ଆମିଟ୍ରିପ୍ଟିଲିନ

ଆମିଟ୍ରିପ୍ଟିଲିନ
Clinical data
Pronunciation	/ˌæmɪˈtrɪptɪliːn/
Trade names	Amitrip, Elevil, Endep, Levate
AHFS/Drugs.com	monograph
MedlinePlus	a682388
data	US FDA: Amitriptyline;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	Oral, intramuscular
ATC code	N06AA09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	30–60% due to first pass metabolism
Protein binding	96%<
Metabolism	Liver
Elimination half-life	10 to 50 hrs
Excretion	Mostly kidney
Identifiers
	IUPAC name 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine;
CAS Number	50-48-6 ;
PubChem CID	2160;
IUPHAR/BPS	200;
DrugBank	DB00321 ;
ChemSpider	2075 ;
UNII	1806D8D52K;
KEGG	D07448 ;
ChEBI	CHEBI:2666 ;
ChEMBL	CHEMBL629 ;
ECHA InfoCard	100.000.038
Chemical and physical data
Formula	C20H23N
Molar mass	277.403 g/mol
3D model (JSmol)	Interactive image;
	SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3;
	InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3 ; Key:KRMDCWKBEZIMAB-UHFFFAOYSA-N ;
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ଆମିଟ୍ରିପ୍ଟିଲିନ, ବିକ୍ରୟ ନାମ ଏଲାଭିଲ ଏକ ଔଷଧ ଯାହା ଅନେକ ପ୍ରକାର ମାନସିକ ରୋଗରେ ଦିଆଯାଏ ।^[୨] ମୂଖ୍ୟ ଅବସାଦ ରୋଗ (major depressive disorder), ଉତ୍କଣ୍ଠା ରୋଗ (anxiety disorder), ଆଟେନସନ ଡେଫିସିଟ ହାଇପରଆକ୍ଟିଭିଟି ରୋଗ (attention deficit hyperactivity disorder) ଓ ବାଇପୋଲାର ଡିଜଅର୍ଡ଼ର ଇତ୍ୟାଦି ରୋଗରେ ଏହା ଦିଆଯାଏ ।^[୨]^[୩] ଏହା ଅଧକପାଳିର ପ୍ରତିଷେଧ, ନୁରୋପାଥିକ ଯନ୍ତ୍ରଣା ଯେପରିକି ଫାଇବ୍ରୋମ୍ୟାଲଜିଆ, ପୋଷ୍ଟଥର୍ପେଟିକ ନିଉରାଲଜିଆ ଓ ନିଦ୍ରାହୀନତାର (insomnia) ଚିକିତ୍ସା କରିବାକୁ ଦିଆଯାଏ ।^[୨]^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୨]

ଶୁଷ୍କ ପାଟି, ଦୃଷ୍ଟି ସମସ୍ୟା, ଠିଆ ନିମ୍ନ ରକ୍ତଚାପ, ନିଦ୍ରାଳୁଭାବ ଓ କୋଷ୍ଠକାଠିନ୍ୟ ଇତ୍ୟାଦି ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଏହି ଔଷଧ ଯୋଗୁ ଦେଖାଯାଏ । ସାଙ୍ଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ଅପସ୍ମାର ବାତ, ୨୫ ବର୍ଷରୁ କମ ବୟସ୍କ ଲୋକଙ୍କର ଆତ୍ମହତ୍ୟା ସଙ୍କଟ, ମୂତ୍ରରୋଧ, [ଗ୍ଲକୋମା]] ଓ ହୃତ୍‌ପିଣ୍ଡ ସମସ୍ୟା ମୂଖ୍ୟତଃ ଦେଖାଯାଏ । ଏହା ଏମଏଓ ଇନହିବିଟର ଓ ସିସାପ୍ରାଇଡ ଔଷଧ ସ‌ହିତ ଦିଆଯାଏ ନାହିଁ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ଏହି ଔଷଧ ଦେଲେ ସମସ୍ୟା ହୁଏ ।^[୫]^[୨] ସ୍ତନ୍ୟପାନ କାଳରେ ଅସୁବିଧା ହୁଏନି ।^[୬] ଟ୍ରାଇସାଇକ୍ଲିକ ଅବସାଦରୋଧୀ (ଟିସିଏ) ଶ୍ରେଣୀର ଆମିଟ୍ରିପ୍ଟିଲିନ ଏକ ଔଷଧ । ଏହାର ସଠିକ କାର୍ଯ୍ୟକଳାପ ଅସ୍ପଷ୍ଟ ଅଛି ।^[୨]

ସନ ୧୯୬୦ରେ ଆମିଟ୍ରିପ୍ଟିଲିନ ଅବିଷ୍କୃତ ହୋଇଥିଲା^[୭] ଓ ଫୁଡ ଆଣ୍ଡ ଡ୍ରଗ ଆଡମିନିସ୍ଟ୍ରେସନଦ୍ୱାରା ମଞ୍ଜୁରୀ ଦିଆଯାଇଥିଲା ।^[୮] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୯] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ।^[୨] ଏହାର ଗୋଟିଏ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୦୧ରୁ ୦.୦୪ ଆମେରିକୀୟ ଡଲାର । ^[୧୦] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଡୋଜ ପିଛା ମୂଲ୍ୟ ୦.୨୦ ଡଲାର ।^[୨]

