ଆସଫୋଟେଜ ଆଲଫା

ଆସଫୋଟେଜ ଆଲଫା
Clinical data
Trade names	Strensiq
Synonyms	ALXN-1215
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Asfotase_alfa;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	Subcutaneous injection
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	46–98%
Elimination half-life	~5 days
Chemical and physical data
Formula	C7108H11008N1968O2206S56
Molar mass	୧,୬୧,୧୨୫.୧୮ g·mol−1

ଆସଫୋଟେଜ ଆଲଫା, ବିକ୍ରୟ ନାମ ଷ୍ଟ୍ରେନସିକ, ଏକ ଔଷଧ ଯାହା ଶିଶୁମାନଙ୍କଠାରେ ଆରମ୍ଭ ହେଉଥିବା ହାଇପୋଫସଫାଟାସିଆ (HPP) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ହୁଏ । ^[୩] ^[୪] ଏହା ଚର୍ମ ତଳେ ଇଞ୍ଜେକ୍ସନ୍ ଆକାରରେ ଦିଆଯାଏ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ଚର୍ମ ଲାଲ ହେବା, ଅଙ୍ଗମାନଙ୍କରେରେ ଯନ୍ତ୍ରଣା, ଜ୍ୱର, ଲାଇପୋଡିଷ୍ଟ୍ରୋଫି, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଏବଂ ଇଞ୍ଜେକ୍ସନ ସ୍ଥାନରେ ବ୍ରୁଇ ହୋଇପାରେ । ^[୪] ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଖି କିମ୍ବା ବୃକ୍ କର କାଲସିଫିକେସନ୍ ହୋଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୧] ଏହା ଏକ ତନ୍ତୁ ଅଣ-ନିର୍ଦ୍ଦିଷ୍ଟ କ୍ଷାରୀୟ ଫସଫାଟେଜ୍ (ALP) ଏବଂ ଏହା ପ୍ରଭାବିତ ବ୍ୟକ୍ତିଙ୍କ ମଧ୍ୟରେ ଏହି ଏନଜାଇମ୍ ବଦଳାଇ କାର୍ଯ୍ୟ କରିଥାଏ । ^[୩]

୨୦୧୫ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଆସଫୋଟେଜ୍ ଆଲଫା ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୮୦ମିଗ୍ରା ମାତ୍ରାର ୪ ସପ୍ତାହର ଔଷଧର ଖର୍ଚ୍ଚ ୨୦୨୧ରେ ୫୬,୫୦୦ ଡଲାର ଥିଲା । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୭୦,୨୦୦ ଡଲାର ଅଟେ । ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Asfotase alfa (Strensiq) Use During Pregnancy". Drugs.com. 15 July 2019. Archived from the original on 31 October 2020. Retrieved 10 May 2020.
↑ "Strensiq - Summary of Product Characteristics (SmPC)". (emc). 21 January 2020. Archived from the original on 14 July 2017. Retrieved 10 May 2020.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Strensiq- asfotase alfa solution". DailyMed. 7 February 2018. Archived from the original on 24 March 2021. Retrieved 10 May 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Strensiq EPAR". European Medicines Agency (EMA). Archived from the original on 29 December 2019. Retrieved 10 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1115. ISBN 978-0857114105.
↑ "Strensiq Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 May 2021. Retrieved 16 January 2022.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ ^୧.୨ "Asfotase alfa (Strensiq) Use During Pregnancy". Drugs.com. 15 July 2019. Archived from the original on 31 October 2020. Retrieved 10 May 2020.

[2] "Strensiq - Summary of Product Characteristics (SmPC)". (emc). 21 January 2020. Archived from the original on 14 July 2017. Retrieved 10 May 2020.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "Strensiq- asfotase alfa solution". DailyMed. 7 February 2018. Archived from the original on 24 March 2021. Retrieved 10 May 2020.

[EPAR2022-4] ୪.୦ ^୪.୧ ^୪.୨ "Strensiq EPAR". European Medicines Agency (EMA). Archived from the original on 29 December 2019. Retrieved 10 May 2020. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[BNF81-5] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1115. ISBN 978-0857114105.

[6] "Strensiq Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 May 2021. Retrieved 16 January 2022.

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