ଏପ୍ଟିନେଜୁମାବ

ଏପ୍ଟିନେଜୁମାବ
Monoclonal antibody
Type	Whole antibody
Source	Humanized
Target	CALCA, CALCB
Clinical data
Trade names	Vyepti
Synonyms	ALD403, eptinezumab-jjmr
AHFS/Drugs.com	monograph
data	US DailyMed: Eptinezumab;
Pregnancy; category	AU: B1 ; ;
Routes of; administration	Intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; CA: Schedule D ; US: ℞-only ; EU: Rx-only ;
Chemical and physical data
Formula	C6352H9838N1694O1992S46
Molar mass	୧,୪୩,୨୮୩.୨0 g·mol−1

ଏପ୍ଟିନେଜୁମାବ (ଇଂରାଜୀ ଭାଷାରେ Eptinezumab), ଭିଏପ୍ଟି ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ଏକ ଔଷଧ ଯାହା ବୟସ୍କମାନଙ୍କଠାରେ ହେଉଥିବା ଅଧକପାଳିକୁ ରୋକିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୬] ଯେଉଁମାନଙ୍କ ପ୍ରତି ମାସରେ ଅତି କମରେ ଚାରି ଥର ଅଧକପାଳି ହୁଏ, ସେମାନଙ୍କ ପାଇଁ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୫] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଧୀରେ ଧୀରେ ଦିଆଯାଏ ।^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନାକ ପ୍ରବାହ ଏବଂ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ହୋଇପାରେ ।^[୬] ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ପ୍ରମାଣ ନଥିବାବେଳେ ଏହାର ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୬] ଏହା ଏକ ମୋନୋକ୍ଲୋନାଲ ଆଣ୍ଟିବଡି ଯାହା କାଲସିଟୋନିନ୍ ଜିନ୍ ସମ୍ବନ୍ଧୀୟ ପେପ୍ଟାଇଡକୁ (CGRP) ଅବରୋଧ କରିଥାଏ ।^[୬]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୟୁରୋପରେ ଏବଂ ୨୦୨୨ରେ ବ୍ରିଟେନରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏପ୍ଟିନେଜୁମାବ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ^[୫] ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୨ ସୁଦ୍ଧା ଏହାର ଏକ ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୭୦୦ ଡଲାର ଥିଲ ।^[୮] ଏହା କ୍ଲଷ୍ଟର ମୁଣ୍ଡବିନ୍ଧାର ଚିକିତ୍ସା ନିମନ୍ତେ ଅଧ୍ୟୟନ କରାଯାଉଛି ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Vyepti". Therapeutic Goods Administration (TGA). 24 June 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
↑ "Alder BioPharmaceuticals Initiates PROMISE 2 Pivotal Trial of Eptinezumab for the Prevention of Migraine". Alder Biopharmaceuticals. November 28, 2016. Archived from the original on 9 August 2017. Retrieved 28 December 2016.
↑ "AusPAR: Eptinezumab". Therapeutic Goods Administration (TGA). 3 March 2022. Archived from the original on 24 March 2022. Retrieved 23 March 2022.
↑ "Summary Basis of Decision (SBD) for Vyepti". Health Canada. 23 October 2014. Archived from the original on 30 May 2022. Retrieved 29 May 2022.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Vyepti EPAR". European Medicines Agency (EMA). 11 November 2021. Archived from the original on 8 June 2022. Retrieved 8 June 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ ^୬.୬ "Vyepti- eptinezumab-jjmr injection". DailyMed. Archived from the original on 28 September 2021. Retrieved 27 September 2021.
↑ ^୭.୦ ^୭.୧ "Eptinezumab". SPS - Specialist Pharmacy Service. 29 June 2017. Archived from the original on 12 November 2022. Retrieved 4 November 2022.
↑ "Vyepti Prices, Coupons, Copay & Patient Assistance". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 August 2021. Retrieved 4 November 2022.

[Vyepti_APM_summary-1] ୧.୦ ^୧.୧ "Vyepti". Therapeutic Goods Administration (TGA). 24 June 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.

[2] "Alder BioPharmaceuticals Initiates PROMISE 2 Pivotal Trial of Eptinezumab for the Prevention of Migraine". Alder Biopharmaceuticals. November 28, 2016. Archived from the original on 9 August 2017. Retrieved 28 December 2016.

[3] "AusPAR: Eptinezumab". Therapeutic Goods Administration (TGA). 3 March 2022. Archived from the original on 24 March 2022. Retrieved 23 March 2022.

[4] "Summary Basis of Decision (SBD) for Vyepti". Health Canada. 23 October 2014. Archived from the original on 30 May 2022. Retrieved 29 May 2022.

[EPAR2022-5] ୫.୦ ^୫.୧ ^୫.୨ "Vyepti EPAR". European Medicines Agency (EMA). 11 November 2021. Archived from the original on 8 June 2022. Retrieved 8 June 2022. Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2022-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ ^୬.୪ ^୬.୫ ^୬.୬ "Vyepti- eptinezumab-jjmr injection". DailyMed. Archived from the original on 28 September 2021. Retrieved 27 September 2021.

[SPS2022-7] ୭.୦ ^୭.୧ "Eptinezumab". SPS - Specialist Pharmacy Service. 29 June 2017. Archived from the original on 12 November 2022. Retrieved 4 November 2022.

[8] "Vyepti Prices, Coupons, Copay & Patient Assistance". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 August 2021. Retrieved 4 November 2022.

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