ଇମିକ୍ୟୁମୋଡ

ଇମିକ୍ୟୁମୋଡ
Clinical data
Trade names	Aldara, others
Synonyms	1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
AHFS/Drugs.com	monograph
MedlinePlus	a698010
data	EU EMA: yes; US DailyMed: Imiquimod;
Pregnancy; category	AU: B1 ; US: C (Risk not ruled out) ; ;
Routes of; administration	Topical
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Elimination half-life	30 hours (topical dose), 2 hours (subcutaneous dose)
Identifiers
	IUPAC name 3-(2-Methylpropyl)-3,5,8-triazatricyclo[7.4.0.02,6]trideca-1(9),2(6),4,7,10,12-hexaen-7-amine;
ECHA InfoCard	100.131.047
Chemical and physical data
Formula	C14H16N4
Molar mass	୨୪୦.୩୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES n3c1ccccc1c2c(ncn2CC(C)C)c3N;
	InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17) ; Key:DOUYETYNHWVLEO-UHFFFAOYSA-N ;
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ଇମିକ୍ୟୁମୋଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଆଲଡାରା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଯୌନାଙ୍ଗ ଭାତୁଡ଼ି, ବ‌ହିସ୍ଥ ବାସାଲ ସେଲ କାର୍ସିନୋମା, ମୋଲୁସ୍କମ କୋଣ୍ଟାଜିଓସମ ଏବଂ ଆକ୍ଟିନିକ୍ କେରାଟୋସିସ୍ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ^[୪] ଏହା ଏକ କ୍ରିମ୍ ଭାବରେ ପ୍ରୟୋଗ କରାଯାଏ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଫୁଲା, ଲାଲ ରଙ୍ଗ, ଚର୍ମରୁ ଚୋପା ଛାଡ଼ିବା ଏବଂ ସ୍ଥାନୀୟ ଫୋଟକା ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଅଇ, ଏବଂ ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୪] ଯଦିଓ ଏହାର କାର୍ଯ୍ୟ ପ୍ରଣାଳୀ ସ୍ପଷ୍ଟ ନୁହେଁ; ଏହା କିଛି ମାତ୍ରାରେ ପ୍ରତିରକ୍ଷା ପ୍ରଣାଳୀର କିଛି ଅଂଶକୁ ସକ୍ରିୟ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୋଇଥାଏ ।^[୩]

ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ୧୯୯୭ ମସିହାରେ ଇମିକ୍ୟୁମୋଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ୧୨ ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୫୦ ପାଉଣ୍ଡ ଅଟେ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୧୬ ଡଲାର ଥିଲା ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Imiquimod topical Use During Pregnancy". Drugs.com. 29 May 2019. Archived from the original on 17 July 2020. Retrieved 14 July 2020.
↑ Drugs.com Drugs.com international listings for imiquimod Archived 2016-03-04 at the Wayback Machine. Page accessed June 14, 2015
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Imiquimod Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2016. Retrieved 19 July 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1352. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୫.୦ ^୫.୧ "Imiquimod Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 13 November 2016. Retrieved 19 July 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Imiquimod topical Use During Pregnancy". Drugs.com. 29 May 2019. Archived from the original on 17 July 2020. Retrieved 14 July 2020.

[drugnames-2] Drugs.com Drugs.com international listings for imiquimod Archived 2016-03-04 at the Wayback Machine. Page accessed June 14, 2015

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Imiquimod Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2016. Retrieved 19 July 2021.

[BNF80-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 1352. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[GX2021-5] ୫.୦ ^୫.୧ "Imiquimod Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 13 November 2016. Retrieved 19 July 2021.

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Clinical data

Trade names	Aldara, others^[୨]
Synonyms	1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
AHFS/Drugs.com	monograph
MedlinePlus	a698010
data	EU EMA: yes US DailyMed: Imiquimod
Pregnancy category	AU: B1 ^[୧] US: C (Risk not ruled out) ^[୧]
Routes of administration	Topical
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only EU: Rx-only
Pharmacokinetic data
Elimination half-life	30 hours (topical dose), 2 hours (subcutaneous dose)
Identifiers
IUPAC name 3-(2-Methylpropyl)-3,5,8-triazatricyclo[7.4.0.0^2,6]trideca-1(9),2(6),4,7,10,12-hexaen-7-amine
ECHA InfoCard	100.131.047
Chemical and physical data
Formula	C₁₄H₁₆N₄
Molar mass	୨୪୦.୩୧ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES n3c1ccccc1c2c(ncn2CC(C)C)c3N
InChI InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)^Y Key:DOUYETYNHWVLEO-UHFFFAOYSA-N^Y
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