କ୍ଲୋରଜୋକ୍ସାଜୋନ

କ୍ଲୋରଜୋକ୍ସାଜୋନ
Clinical data
Pronunciation	klor zox' a zone
Trade names	Lorzone, Paraflex, Muscol, others
AHFS/Drugs.com	monograph
MedlinePlus	a682577
data	US DailyMed: Chlorzoxazone;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	13–18%
Metabolism	Liver
Onset of action	With 1 hr
Elimination half-life	1.1 hr
Duration of action	Up to 4 hr
Excretion	Urine (<1%)
Identifiers
	IUPAC name 5-chloro-3H-benzooxazol-2-one;
ECHA InfoCard	100.002.186
Chemical and physical data
Formula	C7H4ClNO2
Molar mass	୧୬୯.୫୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2cc1c(OC(=O)N1)cc2;
	InChI InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10) ; Key:TZFWDZFKRBELIQ-UHFFFAOYSA-N ;
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କ୍ଲୋରଜୋକ୍ସାଜୋନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଲୋରଜୋନ, ହେଉଛି ଏକ ମାଂସପେଶୀ ଶିଥିଳକାରୀ ଔଷଧ ଯାହା କଟି ଯନ୍ତ୍ରଣା କମେଇବାକୁ ଏବଂ ମାଂସପେଶୀ ସ୍ପାଜ୍ମର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହାର ଚିକିତ୍ସାରେ ମଧ୍ୟମ ଧରଣର ଉପକାର ମିଳେ ।^[୧] ସେରେବ୍ରାଲ ପାଲ୍‌ସି ଭଳି ସ୍ନାୟୁଗତ ସମସ୍ୟା ପାଇଁ ଏହା ଉପଯୋଗୀ ନୁହେଁ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧] ଏହାର ପ୍ରଭାବ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୋଇ ୪ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବୁଲାଇବା, ନିଦ୍ରାହୀନତା, ମୁଣ୍ଡବିନ୍ଧା ଏବଂ କମ୍ପନ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା ଏବଂ ଆଞ୍ଜିଓଇଡିମା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୧]^[୪] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୪] ଏହା ମେରୁଦଣ୍ଡ ଏବଂ ମସ୍ତିଷ୍କ ସ୍ତରରେ କାମ କରେ ।^[୪]

୧୯୫୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ କ୍ଲୋରଜକ୍ସାଜୋନକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୫୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୬୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୨ ସୁଦ୍ଧା ପ୍ରାୟ ୧୮ ଡଲାର ଅଟେ ।^[୫] ୨୦୧୭ ସୁଦ୍ଧା ଏହା ବହୁଳ ଭାବରେ ବ୍ୟବହୃତ ହୋଇଛି ।^[୧]

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ ^୧.୮ "Chlorzoxazone". Archived from the original on 8 May 2021. Retrieved 4 January 2022.
↑ "Parafon DSC- chlorzoxazone tablet". DailyMed. 9 February 2010. Archived from the original on 16 March 2021. Retrieved 5 November 2020.
↑ "Lorzone- chlorzoxazone tablet". DailyMed. 21 June 2019. Archived from the original on 12 November 2020. Retrieved 5 November 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ ^୪.୬ "Chlorzoxazone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 4 January 2022.
↑ "Chlorzoxazone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 4 January 2022.

[Liv2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ ^୧.୭ ^୧.୮ "Chlorzoxazone". Archived from the original on 8 May 2021. Retrieved 4 January 2022.

[2] "Parafon DSC- chlorzoxazone tablet". DailyMed. 9 February 2010. Archived from the original on 16 March 2021. Retrieved 5 November 2020.

[3] "Lorzone- chlorzoxazone tablet". DailyMed. 21 June 2019. Archived from the original on 12 November 2020. Retrieved 5 November 2020.

[AHFS2022-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ ^୪.୬ "Chlorzoxazone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 4 January 2022.

[5] "Chlorzoxazone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 5 November 2016. Retrieved 4 January 2022.

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[୨]

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Clinical data

Pronunciation	klor zox' a zone^[୧]
Trade names	Lorzone, Paraflex, Muscol, others
AHFS/Drugs.com	monograph
MedlinePlus	a682577
data	US DailyMed: Chlorzoxazone
Pregnancy category	US: N (Not classified yet)
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only ^[୨]^[୩]
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	13–18%
Metabolism	Liver
Onset of action	With 1 hr^[୪]
Elimination half-life	1.1 hr
Duration of action	Up to 4 hr^[୪]
Excretion	Urine (<1%)
Identifiers
IUPAC name 5-chloro-3H-benzooxazol-2-one
ECHA InfoCard	100.002.186
Chemical and physical data
Formula	C₇H₄ClNO₂
Molar mass	୧୬୯.୫୬ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc2cc1c(OC(=O)N1)cc2
InChI InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)^Y Key:TZFWDZFKRBELIQ-UHFFFAOYSA-N^Y
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