ଏକ୍ସେମେସ୍ଟେନ

ଏକ୍ସେମେସ୍ଟେନ
Clinical data
Pronunciation	/ˌɛksəˈmɛˌsteɪn/; EK-sə-ME-stayn
Trade names	Aromasin
Synonyms	FCE-24304
AHFS/Drugs.com	monograph
MedlinePlus	a607006
Pregnancy; category	US: D (Evidence of risk) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Bioavailability	~60%[ଆଧାର ଲୋଡ଼ା]
Protein binding	90%
Metabolism	Liver (CYP3A4, aldo-keto reductase)
Elimination half-life	24 hours
Duration of action	4–5 days[ଆଧାର ଲୋଡ଼ା]
Excretion	Urine and feces ~ 1:1 (mainly metabolites)
Identifiers
	IUPAC name 6-Methylideneandrosta-1,4-diene-3,17-dione;
ECHA InfoCard	100.171.149
Chemical and physical data
Formula	C20H24O2
Molar mass	୨୯୬.୪୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C\1\C=C/[C@]3(C(=C/1)/C(=C)C[C@H]4[C@@H]2CCC(=O)[C@]2(CC[C@H]34)C)C;
	InChI InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1 ; Key:BFYIZQONLCFLEV-DAELLWKTSA-N ;
(verify)

ଏକ୍ସେମେସ୍ଟେନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଆରୋମାସିନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ସ୍ତନ କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ନିର୍ଦ୍ଦିଷ୍ଟ ଭାବରେ ଏହା ପ୍ରାରମ୍ଭିକ ଇଷ୍ଟ୍ରୋଜେନ ପଜିଟିଭ ରିସେପ୍ଟର ରୋଗ ବା ଆଗେଇ ଯାଇଥିବା ରୋଗ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ଯାହା ଟାମୋକ୍ସିଫେନ୍ ପ୍ରତିରୋଧକ ହୋଇପାରିଛି ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗରମ ଲାଲିମା, ଥକ୍କା, ଗଣ୍ଠି ଯନ୍ତ୍ରଣା, ଶୋଇବାରେ ଅସୁବିଧା ଏବଂ ଅଧିକ ସ୍ୱେଦ ନିର୍ଗମନ ହୋଇଥାଏ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଓଷ୍ଟିଓପୋରୋସିସ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ। ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୩] ଏହା ଏକ ଆରୋମାଟେଜ୍ ଇନହିବିଟର ଯାହା ଇଷ୍ଟ୍ରୋଜେନ ସୃଷ୍ଟିକୁ ଅବରୋଧ କରିଥାଏ ।^[୩] ^[୪]

୧୯୯୮ ମସିହାରେ ଯୁକ୍ତରାଜ୍ୟରେ ଏବଂ ୧୯୯୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ଏକ୍ସେମେସ୍ଟେନକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୫] ^[୬] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଏକ ମାସର ଖର୍ଚ୍ଚର ମୂଲ୍ୟ ପ୍ରାୟ ୨୧ ପାଉଣ୍ଡ ।^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୫୦ ଡଲାର ଅଟେ।^[୭]

ଆଧାର

↑ Exemestane Archived 2015-12-23 at the Wayback Machine. at ChEBI
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 998. ISBN 978-0857114105.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "DailyMed - EXEMESTANE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 17 December 2021.
↑ "Exemestane". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 December 2021.
↑ "Aromasin - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 13 May 2021. Retrieved 17 December 2021.
↑ "Exemestane Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 17 December 2021.
↑ "Exemestane Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 21 October 2016. Retrieved 17 December 2021.

[CHeBIID-1] Exemestane Archived 2015-12-23 at the Wayback Machine. at ChEBI

[BNF81-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 998. ISBN 978-0857114105.

[PI2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "DailyMed - EXEMESTANE tablet". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 17 December 2021.

[Liv2021-4] "Exemestane". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 6 May 2021. Retrieved 17 December 2021.

[5] "Aromasin - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 13 May 2021. Retrieved 17 December 2021.

[AHFS2021-6] "Exemestane Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 17 December 2021.

[7] "Exemestane Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 21 October 2016. Retrieved 17 December 2021.

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Clinical data


Pronunciation	/ˌɛksəˈmɛˌsteɪn/ EK-sə-ME-stayn
Trade names	Aromasin
Synonyms	FCE-24304
AHFS/Drugs.com	monograph
MedlinePlus	a607006
Pregnancy category	US: D (Evidence of risk)
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	~60%^{[ଆଧାର ଲୋଡ଼ା]}
Protein binding	90%
Metabolism	Liver (CYP3A4, aldo-keto reductase)
Elimination half-life	24 hours
Duration of action	4–5 days^{[ଆଧାର ଲୋଡ଼ା]}
Excretion	Urine and feces ~ 1:1 (mainly metabolites)
Identifiers
IUPAC name 6-Methylideneandrosta-1,4-diene-3,17-dione^[୧]
ECHA InfoCard	100.171.149
Chemical and physical data
Formula	C₂₀H₂₄O₂
Molar mass	୨୯୬.୪୧ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C\1\C=C/[C@]3(C(=C/1)/C(=C)C[C@H]4[C@@H]2CCC(=O)[C@]2(CC[C@H]34)C)C
InChI InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1^Y Key:BFYIZQONLCFLEV-DAELLWKTSA-N^Y
(verify)