ଆଧାର

↑ "Oxford Dictionary: Definition of amitriptyline (British & World English)". Archived from the original on 2014-07-14. Retrieved 2016-02-03.
↑ ^୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ ^୨.୧୨ "Amitriptyline Hydrochloride". The American Society of Health-System Pharmacists. Retrieved Sep 25, 2014.
↑ Leucht, C; Huhn, M; Leucht, S (December 2012). "Amitriptyline versus placebo for major depressive disorder". The Cochrane Database of Systematic Reviews. 12: CD009138. doi:10.1002/14651858.CD009138.pub2. PMID 23235671.
↑ Moore, RA; Derry, S; Aldington, D; Cole, P; Wiffen, PJ (6 July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane database of systematic reviews. 7: CD008242. PMID 26146793.
↑ "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.
↑ "Amitriptyline Levels and Effects while Breastfeeding". drugs.com. Sep 8, 2014. Retrieved 25 September 2014.
↑ Sneader, Walter (2005). Drug Discovery a History. Chichester: John Wiley & Sons. p. 414. ISBN 9780470015520.
↑ Fangmann P, Assion HJ, Juckel G, González CA, López-Muñoz F (February 2008). "Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part II: tricyclics and tetracyclics". Journal of Clinical Psychopharmacology. 28 (1): 1–4. doi:10.1097/jcp.0b013e3181627b60. PMID 18204333.{{cite journal}}: CS1 maint: multiple names: authors list (link)
↑ "WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Amitriptyline". International Drug Price Indicator Guide. Archived from the original on 30 March 2017. Retrieved 2 December 2015.

[1] "Oxford Dictionary: Definition of amitriptyline (British & World English)". Archived from the original on 2014-07-14. Retrieved 2016-02-03.

[AHFS2014-2] ୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ ^୨.୧୨ "Amitriptyline Hydrochloride". The American Society of Health-System Pharmacists. Retrieved Sep 25, 2014.

[3] Leucht, C; Huhn, M; Leucht, S (December 2012). "Amitriptyline versus placebo for major depressive disorder". The Cochrane Database of Systematic Reviews. 12: CD009138. doi:10.1002/14651858.CD009138.pub2. PMID 23235671.

[Coch2015-4] Moore, RA; Derry, S; Aldington, D; Cole, P; Wiffen, PJ (6 July 2015). "Amitriptyline for neuropathic pain in adults". The Cochrane database of systematic reviews. 7: CD008242. PMID 26146793.

[5] "Prescribing medicines in pregnancy database". Australian Government. 3 March 2014. Retrieved 22 April 2014.

[6] "Amitriptyline Levels and Effects while Breastfeeding". drugs.com. Sep 8, 2014. Retrieved 25 September 2014.

[7] Sneader, Walter (2005). Drug Discovery a History. Chichester: John Wiley & Sons. p. 414. ISBN 9780470015520.

[8] Fangmann P, Assion HJ, Juckel G, González CA, López-Muñoz F (February 2008). "Half a century of antidepressant drugs: on the clinical introduction of monoamine oxidase inhibitors, tricyclics, and tetracyclics. Part II: tricyclics and tetracyclics". Journal of Clinical Psychopharmacology. 28 (1): 1–4. doi:10.1097/jcp.0b013e3181627b60. PMID 18204333.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[9] "WHO Model List of Essential Medicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[10] "Amitriptyline". International Drug Price Indicator Guide. Archived from the original on 30 March 2017. Retrieved 2 December 2015.

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Clinical data


Pronunciation	/ˌæmɪˈtrɪptɪliːn/^[୧]
Trade names	Amitrip, Elevil, Endep, Levate
AHFS/Drugs.com	monograph
MedlinePlus	a682388
data	US FDA: Amitriptyline
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	Oral, intramuscular
ATC code	N06AA09 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	30–60% due to first pass metabolism
Protein binding	96%<^[୨]
Metabolism	Liver^[୨]
Elimination half-life	10 to 50 hrs^[୨]
Excretion	Mostly kidney^[୨]
Identifiers
IUPAC name 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine
CAS Number	50-48-6^Y
PubChem CID	2160
IUPHAR/BPS	200
DrugBank	DB00321^Y
ChemSpider	2075^Y
UNII	1806D8D52K
KEGG	D07448^Y
ChEBI	CHEBI:2666^Y
ChEMBL	CHEMBL629^Y
ECHA InfoCard	100.000.038
Chemical and physical data
Formula	C₂₀H₂₃N
Molar mass	277.403 g/mol
3D model (JSmol)	Interactive image
SMILES c3cc2c(/C(c1c(cccc1)CC2)=C\CCN(C)C)cc3
InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3^Y Key:KRMDCWKBEZIMAB-UHFFFAOYSA-N^Y
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