କିଟୋଟିଫେନ

କିଟୋଟିଫେନ
Clinical data
Trade names	Zaditor, Zaditen
Synonyms	Ketotifen fumarate
AHFS/Drugs.com	monograph
MedlinePlus	a604033
Pregnancy; category	AU: B1 ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth (tablets), topical eye drops
Legal status
Legal status	US: By mouth — withdrawn, was Rx-only; Eye drops — over-the-counter;
Pharmacokinetic data
Bioavailability	60%
Protein binding	75%
Metabolism	Hepatic
Elimination half-life	12 hours
Identifiers
	IUPAC name 4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one;
ECHA InfoCard	100.047.348
Chemical and physical data
Formula	C19H19NOS
Molar mass	୩୦୯.୪୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3c1sccc1C(\c2c(cccc2)C3)=C4/CCN(C)CC4;
	InChI InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3 ; Key:ZCVMWBYGMWKGHF-UHFFFAOYSA-N ;
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କିଟୋଟିଫେନ, ଏକ ବିକ୍ରୟ ନାମ ଜାଡିଟର, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଆଲର୍ଜିକ କଞ୍ଜକ୍ଟିଭାଇଟିସ ଏବଂ ଆଲର୍ଜିକ ନାକ ପ୍ରଦାହର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଆଖି ବୁନ୍ଦା ଭାବରେ ପ୍ରୟୋଗ କରାଯାଏ ।^[୨] ^[୧]

ପାଟିରେ ଔଷଧ ନେଲେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଦ୍‌ବେଗ, ଶୋଇବାରେ ଅସୁବିଧା ଏବଂ ବିରକ୍ତି ଭାବ ହୋଇପାରେ ।^[୨] ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା, ଯେତେବେଳେ ଆଖି ବୁନ୍ଦା ଭାବରେ ବ୍ୟବହାର କଲାବେଳେ ଆଖି ଲାଲ ଦେଖାଯାଇପାରେ, ନାକରୁ ପାଣି ପ୍ରବାହିତ ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ପ୍ରାୟ ସୁପାରିଶ କରାଯାଏ ନାହିଁ, କିନ୍ତୁ ଏହାଦ୍ୱାରା କୌଣସି କ୍ଷତି ହେବାର ପ୍ରମାଣ ନାହିଁ ।^[୨] ଏହା ଏକ ଏଚ_୧-ଆଣ୍ଟିହିଷ୍ଟାମିନ ଏବଂ ମାଷ୍ଟ ସେଲ ଷ୍ଟାବିଲାଇଜର ଔଷଧ ।^[୩]

୧୯୭୦ ମସିହାରେ କିଟୋଟିଫେନ ପେଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୭୬ରେ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୧ମିଗ୍ରା ବିଶିଷ୍ଟ ୬୦ଟି ବଟିକାର ମୂଲ୍ୟ ୮ ପାଉଣ୍ଡ ।^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୫ ମିଲି ଆଖି ବୁନ୍ଦା ବୋତଲର ମୂଲ୍ୟ ପ୍ରାୟ ୭ ଡଲାର ଅଟେ ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Zaditor- ketotifen fumarate solution". DailyMed. 13 February 2020. Archived from the original on 11 June 2021. Retrieved 4 September 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 302. ISBN 978-0857114105.
↑ ^୩.୦ ^୩.୧ "Ketotifen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 June 2021. Retrieved 1 December 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2021-07-12.
↑ "Compare Ketotifen Prices - GoodRx". GoodRx. Archived from the original on 2020-11-23. Retrieved 2021-12-01.

[PI2021-1] ୧.୦ ^୧.୧ ^୧.୨ "Zaditor- ketotifen fumarate solution". DailyMed. 13 February 2020. Archived from the original on 11 June 2021. Retrieved 4 September 2020.

[BNF81-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 302. ISBN 978-0857114105.

[AHFS2021-3] ୩.୦ ^୩.୧ "Ketotifen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 June 2021. Retrieved 1 December 2021.

[Fis2006-4] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 548. ISBN 9783527607495. Archived from the original on 2020-08-13. Retrieved 2021-07-12.

[5] "Compare Ketotifen Prices - GoodRx". GoodRx. Archived from the original on 2020-11-23. Retrieved 2021-12-01.

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Clinical data

Trade names	Zaditor,^[୧] Zaditen^[୨]
Synonyms	Ketotifen fumarate
AHFS/Drugs.com	monograph
MedlinePlus	a604033
Pregnancy category	AU: B1 US: N (Not classified yet)
Routes of administration	By mouth (tablets), topical eye drops
Legal status
Legal status	US: By mouth — withdrawn, was Rx-only; Eye drops — over-the-counter
Pharmacokinetic data
Bioavailability	60%
Protein binding	75%
Metabolism	Hepatic
Elimination half-life	12 hours
Identifiers
IUPAC name 4-(1-Methylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one
ECHA InfoCard	100.047.348
Chemical and physical data
Formula	C₁₉H₁₉NOS
Molar mass	୩୦୯.୪୩ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C3c1sccc1C(\c2c(cccc2)C3)=C4/CCN(C)CC4
InChI InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3^Y Key:ZCVMWBYGMWKGHF-UHFFFAOYSA-N^Y
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