ଓର୍ଲିଷ୍ଟାଟ

ଓର୍ଲିଷ୍ଟାଟ
Clinical data
Trade names	Xenical, Alli, others
Synonyms	Tetrahydrolipstatin
AHFS/Drugs.com	monograph
MedlinePlus	a601244
data	EU EMA: yes; US FDA: Orlistat;
Pregnancy; category	AU: B1 ; US: X (Contraindicated) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S3 (Pharmacist only) ; UK: Pharmacy medicines ; US: OTC ;
Pharmacokinetic data
Bioavailability	Negligible
Protein binding	>99%
Metabolism	In the GI tract
Elimination half-life	1 to 2 hours
Excretion	Fecal
Identifiers
	IUPAC name (S)-((S)-1-((2S,3S)-3-Hexyl-4-oxooxetan-2-yl)tridecan-2-yl) 2-formamido-4-methylpentanoate;
ECHA InfoCard	100.167.400
Chemical and physical data
Formula	C29H53NO5
Molar mass	୪୯୫.୭୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O[C@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)CCCCCCCCCCC)[C@@H](NC=O)CC(C)C;
	InChI InChI=1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1 ; Key:AHLBNYSZXLDEJQ-FWEHEUNISA-N ;
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ଓର୍ଲିଷ୍ଟାଟ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଜେନିକାଲ୍, ଏକ ପ୍ରକାର ଔଷଧ ଯାହା ମେଦବହୁଳତାର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହି ଔଷଧର ମଧ୍ୟମ ଧରଣର ପ୍ରଭାବ ରହେ ଓ ଏକ ବର୍ଷ ମଧ୍ୟରେ ପ୍ରାୟ ୨-୩ କେଜି ଓଜନ ହ୍ରାସ କରେ ।^[୩] ମେଦବହୁଳ ବ୍ୟକ୍ତିଙ୍କର ମଧୁମେହ ଟାଇପ୍-୨ ରୋଗ ଆଶଙ୍କା ହ୍ରାସ କରିଥାଏ ଓ ଏହା ଜୀବନଚର୍ଯ୍ୟା ପ୍ରଳୀରେ ପରିବର୍ତ୍ତନ ଆଣେ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତେଲିଆ ମଳ ଜାତ ହୁଏ ଓ ଅନ୍ତନଳୀ ନିୟନ୍ତ୍ରଣ ରହେ ନାହିଁ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, କେତେକ ଭିଟାମିନ୍ ଅଭାବ, ଯକୃତ ସମସ୍ୟା, ବୃକ୍‌କ ପଥର ରୋଗ ଏବଂ ପିତ୍ତାସ୍ମରୀ ରୋଗ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ସତର୍କ ରହିବାକୁ ପରାମର୍ଶ ଦିଆଯାଏ ।^[୫] ଖାଦ୍ୟରୁ ଚର୍ବିର ଅବଶୋଷଣକୁ ରୋକିବାଦ୍ୱାରା ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨] ଏହା ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ସହିତ ବ୍ୟାୟାମ କରିବାକୁ ଉପଦେଶ ଦିଆଯାଏ । ^[୬]

୧୯୯୮ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୧୯୯୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଓର୍ଲିଷ୍ଟାଟ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୬] ଏହା ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଅଷ୍ଟ୍ରେଲିଆ, ୟୁରୋପ ଏବଂ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ବିନା ପ୍ରେସକ୍ରିପସନରେ ଉପଲବ୍ଧ ।^[୭] ^[୨] ^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ୪ ସପ୍ତାହ ଚିକିତ୍ସା ପାଇଁ ପ୍ରାୟ £ ୨୫ ଖର୍ଚ୍ଚ ହୁଏ । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶି ପ୍ରାୟ ୮୦ ଡଲାର ଅଟେ ।^[୯]

ଆଧାର

↑ Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers". J Clin Pharmacol. 35 (11): 1103–8. doi:10.1002/j.1552-4604.1995.tb04034.x. PMID 8626884. S2CID 23618845.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Orlistat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 January 2021. Retrieved 9 November 2021.
↑ Padwal R, Li SK, Lau DC (2004). Padwal RS (ed.). "Long-term pharmacotherapy for obesity and overweight". Cochrane Database Syst Rev (3): CD004094. doi:10.1002/14651858.CD004094.pub2. PMC 8078201. PMID 15266516.
↑ Gillies, CL; Abrams, KR; Lambert, PC; Cooper, NJ; Sutton, AJ; Hsu, RT; Khunti, K (10 February 2007). "Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis". BMJ (Clinical Research Ed.). 334 (7588): 299. doi:10.1136/bmj.39063.689375.55. PMC 1796695. PMID 17237299.
↑ ^୫.୦ ^୫.୧ ^୫.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 100. ISBN 978-0857114105.
↑ ^୬.୦ ^୬.୧ "Xenical". Archived from the original on 15 April 2021. Retrieved 9 November 2021.
↑ "POISONS STANDARD JUNE 2017". Federal Register of Legislation. Therapeutic Goods Administration. June 2017. Archived from the original on 13 December 2020. Retrieved 18 August 2017.
↑ "Chemists to provide obesity pill". BBC News Online. 21 January 2009. Archived from the original on 23 January 2009. Retrieved 22 January 2009.
↑ "Compare Alli Prices - GoodRx". GoodRx. Retrieved 9 November 2021.

[1] Zhi J, Melia AT, Eggers H, Joly R, Patel IH (1995). "Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers". J Clin Pharmacol. 35 (11): 1103–8. doi:10.1002/j.1552-4604.1995.tb04034.x. PMID 8626884. S2CID 23618845.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Orlistat Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 5 January 2021. Retrieved 9 November 2021.

[Padwal-3] Padwal R, Li SK, Lau DC (2004). Padwal RS (ed.). "Long-term pharmacotherapy for obesity and overweight". Cochrane Database Syst Rev (3): CD004094. doi:10.1002/14651858.CD004094.pub2. PMC 8078201. PMID 15266516.

[BMJ2007-4] Gillies, CL; Abrams, KR; Lambert, PC; Cooper, NJ; Sutton, AJ; Hsu, RT; Khunti, K (10 February 2007). "Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis". BMJ (Clinical Research Ed.). 334 (7588): 299. doi:10.1136/bmj.39063.689375.55. PMC 1796695. PMID 17237299.

[BNF81-5] ୫.୦ ^୫.୧ ^୫.୨ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 100. ISBN 978-0857114105.

[EPAR2021-6] ୬.୦ ^୬.୧ "Xenical". Archived from the original on 15 April 2021. Retrieved 9 November 2021.

[7] "POISONS STANDARD JUNE 2017". Federal Register of Legislation. Therapeutic Goods Administration. June 2017. Archived from the original on 13 December 2020. Retrieved 18 August 2017.

[BBC-8] "Chemists to provide obesity pill". BBC News Online. 21 January 2009. Archived from the original on 23 January 2009. Retrieved 22 January 2009.

[9] "Compare Alli Prices - GoodRx". GoodRx. Retrieved 9 November 2021.

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