କ୍ଲୋନାଜେପାମ୍

କ୍ଲୋନାଜେପାମ୍
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682279
data	US FDA: Clonazepam;
Pregnancy; category	AU: C ; US: D (Evidence of risk) ; ;
Dependence; liability	Moderate
Routes of; administration	Oral, I.M., I.V, sublingual
ATC code	N03AE01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule IV ; DE: Anlage III (Prescription only) ; UK: Class C ; US: Schedule IV ; India: schedule H;
Pharmacokinetic data
Bioavailability	90%
Protein binding	~85%
Metabolism	Liver CYP3A4
Onset of action	Within an hour
Elimination half-life	18–50 hours
Duration of action	6 to 12 hr
Excretion	Kidney
Identifiers
	IUPAC name 5-(2-Chlorophenyl)-7-nitro-2,3-dihydro-1,4-benzodiazepin-2-one;
CAS Number	1622-61-3 ;
PubChem CID	2802;
IUPHAR/BPS	6963;
DrugBank	DB01068 ;
ChemSpider	2700 ;
UNII	5PE9FDE8GB;
KEGG	D00280 ;
ChEBI	CHEBI:3756 ;
ChEMBL	CHEMBL452 ;
ECHA InfoCard	100.015.088
Chemical and physical data
Formula	C15H10ClN3O3
Molar mass	315.715
3D model (JSmol)	Interactive image;
	SMILES [O-][N+](C1=CC2=C(C=C1)NC(CN=C2C3=CC=CC=C3Cl)=O)=O;
	InChI InChI=1S/C15H10ClN3O3/c16-12-4-2-1-3-10(12)15-11-7-9(19(21)22)5-6-13(11)18-14(20)8-17-15/h1-7H,8H2,(H,18,20) ; Key:DGBIGWXXNGSACT-UHFFFAOYSA-N ;
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କ୍ଲୋରାଜୋଲାମ୍, କ୍ଲୋନାଜୋଲାମ୍ ସହିତ ଭ୍ରମିତ ହେବେନି !

କ୍ଲୋନାଜେପାମ, ବା ବିକ୍ରିହେଉଥିବା ବ୍ରାଣ୍ଡ ନାମ କ୍ଲୋନୋପିନ ଏକ ଔଷଧ ଯାହା କେତେକ ରୋଗର ପ୍ରତିରୋଧ ଓ ଚିକିତ୍ସା ନିମନ୍ତେ ବ୍ୟବ‌ହାର କରାଯାଏ ଯଥା: - ବାତ/ସିଜର(seizures), ପ୍ୟାନିକ ଡିଜଅର୍ଡ଼ର ଓ ମୁଭମେଣ୍ଟ ଡିଜଅର୍ଡ଼ର ଯେପରିକି ଆକାଥିସିଆ । ^[୩] ଏହା ଏକ ପ୍ରକାର ବେଞ୍ଜୋଡାଏଜେପିନ ଔଷଧ ଯାହା ଟ୍ରାଙ୍କୁଇଲାଇଜର କାମ କରେ । ଏହା ପାଟି ବାଟେ ଦିଆଯାଏ । ^[୩] ଏହାର ପ୍ରଭାବ ଏକ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ଓ ୬ରୁ ୧୨ ଘଣ୍ଟା ପର୍ଯ୍ୟନ୍ତି ରହେ । ^[୨]

ଏହି ଔଷଧର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା:- ନିଦ୍ରାବେଶ, ସମନ୍ୱୟ ଅଭାବ ଓ ଉତ୍ତେଜନା । ଏହା ଆତ୍ମହତ୍ୟା ପ୍ରବଣତା ବୃଦ୍ଧି କରାଏ । ବେଞ୍ଜୋଡାଏଜେପିନର ଦୀର୍ଘକାଳୀନ ପ୍ରଭାବ ଯୋଗୁ ଡ୍ରଗ ଇନ୍‌ଟୋଲେରାନ୍ସ, ବେଞ୍ଜୋଡାଏଜେପିନ ଡିପେଣ୍ଡେନ୍ସ ଓ ଡ୍ରଗ ନେବା ବନ୍ଦକଲେ ଉଇଥଡ୍ରୟାଲ ଲକ୍ଷଣ ଦେଖାଯାଏ ।^[୩]ଚାରି ସପ୍ତାହରୁ ଅଧିକ କାଳ ଏହା ନେଲେ ଡିପେଣ୍ଡେନ୍ସ ହୁଏ । ^[୪] ଗର୍ଭାବସ୍ଥାରେ ନେଲେ ଶିଶୁକୁ ବିପଦ ହୋଇପାରେ । ^[୩] ଏହା ଗାବା ରେସେପ୍ଟର ସ‌ହିତ ସଂଯୁକ୍ତ ହୋଇ ଗାବା ପ୍ରଭାବ ବୃଦ୍ଧି କରାଏ । ^[୪]

