ଆମିସଲପ୍ରାଇଡ

ଆମିସଲପ୍ରାଇଡ
Clinical data
Trade names	Solian, Barhemsys, Socian, Deniban, others
Synonyms	APD421
AHFS/Drugs.com	monograph
data	US DailyMed: Amisulpride;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth, intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	48%
Protein binding	16%
Metabolism	Liver (minimal; most excreted unchanged)
Elimination half-life	12 hours
Excretion	Kidney (23–46%), Faecal
Identifiers
	IUPAC name 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;
ECHA InfoCard	100.068.916
Chemical and physical data
Formula	C17H27N3O4S
Molar mass	୩୬୯.୪୮ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(c1cc(c(OC)cc1N)C(=O)NCC2N(CC)CCC2)CC;
	InChI InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) ; Key:NTJOBXMMWNYJFB-UHFFFAOYSA-N ;
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ଆମିସଲପ୍ରାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସୋଲିଆନ୍, ଏକ ଔଷଧ ଯାହା ସ୍କିଜୋଫ୍ରେନିଆର ଚିକିତ୍ସା ପାଇଁ ଓ ଅସ୍ତ୍ରୋପଚାର ପରବର୍ତ୍ତୀ ଅଇ ତ‌ଥା ବାନ୍ତିର (PONV) ପ୍ରତିରୋଧ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୮] ^[୯] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଶିରାରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ । ^[୮] ^[୯]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ସ୍ତନ ଯନ୍ତ୍ରଣା, ଯୌନ ଅସୁବିଧା ଏବଂ କମ୍ ପୋଟାସିୟମ୍ ହୋଇପାରେ । ^[୮] ^[୯] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ୟୁଟି (QT) ବିସ୍ତାର, ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା ଏବଂ ଅସ୍ୱାଭାବିକ ଲିପିଡ ହୋଇପାରେ । ^[୮] ^[୯] ଗର୍ଭାବସ୍ଥାରେ ଏହାର ନିରାପତ୍ତା ଅସ୍ପଷ୍ଟ ଥିବାବେଳେ ଏହା ଅନ୍ୟ ପ୍ରାଣୀମାନଙ୍କ ବ୍ୟବହାରରେ କ୍ଷତି ଘଟାଇଛି। ^[୧୦] ଏହା ଏକ ଆଟିପିକାଲ୍ ଆଣ୍ଟିସାଇକୋଟିକ୍ ଯାହା ଡୋପାମାଇନ ଡି୨ (D2) ଏବଂ ଡି୩ (D 3) ରିସେପ୍ଟରଗୁଡିକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହେଉଥିବା ବିଶ୍ୱାସ କରାଯାଏ । ^[୮]

ଆମିସୁଲପ୍ରାଇଡ୍ ୧୯୯୨ ମସିହାରୁ ଚିକିତ୍ସା ବ୍ୟବହାରରେ ଅଛି । ^[୧୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୮] ଯୁକ୍ତରାଜ୍ୟରେ ୪୦୦ ମିଗ୍ରାର ୬୦ଟି ବଟିକାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ £ ୪୨ ଅଟେ । ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ୫ ମିଗ୍ରା ଭାଏଲର ମୂଲ୍ୟ ୪୫ ଡଲାର । ^[୧୨]

ଆଧାର

↑ "Australian Product Information – Solian (Amisulpride) Tablets And Solution". TGA eBS. Archived from the original on 31 December 2019. Retrieved 10 May 2020.
↑ ^୨.୦ ^୨.୧ "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com. 2 September 2020. Archived from the original on 28 January 2021. Retrieved 24 September 2020.
↑ "Amisulpride 100 mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 5 July 2019. Archived from the original on 26 February 2020. Retrieved 26 February 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Solian tablets and solution product information" (PDF). TGA eBusiness Services. Sanofi-Aventis Australia Pty Ltd. 27 September 2019. Archived from the original on 31 December 2019. Retrieved 26 February 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ Rosenzweig, P.; Canal, M.; Patat, A.; Bergougnan, L.; Zieleniuk, I.; Bianchetti, G. (2002). "A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers". Human Psychopharmacology. 17 (1): 1–13. doi:10.1002/hup.320. PMID 12404702. S2CID 23877366.
↑ Caccia, S (May 2000). "Biotransformation of Post-Clozapine Antipsychotics Pharmacological Implications". Clinical Pharmacokinetics. 38 (5): 393–414. doi:10.2165/00003088-200038050-00002. PMID 10843459. S2CID 68853079.
↑ Noble, S; Benfield, P (December 1999). "Amisulpride: A Review of its Clinical Potential in Dysthymia". CNS Drugs. 12 (6): 471–483. doi:10.2165/00023210-199912060-00005.
↑ ^୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 415. ISBN 978-0857114105.
↑ ^୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ "Amisulpride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.
↑ "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 14 January 2022.
↑ Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome (in ଇଂରାଜୀ). Academic Press. 27 November 2013. p. 318. ISBN 978-0-12-411561-3. Archived from the original on 14 January 2022. Retrieved 14 January 2022.
↑ "Barhemsys Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.

[1] "Australian Product Information – Solian (Amisulpride) Tablets And Solution". TGA eBS. Archived from the original on 31 December 2019. Retrieved 10 May 2020.

[Drugs.com_pregnancy-2] ୨.୦ ^୨.୧ "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com. 2 September 2020. Archived from the original on 28 January 2021. Retrieved 24 September 2020.

[Amisulpride_SmPC-3] "Amisulpride 100 mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 5 July 2019. Archived from the original on 26 February 2020. Retrieved 26 February 2020.

[SOLIAN-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Solian tablets and solution product information" (PDF). TGA eBusiness Services. Sanofi-Aventis Australia Pty Ltd. 27 September 2019. Archived from the original on 31 December 2019. Retrieved 26 February 2020.

[Rosenzweig-5] ୫.୦ ^୫.୧ ^୫.୨ Rosenzweig, P.; Canal, M.; Patat, A.; Bergougnan, L.; Zieleniuk, I.; Bianchetti, G. (2002). "A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers". Human Psychopharmacology. 17 (1): 1–13. doi:10.1002/hup.320. PMID 12404702. S2CID 23877366.

[BT-6] Caccia, S (May 2000). "Biotransformation of Post-Clozapine Antipsychotics Pharmacological Implications". Clinical Pharmacokinetics. 38 (5): 393–414. doi:10.2165/00003088-200038050-00002. PMID 10843459. S2CID 68853079.

[Dys-7] Noble, S; Benfield, P (December 1999). "Amisulpride: A Review of its Clinical Potential in Dysthymia". CNS Drugs. 12 (6): 471–483. doi:10.2165/00023210-199912060-00005.

[BNF81-8] ୮.୦ ^୮.୧ ^୮.୨ ^୮.୩ ^୮.୪ ^୮.୫ ^୮.୬ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 415. ISBN 978-0857114105.

[AHFS2022-9] ୯.୦ ^୯.୧ ^୯.୨ ^୯.୩ "Amisulpride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.

[10] "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 14 January 2022.

[11] Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome (in ଇଂରାଜୀ). Academic Press. 27 November 2013. p. 318. ISBN 978-0-12-411561-3. Archived from the original on 14 January 2022. Retrieved 14 January 2022.

[12] "Barhemsys Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 January 2022.

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