତ୍ମକ ଥିଲେ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ତରଳ ଝାଡ଼ା ଏବଂ ମୁଣ୍ଡ ବୁଲାଇ ପାରେ । ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବିକିରଣ ଏକ୍ସପୋଜର ହୋଇପାରେ ।^[୨] ଏହା ପ୍ରୋଷ୍ଟେଟ-ନିର୍ଦ୍ଦିଷ୍ଟ ମେମ୍ବ୍ରେନ୍ ଆଣ୍ଟିଜେନ୍ (PSMA) ସହିତ ^୬୮</nowiki>ଗ୍ୟା ସ‌ହିତ ସଂଯୁକ୍ତ ହୋଇ ଲିଗାଣ୍ଡ୍, ଗ୍ଲୁ-ୟୁରିଆ-ଲାଇସ୍ (ଆକ୍ସ) କୁ ଶରବ୍ୟ କରେ ।^[୬]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଗାଲିୟମ୍ (^୬୮ଜିଏ) ଗୋଜେଟେଟୋଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା । ୨୦୨୨ ସୁଦ୍ଧା ଏହାକୁ ଅନୁମୋଦନ ପାଇଁ ସୁପାରିଶ କରାଯାଇଛି, କିନ୍ତୁ ଏପର୍ଯ୍ୟନ୍ତ ୟୁରୋପରେ ଅନୁମୋଦିତ ହୋଇନାହିଁ ।^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୨ ସୁଦ୍ଧା ୨୫ ucg ର ମୂଲ୍ୟ ୨୦୦୦ ପାଉଣ୍ଡ ଅଟେ ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "AusPAR: Glu-urea-Lys(ahx)-hbed-CC". Therapeutic Goods Administration (TGA). 27 June 2022. Retrieved 17 July 2022.{{cite web}}: CS1 maint: url-status (link)
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Gallium GA-68 PSMA-11- gallium ga-68 gozetotide injection, solution".
↑ "Gallium GA-68 PSMA-11- gallium ga-68 gozetotide injection, solution".
↑ "Illuccix- kit for the preparation of gallium ga 68 gozetotide injection kit".
↑ "Locametz- kit for the preparation of gallium ga 68 gozetotide injection, powder, lyophilized, for solution".
↑ "https://www.cancer.gov/publications/dictionaries/cancer-drug/def/gallium-ga-68-gozetotide?redirect=true". www.cancer.gov (in ଇଂରାଜୀ). 2 February 2011. Archived from the original on 18 November 2021. Retrieved 3 November 2022. {{cite web}}: External link in |title= (help)
↑ ^୭.୦ ^୭.୧ "Gozetotide". SPS - Specialist Pharmacy Service. 16 August 2022. Archived from the original on 3 November 2022. Retrieved 3 November 2022.

[AusPAR:_Glu-urea-Lys(ahx)-hbed-CC-1] ୧.୦ ^୧.୧ "AusPAR: Glu-urea-Lys(ahx)-hbed-CC". Therapeutic Goods Administration (TGA). 27 June 2022. Retrieved 17 July 2022.{{cite web}}: CS1 maint: url-status (link)

[PI2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Gallium GA-68 PSMA-11- gallium ga-68 gozetotide injection, solution".

[3] "Gallium GA-68 PSMA-11- gallium ga-68 gozetotide injection, solution".

[Illuccix_FDA_label-4] "Illuccix- kit for the preparation of gallium ga 68 gozetotide injection kit".

[Locametz_FDA_label-5] "Locametz- kit for the preparation of gallium ga 68 gozetotide injection, powder, lyophilized, for solution".

[NCI2022-6] "https://www.cancer.gov/publications/dictionaries/cancer-drug/def/gallium-ga-68-gozetotide?redirect=true". www.cancer.gov (in ଇଂରାଜୀ). 2 February 2011. Archived from the original on 18 November 2021. Retrieved 3 November 2022. {{cite web}}: External link in |title= (help)

[SPS2022-7] ୭.୦ ^୭.୧ "Gozetotide". SPS - Specialist Pharmacy Service. 16 August 2022. Archived from the original on 3 November 2022. Retrieved 3 November 2022.

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