କ୍ଳୋନାଜେପାମ ଏସଏନ ୧୯୬୪ରେ ପ୍ରଥମେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଓ ଆମେରିକାରେ ସନ ୧୯୭୫ରେ ବିକ୍ରୟ ଆରମ୍ଭ କରାଯାଇଥିଲା ।^[୫] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ^[୩] ଏହାର ହୋଲସେଲ ମୂଲ୍ୟ ପିଲ ପିଛା 0.0୧ରୁ 0.0୭ ଆମେରୋକୀୟ ଡଲାର ।^[୬] ଆମେରିକାରେ ଏହାର ପ୍ରତି ପିଲର ମୂଲ୍ୟ ପ୍ରାୟ 0.୪0 ଆମେରିକୀୟ ଡଲାର ।^[୩] ପୃଥିବୀର ଅନେକ ସ୍ଥାନରେ ଏହା ମନୋରଞ୍ଜନ‌କାରୀ ଔଷଧ ହିସାବରେ ବ୍ୟବହାର କରାଯାଏ ।^[୭]^[୮]

ଆଧାର

↑ Saunders Nursing Drug Handbook 2014
↑ ^୨.୦ ^୨.୧ ^୨.୨ Cooper, edited by Grant (2007). Therapeutic uses of botulinum toxin. Totowa, N.J.: Humana Press. p. 214. ISBN 9781597452472. {{cite book}}: |first1= has generic name (help)
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Clonazepam". The American Society of Health-System Pharmacists. Retrieved Aug 15, 2015.
↑ ^୪.୦ ^୪.୧ Riss, J.; Cloyd, J.; Gates, J.; Collins, S. (Aug 2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics". Acta Neurol Scand. 118 (2): 69–86. doi:10.1111/j.1600-0404.2008.01004.x. PMID 18384456. Archived from the original (PDF) on 2020-04-04. Retrieved 2015-10-26.
↑ Shorter, Edward (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 9780190292010.
↑ "Clonazepam". International Drug Price Indicator Guide. Archived from the original on 30 October 2015. Retrieved 15 August 2015.
↑ Martino, edited by Davide; Cavanna, Andrea E. (2013). Advances in the neurochemistry and neuropharmacology of Tourette Syndrome. Burlington: Elsevier Science. p. 357. ISBN 9780124115613. In several countries, presciption and use is now severely limited due to abusive recreational use of clonazepam. {{cite book}}: |first1= has generic name (help)
↑ Fisher, Gary L. (2009). Encyclopedia of substance abuse prevention, treatment, & recovery. Los Angeles: SAGE. p. 100. ISBN 9781412950848. frequently abused

[1] Saunders Nursing Drug Handbook 2014

[Coop2007-2] ୨.୦ ^୨.୧ ^୨.୨ Cooper, edited by Grant (2007). Therapeutic uses of botulinum toxin. Totowa, N.J.: Humana Press. p. 214. ISBN 9781597452472. {{cite book}}: |first1= has generic name (help)

[AHFS2015-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Clonazepam". The American Society of Health-System Pharmacists. Retrieved Aug 15, 2015.

[Riss-2008-4] ୪.୦ ^୪.୧ Riss, J.; Cloyd, J.; Gates, J.; Collins, S. (Aug 2008). "Benzodiazepines in epilepsy: pharmacology and pharmacokinetics". Acta Neurol Scand. 118 (2): 69–86. doi:10.1111/j.1600-0404.2008.01004.x. PMID 18384456. Archived from the original (PDF) on 2020-04-04. Retrieved 2015-10-26.

[5] Shorter, Edward (2005). "B". A Historical Dictionary of Psychiatry. Oxford University Press. ISBN 9780190292010.

[6] "Clonazepam". International Drug Price Indicator Guide. Archived from the original on 30 October 2015. Retrieved 15 August 2015.

[7] Martino, edited by Davide; Cavanna, Andrea E. (2013). Advances in the neurochemistry and neuropharmacology of Tourette Syndrome. Burlington: Elsevier Science. p. 357. ISBN 9780124115613. In several countries, presciption and use is now severely limited due to abusive recreational use of clonazepam. {{cite book}}: |first1= has generic name (help)

[8] Fisher, Gary L. (2009). Encyclopedia of substance abuse prevention, treatment, & recovery. Los Angeles: SAGE. p. 100. ISBN 9781412950848. frequently abused

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